Reflectance confocal microscopy features of uncommon histopathological variants of cutaneous melanoma

In-vivo reflectance confocal microscopy (RCM) is a non-invasive diagnostic tool representing an adds-on to clinical and dermoscopic exam to enhance the diagnosis of melanoma.1 Several diagnostic algorithm have been validated for the diagnosis of the most frequent melanoma subtypes.1 However, melanoma encompasses a wide range of distinct histological variants, often mimicking other benign and malignant skin lesions.2 We herein describe RCM pattern of 6 uncommon variants of melanoma along with a literature review. We retrospectively searched our database from January 2012 to September 2019, for histopathologically confirmed cases of uncommon variants of cutaneous melanoma defined as those different from the four primary common subtypes: superficial spreading, nodular, lentigo maligna and acral lentiginous melanoma.2.