Respiratory responses to chemical stimulation of the parabrachial nuclear complex in the rabbit

The respiratory role of the parabrachial nuclear complex (PNC) was investigated in alpha-chloralose-urethane anesthetized, vagotomized, paralysed and artificially ventilated rabbits by means of unilateral microinjections (10-20 nl) of 20 mM dl-homocysteic acid. Chemical stimulation elicited three main types of site-specific respiratory effects: excitatory, apneustic and inhibitory responses. The results suggest that the PNC plays a complex role in the control of breathing.

[1]  K. Shirato,et al.  Role of the parabrachial nucleus in ventilatory responses of awake rats. , 1995, The Journal of physiology.

[2]  J. Remmers,et al.  Effects of lesions in the parabrachial nucleus on the mechanisms for central and reflex termination of inspiration in the cat. , 1976, Acta physiologica Scandinavica.

[3]  K. Takayama,et al.  Respiratory responses to microinjection of excitatory amino acid agonists in ventrolateral regions of the lateral parabrachial nucleus in the cat , 1993, Brain Research.

[4]  F. Bertrand,et al.  Respiratory synchronizing function of nucleus parabrachialis medialis: pneumotaxic mechanisms. , 1971, Journal of neurophysiology.

[5]  T Lumsden,et al.  Observations on the respiratory centres in the cat , 1923, The Journal of physiology.

[6]  A. Goodchild,et al.  A method for evoking physiological responses by stimulation of cell bodies, but not axons of passage, within localized regions of the central nervous system , 1982, Journal of Neuroscience Methods.

[7]  H. Herbert,et al.  The Kölliker-Fuse nucleus mediates the trigeminally induced apnoea in the rat. , 1996, Neuroreport.

[8]  C. Saper,et al.  Topographic organization of respiratory responses to glutamate microstimulation of the parabrachial nucleus in the rat , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[9]  M. I. Cohen.  Switching of the respiratory phases and evoked phrenic responses produced by rostral pontine electrical stimulation , 1971, The Journal of physiology.

[10]  D. Mutolo,et al.  Depressant effects on inspiratory and expiratory activity produced by chemical activation of Bötzinger complex neurons in the rabbit , 1997, Brain Research.

[11]  D. Speck,et al.  Role of N-methyl-D-aspartate receptors in the pontine pneumotaxic mechanism in the cat. , 1994, Journal of applied physiology.

[12]  K. Takayama,et al.  Circulatory and respiratory responses to glutamate stimulation of the lateral parabrachial nucleus of the cat. , 1991, Journal of the autonomic nervous system.

[13]  J. Champagnat,et al.  Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters. , 1995, Physiological reviews.

[14]  K. Spyer,et al.  Cardiovascular and respiratory effects of stimulation of cell bodies of the parabrachial nuclei in the anaesthetized rat. , 1994, The Journal of physiology.

[15]  R. L. Holmes.  Growth of the Nervous System , 1969 .

[16]  O. Hermanson,et al.  Subnuclear localization of FOS‐like immunoreactivity in the rat parabrachial nucleus after nociceptive stimulation , 1996, The Journal of comparative neurology.