Assembly factors monitor sequential hemylation of cytochrome b to regulate mitochondrial translation

Assembly of the two heme b cofactors into the respiratory chain complex III subunit cytochrome b occurs in a step-by-step process that is monitored by assembly factors and regulates additional cytochrome b synthesis through a feedback loop.

[1]  M. Huynen,et al.  Mutations in the UQCC1-Interacting Protein, UQCC2, Cause Human Complex III Deficiency Associated with Perturbed Cytochrome b Protein Expression , 2013, PLoS genetics.

[2]  F. Fontanesi.  Mechanisms of mitochondrial translational regulation , 2013, IUBMB life.

[3]  F. Fontanesi,et al.  A heme-sensing mechanism in the translational regulation of mitochondrial cytochrome c oxidase biogenesis. , 2012, Cell metabolism.

[4]  T. Fox.  Mitochondrial Protein Synthesis, Import, and Assembly , 2012, Genetics.

[5]  M. Ott,et al.  The Cbp3–Cbp6 complex coordinates cytochrome b synthesis with bc1 complex assembly in yeast mitochondria , 2012, The Journal of cell biology.

[6]  D. Winge,et al.  Structure, function, and assembly of heme centers in mitochondrial respiratory complexes. , 2012, Biochimica et biophysica acta.

[7]  S. Jakobs,et al.  Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex. , 2012, Cell metabolism.

[8]  D. Winge,et al.  Biogenesis of the cytochrome bc(1) complex and role of assembly factors. , 2012, Biochimica et biophysica acta.

[9]  A. Imhof,et al.  Cbp3–Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly , 2011, The Journal of cell biology.

[10]  B. Guiard,et al.  c-Type Cytochrome Assembly in Saccharomyces cerevisiae: A Key Residue for Apocytochrome c1/Lyase Interaction , 2010, Genetics.

[11]  JohnB . Taylor,et al.  Cytochrome c Biogenesis: Mechanisms for Covalent Modifications and Trafficking of Heme and for Heme-Iron Redox Control , 2009, Microbiology and Molecular Biology Reviews.

[12]  R. Lill.  Function and biogenesis of iron–sulphur proteins , 2009, Nature.

[13]  A. Reichert,et al.  Mrpl36 is important for generation of assembly competent proteins during mitochondrial translation. , 2009, Molecular biology of the cell.

[14]  D. Schneider,et al.  Multiple step assembly of the transmembrane cytochrome b6. , 2008, Journal of molecular biology.

[15]  S. Duvezin-Caubet,et al.  A Yeast Model of the Neurogenic Ataxia Retinitis Pigmentosa (NARP) T8993G Mutation in the Mitochondrial ATP Synthase-6 Gene* , 2007, Journal of Biological Chemistry.

[16]  S. Merchant,et al.  Cyc2p, a Membrane-bound Flavoprotein Involved in the Maturation of Mitochondrial c-Type Cytochromes* , 2005, Journal of Biological Chemistry.

[17]  P. Dutton,et al.  Fixing the Q cycle. , 2005, Trends in biochemical sciences.

[18]  G. Brasseur,et al.  Human Disease-related Mutations in Cytochrome b Studied in Yeast* , 2004, Journal of Biological Chemistry.

[19]  A. Crofts,et al.  The cytochrome bc1 complex: function in the context of structure. , 2004, Annual review of physiology.

[20]  S. Merchant,et al.  Overlapping Specificities of the Mitochondrial Cytochrome c and c1 Heme Lyases* , 2003, Journal of Biological Chemistry.

[21]  S. Meshnick,et al.  Recapitulation in Saccharomyces cerevisiae of Cytochrome b Mutations Conferring Resistance to Atovaquone in Pneumocystis jiroveci , 2003, Antimicrobial Agents and Chemotherapy.

[22]  E. Hegg,et al.  Identification of novel hemes generated by heme A synthase: evidence for two successive monooxygenase reactions. , 2002, Biochemistry.

[23]  W. Neupert,et al.  Oxa1p acts as a general membrane insertion machinery for proteins encoded by mitochondrial DNA , 2001, The EMBO journal.

[24]  B. Meunier.  Site-directed mutations in the mitochondrially encoded subunits I and III of yeast cytochrome oxidase. , 2001, The Biochemical journal.

[25]  R A Stuart,et al.  The Cytochrome bc 1 and Cytochromec Oxidase Complexes Associate to Form a Single Supracomplex in Yeast Mitochondria* , 2000, The Journal of Biological Chemistry.

[26]  J Koepke,et al.  Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment. , 2000, Structure.

[27]  S. Merchant,et al.  Molecular Genetic Identification of a Pathway for Heme Binding to Cytochrome b 6 * , 1997, The Journal of Biological Chemistry.

[28]  A. Zollner,et al.  Heme Binding to a Conserved Cys-Pro-Val Motif Is Crucial for the Catalytic Function of Mitochondrial Heme Lyases* , 1996, The Journal of Biological Chemistry.

[29]  T. Fox,et al.  Expression of a recoded nuclear gene inserted into yeast mitochondrial DNA is limited by mRNA-specific translational activation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[30]  K. Morand,et al.  Novel prenylated hemes as cofactors of cytochrome oxidases. Archaea have modified hemes A and O. , 1994, The Journal of biological chemistry.

[31]  A. Colson,et al.  Genetic screening in Saccharomyces cerevisiae for large numbers of mitochondrial point mutations which affect structure and function of catalytic subunits of cytochrome-c oxidase. , 1993, European journal of biochemistry.

[32]  A. Crofts,et al.  Assignment of the histidine axial ligands to the cytochrome bH and cytochrome bL components of the bc1 complex from Rhodobacter sphaeroides by site-directed mutagenesis. , 1991, Biochemistry.

[33]  S. Beale,et al.  Separate physiological roles and subcellular compartments for two tetrapyrrole biosynthetic pathways in Euglena gracilis. , 1983, The Journal of biological chemistry.

[34]  B. Trumpower,et al.  Purification of a reconstitutively active iron-sulfur protein (oxidation factor) from succinate . cytochrome c reductase complex of bovine heart mitochondria. , 1979, The Journal of biological chemistry.

[35]  G. Macino,et al.  Assembly of the mitochondrial membrane system , 1979, Molecular and General Genetics MGG.

[36]  F. Foury,et al.  Assembly of the mitochondrial membrane system XIX , 1976, Molecular and General Genetics MGG.

[37]  G. Fink,et al.  A mutant of Saccharomyces cerevisiae defective for nuclear fusion. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[38]  A. Tzagoloff,et al.  Assembly of the mitochondrial membrane system. Characterization of nuclear mutants of Saccharomyces cerevisiae with defects in mitochondrial ATPase and respiratory enzymes. , 1975, Journal of Biological Chemistry.

[39]  P. Mitchell.  Protonmotive redox mechanism of the cytochrome b‐c 1 complex in the respiratory chain: Protonmotive ubiquinone cycle , 1975, FEBS letters.

[40]  Thomas D. Fox,et al.  Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation , 2010, Nature Reviews Molecular Cell Biology.

[41]  T. Fox,et al.  Directed alteration of Saccharomyces cerevisiae mitochondrial DNA by biolistic transformation and homologous recombination. , 2007, Methods in molecular biology.

[42]  P. Rangel,et al.  Haem O and a putative cytochrome bo in a mutant of Bacillus cereus impaired in the synthesis of haem A , 1997, Archives of Microbiology.