Diagnosis Error: Carcinoma or Primary Breast Lymphoma? A Case Report and Literature Review

Introduction: Breast involvement by non-Hodgkin lymphoma is particularly rare in women. We describe the case of a patient with a rapidly growing, nodule in the right breast. On ultrasonography, the nodule was suspicious for breast carcinoma. Case presentation: A breast biopsy from a 73-year-old Moroccan women answered invasive ductal carcinoma grade 3 from Elston and Ellis. Patey was performed. Microscopic examination showed lymphoid proliferation confirmed on immunohistochemical analysis. Our patient was treated with chemotherapy. Conclusions: The rarity of breast lymphomas, and the problems related to the diagnosis and therapeutic choices with these tumors require molecular techniques in association with classical histological diagnosis.

[1]  J. Simpson,et al.  Non‐Hodgkin Lymphoma of the Breast , 2012 .

[2]  P. Angunawela,et al.  Primary breast lymphoma: a rare entity. , 2011, Journal of radiology case reports.

[3]  R. Bociek,et al.  Primary diffuse large B-cell lymphoma of the breast: prognostic factors and outcomes of a study by the International Extranodal Lymphoma Study Group. , 2008, Annals of oncology : official journal of the European Society for Medical Oncology.

[4]  R. Mirimanoff,et al.  Primary breast lymphoma: Patient profile, outcome and prognostic factors. A multicentre Rare Cancer Network study , 2008, BMC Cancer.

[5]  C. Lyou,et al.  Mammographic and sonographic findings of primary breast lymphoma. , 2007, Clinical imaging.

[6]  W. Jennings,et al.  Primary Breast Lymphoma: The Role of Mastectomy and the Importance of Lymph Node Status , 2007, Annals of surgery.

[7]  J. Lamovec.  Malignant Lymphoma of the Breast , 2002 .

[8]  Juan F. García,et al.  Cutaneous Presentation of Follicular Lymphomas , 2001, Modern Pathology.

[9]  S. G. Trevisan,et al.  Primary breast lymphoma originating in a benign intramammary lymph node. , 2001, AJR. American journal of roentgenology.

[10]  J. Mattson,et al.  Lymphoma of the breast. A clinicopathologic study of primary and secondary cases. , 1999, Archives of pathology & laboratory medicine.

[11]  R. Kim,et al.  Primary lymphoma of the breast: breast mass as an initial symptom. , 1999, American journal of clinical oncology.

[12]  J. Cox,et al.  Localized primary non-Hodgkin lymphoma of the breast. , 1998, American journal of clinical oncology.

[13]  R. Fisher,et al.  Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate- and high-grade non-Hodgkin's lymphoma. , 1998, The New England journal of medicine.

[14]  S. Singletary,et al.  Surgical Management of Primary Lymphoma of the Breast , 1991, Annals of surgery.

[15]  P. Carbone,et al.  Lymphoma of the Breast , 1981, Annals of surgery.