Global methods approach in deciphering the role of TFF2 proteins in organism

Tijekom posljednjih petnaestak godina za istraživanje uloge razliciti h proteina i mehanizama nastanka bolesti primjenjuju se sistemski pristupi i analize kojima se istovremeno prate globalne promjene razine ekspresije velikog broja gena i/ili proteina. Imajuci na umu složene interakcije na razini stanica i cinjenicu kako je vecina bolesti multi faktorijalnog podrijetla, takav sistemski pristup najbolji je nacin stjecanja uvida u funkciju nekog proteina i/ili mehanizme nastanka bolesti . Proteini “Trefoil Factor Family” ili proteini TFF (TFF1, TFF2, TFF3) otkriveni su prije vise od 25 godina, te je ubrzo postalo jasno kako je njihova uloga u organizmu iznimno kompleksna. Tek je sistemski pristup istraživanju analize uloge proteina TFF2 razjasnio njegovu ulogu u organizmu pokazujuci vezu s imunoloskim sustavom.

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