Abstract Resilience of the built environment and communities to natural and man-made hazards is consolidating worldwide as a key requirement in the field of urban planning and building design, and there is an increasing awareness that Sustainable Development Goals and priorities of the Sendai Framework cannot be achieved without a comprehensive approach able to promote the effective implementation of DRR and CCA measures within regeneration processes at various scales. In this sense, an “all-hazards” approach, addressing multiple risk conditions (including Natech and cascading effects) and integrating DRR and CCA design strategies, show a highly cost-effective potential, maximizing the effect of complementary measures and optimizing mitigation/adaptation design techniques within a multi-scale (building/neighbourhood/city) resilience perspective, delivering at the same time socio-economic benefits linked to the improvement of urban spaces’ liveability and environmental quality. Vulnerability and impact assessment represent an essential component of a simulation-based methodology aimed at increasing the potential for use of scientific results by decision-makers, through multi-hazard and dynamic impact scenarios combined with cost-benefit and multi-criteria analyses to assess the effectiveness of alternative options. The paper presents the methodological approach developed at PLINIVS Study Centre and the experimental applications implemented within recent EU and National projects, such as H2020-ESPREssO and SIMMCITIES_NA.
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