NEMA NU 2-2001 performance testing of a Philips Gemini GXL PET/CT scanner

Post installation acceptance testing is vital to demonstrate that the equipment meets the vendor’s specification and is suitable for clinical studies. The test procedures described in the NEMA NU 2-2001 document form the basis of vendor performance specifications of PET scanners and hence are also appropriate for acceptance testing. Initial installation performance tests of the Philips Gemini GXL PET/CT scanner installed at Liverpool Hospital revealed that the peak noise equivalent count rate (NECR) measurement of 57.5 kcps was substantially lower than the specification of 70 kcps and the scatter fraction of 38.5% was 10% higher than the specification of ≤35%. These performance parameters potentially impact on clinical image quality and hence the deviations were considered unacceptable. The performance issues were addressed by the vendor through a hardware upgrade and optimisation of the energy window by increasing the lower discriminator value from 408.8 to 434.4 keV. Several repeat performance measurements taken from post-optimisation demonstrated improvement in peak NECR to 67 kcps with delayed window randoms subtraction “on” and 72 kcps with delayed window randoms subtraction “off”. Scatter fraction taken from post upgrade and optimisation improved to an average of 33%, which is well within specification of <35%. All other performance tests (resolution, sensitivity, accuracy of corrections) were within specifications both prior and post-optimisation changes. This experience demonstrates the importance of equipment acceptance testing prior to clinical use so that deficiencies in performance can be addressed before the equipment is placed in clinical service.

[1]  Dan J Kadrmas,et al.  LOR-OSEM: statistical PET reconstruction from raw line-of-response histograms , 2004, Physics in medicine and biology.

[2]  J. Karp,et al.  Performance of Philips Gemini TF PET/CT scanner with special consideration for its time-of-flight imaging capabilities. , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[3]  Val J Lowe,et al.  NEMA NU 2-2001 performance measurements of an LYSO-based PET/CT system in 2D and 3D acquisition modes. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[4]  Scatter fraction: measurement and correction , 2004, European Journal of Nuclear Medicine.

[5]  M N Maisey,et al.  Optimization of noise-equivalent count rates in 3D PET. , 1996, Physics in medicine and biology.

[6]  T. Lewellen,et al.  Evaluation of low energy threshold settings for PVI PET systems , 1998, 1998 IEEE Nuclear Science Symposium Conference Record. 1998 IEEE Nuclear Science Symposium and Medical Imaging Conference (Cat. No.98CH36255).

[7]  M. Partridge,et al.  Performance Evaluation of the Philips “Gemini” PET/CT System , 2006, IEEE Transactions on Nuclear Science.

[8]  S R Meikle,et al.  A convolution-subtraction scatter correction method for 3D PET. , 1994, Physics in medicine and biology.

[9]  Roberta Matheoud,et al.  Performance characteristics obtained for a new 3-dimensional lutetium oxyorthosilicate-based whole-body PET/CT scanner with the National Electrical Manufacturers Association NU 2-2001 standard. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[10]  D. Mankoff,et al.  Continuous-slice PENN-PET: a positron tomograph with volume imaging capability. , 1990, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[11]  A A Lammertsma,et al.  Characterization of a single LSO crystal layer high resolution research tomograph. , 2003, Physics in medicine and biology.

[12]  Suleman Surti,et al.  Imaging characteristics of a 3-dimensional GSO whole-body PET camera. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[13]  Thomas Beyer,et al.  PET/CT scanners: a hardware approach to image fusion. , 2003, Seminars in nuclear medicine.

[14]  G. Antoch,et al.  Can PET/CT replace separate diagnostic CT for cancer imaging? Optimizing CT protocols for imaging cancers of the chest and abdomen. , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[15]  D. Townsend,et al.  Experience with scintillators for PET: towards the fifth generation of PET scanners , 2004 .

[16]  O. Mawlawi,et al.  Performance characteristics of a newly developed PET/CT scanner using NEMA standards in 2D and 3D modes. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[17]  S.D. Wollenweber,et al.  Calculation of noise-equivalent image quality , 2003, 2003 IEEE Nuclear Science Symposium. Conference Record (IEEE Cat. No.03CH37515).

[18]  C. Meltzer,et al.  PET/CT: form and function. , 2007, Radiology.

[19]  E. Hoffman,et al.  Measuring PET scanner sensitivity: relating countrates to image signal-to-noise ratios using noise equivalents counts , 1990 .

[20]  Tim Mulnix,et al.  PET performance measurements for an LSO-based combined PET/CT scanner using the National Electrical Manufacturers Association NU 2-2001 standard. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[21]  Michael E Casey,et al.  PET performance measurements using the NEMA NU 2-2001 standard. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[22]  R. Leahy,et al.  Model-based normalization for iterative 3D PET image reconstruction , 2002 .

[23]  Valentino Bettinardi,et al.  Performance evaluation of the new whole-body PET/CT scanner: Discovery ST , 2004, European Journal of Nuclear Medicine and Molecular Imaging.

[24]  J. Debatin,et al.  Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology. , 2003, JAMA.

[25]  M. Partridge,et al.  Performance evaluation of the Philips 'Gemini' PET/CT System , 2004, IEEE Symposium Conference Record Nuclear Science 2004..

[26]  Joel S. Karp,et al.  Implementation of a single scatter simulation algorithm for 3D PET: application to emission and transmission scanning , 2002, 2002 IEEE Nuclear Science Symposium Conference Record.

[27]  Keishi Kitamura,et al.  Performance characteristics of a new 3-dimensional continuous-emission and spiral-transmission high-sensitivity and high-resolution PET camera evaluated with the NEMA NU 2-2001 standard. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.