RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways.

[1]  S. Sprang,et al.  Ric-8A Catalyzes Guanine Nucleotide Exchange on Gαi1 Bound to the GPR/GoLoco Exchange Inhibitor AGS3* , 2008, Journal of Biological Chemistry.

[2]  J. Kehrl,et al.  Localization of Giα proteins in the centrosomes and at the midbody: implication for their role in cell division , 2007, The Journal of cell biology.

[3]  Z. Goldsmith,et al.  G Protein regulation of MAPK networks , 2007, Oncogene.

[4]  E. Reddy,et al.  Scaffold proteins of MAP-kinase modules , 2007, Oncogene.

[5]  W. Snider,et al.  Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor‐mediated differentiation , 2007, The EMBO journal.

[6]  J. Hepler,et al.  Selective interactions between Giα1 and Giα3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization , 2007 .

[7]  D. Siderovski,et al.  The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells. , 2006, Cellular signalling.

[8]  M. Linder,et al.  Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A. , 2006, The Biochemical journal.

[9]  S. Lanier,et al.  Accessory proteins for G proteins: partners in signaling. , 2006, Annual review of pharmacology and toxicology.

[10]  M. Gotta,et al.  Heterotrimeric G proteins and regulation of size asymmetry during cell division. , 2005, Current opinion in cell biology.

[11]  R. Petralia,et al.  mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression , 2005, Nature Cell Biology.

[12]  A. Gilman,et al.  Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Galphai-GDP complexes. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[13]  S. Bowman,et al.  Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins , 2005, Nature Cell Biology.

[14]  David P. Siderovski,et al.  Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins , 2005, Nature Cell Biology.

[15]  L. Kinch,et al.  New Roles for Gα and RGS Proteins: Communication Continues despite Pulling Sisters Apart , 2005, Current Biology.

[16]  J. Ule,et al.  Common Molecular Pathways Mediate Long-Term Potentiation of Synaptic Excitation and Slow Synaptic Inhibition , 2005, Cell.

[17]  M. Cismowski,et al.  AGS proteins: receptor-independent activators of G-protein signaling. , 2005, Trends in pharmacological sciences.

[18]  Christina Kiel,et al.  Recognizing and defining true Ras binding domains I: biochemical analysis. , 2005, Journal of molecular biology.

[19]  Joost Schymkowitz,et al.  Recognizing and defining true Ras binding domains II: in silico prediction based on homology modelling and energy calculations. , 2005, Journal of molecular biology.

[20]  P. Chidiac,et al.  Novel activity of RGS14 on Goalpha and Gialpha nucleotide binding and hydrolysis distinct from its RGS domain and GDI activity. , 2005, Biochemistry.

[21]  T. Pawson,et al.  Behavioral / Systems / Cognitive Hippocampal Synaptic Modulation by the Phosphotyrosine Adapter Protein ShcC / N-Shc via Interaction with the NMDA Receptor , 2005 .

[22]  Dong-Uk Kim,et al.  RGS14 Is a Centrosomal and Nuclear Cytoplasmic Shuttling Protein That Traffics to Promyelocytic Leukemia Nuclear Bodies Following Heat Shock* , 2005, Journal of Biological Chemistry.

[23]  I. Macara,et al.  Mammalian Pins Is a Conformational Switch that Links NuMA to Heterotrimeric G Proteins , 2004, Cell.

[24]  J. Knoblich,et al.  Heterotrimeric G Proteins New Tricks for an Old Dog , 2004, Cell.

[25]  M. Linder,et al.  The RGS14 GoLoco Domain Discriminates among Gαi Isoforms* , 2004, Journal of Biological Chemistry.

[26]  J. Penninger,et al.  RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. , 2004, Developmental cell.

[27]  J. de Gunzburg,et al.  The RGS (regulator of G-protein signalling) and GoLoco domains of RGS14 co-operate to regulate Gi-mediated signalling. , 2004, The Biochemical journal.

[28]  A. Yuryev,et al.  Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. , 2003, Genomics.

[29]  J. Hepler,et al.  Phosphorylation of RGS14 by protein kinase a potentiates its activity toward Gαi , 2003 .

[30]  J. Hepler,et al.  Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling , 2002, Pharmacological Reviews.

[31]  R. Fisher,et al.  RGS12TS-S Localizes at Nuclear Matrix-Associated Subnuclear Structures and Represses Transcription: Structural Requirements for Subnuclear Targeting and Transcriptional Repression , 2002, Molecular and Cellular Biology.

[32]  J. Sweatt,et al.  Molecular psychology: roles for the ERK MAP kinase cascade in memory. , 2002, Annual review of pharmacology and toxicology.

[33]  E. Goldman,et al.  RGS14 is a bifunctional regulator of Gαi/o activity that exists in multiple populations in brain , 2001, Journal of neurochemistry.

[34]  Randall J. Kimple,et al.  RGS12 and RGS14 GoLoco Motifs Are GαiInteraction Sites with Guanine Nucleotide Dissociation Inhibitor Activity* , 2001, The Journal of Biological Chemistry.

[35]  X. F. Zhang,et al.  Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. , 2001, Recent progress in hormone research.

[36]  R. Fisher,et al.  Novel Alternative Splicing and Nuclear Localization of HumanRGS12 Gene Products* , 2000, The Journal of Biological Chemistry.

[37]  T. Kozasa,et al.  RGS14, a GTPase-Activating Protein for Giα, Attenuates Giα- and G13α-Mediated Signaling Pathways , 2000 .

[38]  N. Spassky,et al.  RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. , 2000, The Biochemical journal.

[39]  M. Farquhar,et al.  The regulator of G protein signaling family. , 2000, Annual review of pharmacology and toxicology.

[40]  E M Ross,et al.  GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. , 2000, Annual review of biochemistry.

[41]  J. Gutkind The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades* , 1998, The Journal of Biological Chemistry.

[42]  B. Snow,et al.  Molecular cloning and expression analysis of rat Rgs12 and Rgs14. , 1997, Biochemical and biophysical research communications.

[43]  Gudrun Horn,et al.  Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor , 1996, The Journal of Biological Chemistry.

[44]  Jonathan A. Cooper,et al.  A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function. , 1994, Proceedings of the National Academy of Sciences of the United States of America.