RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways.
暂无分享,去创建一个
[1] S. Sprang,et al. Ric-8A Catalyzes Guanine Nucleotide Exchange on Gαi1 Bound to the GPR/GoLoco Exchange Inhibitor AGS3* , 2008, Journal of Biological Chemistry.
[2] J. Kehrl,et al. Localization of Giα proteins in the centrosomes and at the midbody: implication for their role in cell division , 2007, The Journal of cell biology.
[3] Z. Goldsmith,et al. G Protein regulation of MAPK networks , 2007, Oncogene.
[4] E. Reddy,et al. Scaffold proteins of MAP-kinase modules , 2007, Oncogene.
[5] W. Snider,et al. Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor‐mediated differentiation , 2007, The EMBO journal.
[6] J. Hepler,et al. Selective interactions between Giα1 and Giα3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization , 2007 .
[7] D. Siderovski,et al. The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells. , 2006, Cellular signalling.
[8] M. Linder,et al. Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A. , 2006, The Biochemical journal.
[9] S. Lanier,et al. Accessory proteins for G proteins: partners in signaling. , 2006, Annual review of pharmacology and toxicology.
[10] M. Gotta,et al. Heterotrimeric G proteins and regulation of size asymmetry during cell division. , 2005, Current opinion in cell biology.
[11] R. Petralia,et al. mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression , 2005, Nature Cell Biology.
[12] A. Gilman,et al. Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Galphai-GDP complexes. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[13] S. Bowman,et al. Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins , 2005, Nature Cell Biology.
[14] David P. Siderovski,et al. Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins , 2005, Nature Cell Biology.
[15] L. Kinch,et al. New Roles for Gα and RGS Proteins: Communication Continues despite Pulling Sisters Apart , 2005, Current Biology.
[16] J. Ule,et al. Common Molecular Pathways Mediate Long-Term Potentiation of Synaptic Excitation and Slow Synaptic Inhibition , 2005, Cell.
[17] M. Cismowski,et al. AGS proteins: receptor-independent activators of G-protein signaling. , 2005, Trends in pharmacological sciences.
[18] Christina Kiel,et al. Recognizing and defining true Ras binding domains I: biochemical analysis. , 2005, Journal of molecular biology.
[19] Joost Schymkowitz,et al. Recognizing and defining true Ras binding domains II: in silico prediction based on homology modelling and energy calculations. , 2005, Journal of molecular biology.
[20] P. Chidiac,et al. Novel activity of RGS14 on Goalpha and Gialpha nucleotide binding and hydrolysis distinct from its RGS domain and GDI activity. , 2005, Biochemistry.
[21] T. Pawson,et al. Behavioral / Systems / Cognitive Hippocampal Synaptic Modulation by the Phosphotyrosine Adapter Protein ShcC / N-Shc via Interaction with the NMDA Receptor , 2005 .
[22] Dong-Uk Kim,et al. RGS14 Is a Centrosomal and Nuclear Cytoplasmic Shuttling Protein That Traffics to Promyelocytic Leukemia Nuclear Bodies Following Heat Shock* , 2005, Journal of Biological Chemistry.
[23] I. Macara,et al. Mammalian Pins Is a Conformational Switch that Links NuMA to Heterotrimeric G Proteins , 2004, Cell.
[24] J. Knoblich,et al. Heterotrimeric G Proteins New Tricks for an Old Dog , 2004, Cell.
[25] M. Linder,et al. The RGS14 GoLoco Domain Discriminates among Gαi Isoforms* , 2004, Journal of Biological Chemistry.
[26] J. Penninger,et al. RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. , 2004, Developmental cell.
[27] J. de Gunzburg,et al. The RGS (regulator of G-protein signalling) and GoLoco domains of RGS14 co-operate to regulate Gi-mediated signalling. , 2004, The Biochemical journal.
[28] A. Yuryev,et al. Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. , 2003, Genomics.
[29] J. Hepler,et al. Phosphorylation of RGS14 by protein kinase a potentiates its activity toward Gαi , 2003 .
[30] J. Hepler,et al. Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling , 2002, Pharmacological Reviews.
[31] R. Fisher,et al. RGS12TS-S Localizes at Nuclear Matrix-Associated Subnuclear Structures and Represses Transcription: Structural Requirements for Subnuclear Targeting and Transcriptional Repression , 2002, Molecular and Cellular Biology.
[32] J. Sweatt,et al. Molecular psychology: roles for the ERK MAP kinase cascade in memory. , 2002, Annual review of pharmacology and toxicology.
[33] E. Goldman,et al. RGS14 is a bifunctional regulator of Gαi/o activity that exists in multiple populations in brain , 2001, Journal of neurochemistry.
[34] Randall J. Kimple,et al. RGS12 and RGS14 GoLoco Motifs Are GαiInteraction Sites with Guanine Nucleotide Dissociation Inhibitor Activity* , 2001, The Journal of Biological Chemistry.
[35] X. F. Zhang,et al. Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. , 2001, Recent progress in hormone research.
[36] R. Fisher,et al. Novel Alternative Splicing and Nuclear Localization of HumanRGS12 Gene Products* , 2000, The Journal of Biological Chemistry.
[37] T. Kozasa,et al. RGS14, a GTPase-Activating Protein for Giα, Attenuates Giα- and G13α-Mediated Signaling Pathways , 2000 .
[38] N. Spassky,et al. RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. , 2000, The Biochemical journal.
[39] M. Farquhar,et al. The regulator of G protein signaling family. , 2000, Annual review of pharmacology and toxicology.
[40] E M Ross,et al. GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. , 2000, Annual review of biochemistry.
[41] J. Gutkind. The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades* , 1998, The Journal of Biological Chemistry.
[42] B. Snow,et al. Molecular cloning and expression analysis of rat Rgs12 and Rgs14. , 1997, Biochemical and biophysical research communications.
[43] Gudrun Horn,et al. Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor , 1996, The Journal of Biological Chemistry.
[44] Jonathan A. Cooper,et al. A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function. , 1994, Proceedings of the National Academy of Sciences of the United States of America.