The antibody specificity of human IgE can be determined by incubating the relevant, native, crossed immunoprecipitates with serum and subsequently visualizing the reaction by adding radiolabelled anti-IgE and performing autoradiography [715]. The method is called crossed radioimmunoelectrophoresis (CRIE) and has been used mainly for detection of patients’ IgE response to individual allergenic molecules ‘allergoprints’ and foridentification ofallergens in complex allergenic mixtures through performance of ‘allergograms’. The aim of this work is to review the current use of CRIE, with emphasis on its performance.