Interlevel Experiments and Multilevel Mechanisms in the Neuroscience of Memory

The dominant neuroscientific theory of spatial memory is, like many theories in neuroscience, a multilevel description of a mechanism. The theory links the activities of molecules, cells, brain regions, and whole organisms into an integrated sketch of an explanation for the ability of organisms to navigate novel environments. Here I develop a taxonomy of interlevel experimental strategies for integrating the levels in such multilevel mechanisms. These experimental strategies include activation strategies, interference strategies, and additive strategies. These strategies are mutually reinforcing, providing a kind of interlevel and intratheoretic robustness that has not previously been recognized.

[1]  K. Svoboda,et al.  Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity. , 1999, Science.

[2]  Hugh Lehman.  Functional Explanation in Biology , 1965, Philosophy of Science.

[3]  C. Craver.  Role Functions, Mechanisms, and Hierarchy , 2001, Philosophy of Science.

[4]  K. I. Blum,et al.  Impaired Hippocampal Representation of Space in CA1-Specific NMDAR1 Knockout Mice , 1996, Cell.

[5]  David S. Touretzky,et al.  The Role of the Hippocampus in Solving the Morris Water Maze , 1998, Neural Computation.

[6]  U. Frey,et al.  Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation , 1998, Trends in Neurosciences.

[7]  F S Mayo-Osborne.  "Remembrance of things past". E.W. Mayo. 2. , 1989, Journal of the Massachusetts Dental Society.

[8]  L. Squire,et al.  Neuroanatomy of memory. , 1993, Annual review of neuroscience.

[9]  Clark Glymour,et al.  On the Methods of Cognitive Neuropsychology , 1994, The British Journal for the Philosophy of Science.

[10]  J. O'Keefe,et al.  The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. , 1971, Brain research.

[11]  D. O. Hebb,et al.  The organization of behavior , 1988 .

[12]  Michael V. Wedin,et al.  Human Nature and Natural Knowledge , 1985 .

[13]  Jeffrey Bub.  Testing Models of Cognition Through the Analysis of Brain-Damaged Performance , 1994, The British Journal for the Philosophy of Science.

[14]  Lindley Darden,et al.  Discovering mechanisms in neurobiology: The case of spatial memory , 2001 .

[15]  W. Wimsatt.  Forms of Aggregativity , 1986 .

[16]  Ernest Sosa,et al.  Supervenience and Mind: Selected Philosophical Essays , 1993 .

[17]  S. Tonegawa,et al.  The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory , 1996, Cell.

[18]  Robert S. Stufflebeam,et al.  PET: Exploring the Myth and the Method , 1997, Philosophy of Science.

[19]  E. Capaldi,et al.  The organization of behavior. , 1992, Journal of applied behavior analysis.

[20]  David J. Anderson,et al.  Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain , 1996, Cell.

[21]  M.K.D. Schouten,et al.  Reduction, elimination, and levels: The case of the LTP-learning link , 1999 .

[22]  Daniel L. Schacter,et al.  Remembrance of Things Past , 1999, Science.

[23]  B L McNaughton,et al.  Dynamics of the hippocampal ensemble code for space. , 1993, Science.

[24]  H. Rheinberger.  Toward a History of Epistemic Things: Synthesizing Proteins in the Test Tube , 1997 .

[25]  R. Malinow,et al.  Silencing the Controversy in LTP? , 1998, Neuron.

[26]  Lindley Darden,et al.  Strategies in the interfield discovery of the mechanism of protein synthesis , 2002 .

[27]  T. Bliss,et al.  Neurobiology: Young receptors make smart mice , 1999, Nature.

[28]  A. Müller.  The Cement of the Universe: A Study of Causation , 1977 .

[29]  James Woodward,et al.  Explanation and Invariance in the Special Sciences , 2000, The British Journal for the Philosophy of Science.

[30]  E. Kandel,et al.  Mice Expressing Activated CaMKII Lack Low Frequency LTP and Do Not Form Stable Place Cells in the CA1 Region of the Hippocampus , 1996, Cell.

[31]  I. Hacking,et al.  Representing and Intervening. , 1986 .

[32]  L. Darden.  Theory Change in Science: Strategies from Mendelian Genetics , 1991 .

[33]  P. Machamer,et al.  Thinking about Mechanisms , 2000, Philosophy of Science.

[34]  E. Shimizu,et al.  Genetic enhancement of learning and memory in mice , 1999, Nature.

[35]  F. Engert,et al.  Dendritic spine changes associated with hippocampal long-term synaptic plasticity , 1999, Nature.

[36]  Ernest Nagel,et al.  Functional Explanations in Biology , 1977 .