Factor VIIa inhibitors: target hopping in the serine protease family using X-ray structure determination.
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S. Kadono | T. Shiraishi | Yoshiaki Watanabe | K. Hattori | Akihisa Sakamoto | Hitoshi Iikura | Y. Ono | Haruhiko Sato | T. Kozono | T. Kitazawa | K. Yoshihashi | K. Esaki | M. Haramura | M. Ohta | T. Koga | H. Kodama | T. Esaki
[1] A. Turpie. Oral, Direct Factor Xa Inhibitors in Development for the Prevention and Treatment of Thromboembolic Diseases , 2007, Arteriosclerosis, thrombosis, and vascular biology.
[2] A. Spyropoulos. Investigational treatments of venous thromboembolism , 2007, Expert opinion on investigational drugs.
[3] J. Weitz,et al. Beyond heparin and warfarin: the new generation of anticoagulants , 2007, Expert opinion on investigational drugs.
[4] S. Schellong,et al. New anticoagulants , 2007, Hämostaseologie.
[5] M. Okada,et al. Design, synthesis and biological activity of selective and orally available TF/FVIIa complex inhibitors containing non-amidine P1 ligands. , 2007, Bioorganic & medicinal chemistry.
[6] E. Gjerstad,et al. Potent 4-amino-5-azaindole factor VIIa inhibitors. , 2006, Bioorganic & medicinal chemistry letters.
[7] D. Banner,et al. Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity. , 2006, Bioorganic & medicinal chemistry.
[8] B. Katz,et al. Novel 5-azaindole factor VIIa inhibitors. , 2006, Bioorganic & medicinal chemistry letters.
[9] B. Katz,et al. Discovery of novel heterocyclic factor VIIa inhibitors. , 2006, Bioorganic & medicinal chemistry letters.
[10] J. Janc,et al. Factor VIIa inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model. , 2006, Bioorganic & medicinal chemistry letters.
[11] L. Weber,et al. Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors. , 2005, Bioorganic & medicinal chemistry letters.
[12] G. Poda,et al. Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa. , 2005, Bioorganic & medicinal chemistry letters.
[13] T. Kayahara,et al. Optimization of a coagulation factor VIIa inhibitor found in factor Xa inhibitor library. , 2005, Bioorganic & medicinal chemistry.
[14] G. Halliday,et al. Tamarind Inhibits Solar-Simulated Ultraviolet Radiation-Induced Suppression of Recall Responses in Humans , 2005 .
[15] S. Kadono,et al. Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: high selectivity against thrombin by introducing two charged groups in P2 and P4. , 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.
[16] Tsukasa Suzuki,et al. Novel interactions of large P3 moiety and small P4 moiety in the binding of the peptide mimetic factor VIIa inhibitor. , 2005, Biochemical and biophysical research communications.
[17] S. Kadono,et al. Crystal structure of human factor VIIa/tissue factor in complex with peptide mimetic inhibitor. , 2004, Biochemical and biophysical research communications.
[18] T. Girard,et al. Pharmacological Intervention at Disparate Sites in the Coagulation Cascade: Comparison of Anti-thrombotic Efficacy vs. Bleeding Propensity in a Rat Model of Acute Arterial Thrombosis , 2002, Journal of Thrombosis and Thrombolysis.
[19] M. S. South,et al. Pharmacological Interruption of Acute Thrombus Formation with Minimal Hemorrhagic Complications by a Small Molecule Tissue Factor/Factor VIIa Inhibitor: Comparison to Factor Xa and Thrombin Inhibition in a Nonhuman Primate Thrombosis Model , 2003, Journal of Pharmacology and Experimental Therapeutics.
[20] D. Kirchhofer,et al. Inhibition of Arterial Thrombosis by a Soluble Tissue Factor Mutant and Active Site-blocked Factors IXa and Xa in the Guinea Pig , 2001, Thrombosis and Haemostasis.
[21] V. Fuster,et al. Redefining medical treatment in the management of unstable angina. , 2011, The American journal of medicine.
[22] J. Willerson,et al. Thromboresistance of balloon-injured porcine carotid arteries after local gene transfer of human tissue factor pathway inhibitor. , 2000, Circulation.
[23] K. Harlos,et al. Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla). , 1999, Journal of structural biology.
[24] A M Brzozowski,et al. Structure of human factor VIIa and its implications for the triggering of blood coagulation. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[25] B Honig,et al. On the calculation of binding free energies using continuum methods: Application to MHC class I protein‐peptide interactions , 1997, Protein science : a publication of the Protein Society.
[26] R. Kelley,et al. A soluble tissue factor mutant is a selective anticoagulant and antithrombotic agent. , 1997, Blood.
[27] David W. Banner,et al. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor , 1996, Nature.
[28] B. Tidor,et al. Do salt bridges stabilize proteins? A continuum electrostatic analysis , 1994, Protein science : a publication of the Protein Society.
[29] S. Katakura,et al. A novel factor Xa inhibitor: structure-activity relationships and selectivity between factor Xa and thrombin. , 1993, Biochemical and biophysical research communications.
[30] D. Turk,et al. The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships , 1992, Protein science : a publication of the Protein Society.
[31] K Fujikawa,et al. The coagulation cascade: initiation, maintenance, and regulation. , 1991, Biochemistry.
[32] R. Huber,et al. The refined 1.9 A crystal structure of human alpha‐thrombin: interaction with D‐Phe‐Pro‐Arg chloromethylketone and significance of the Tyr‐Pro‐Pro‐Trp insertion segment. , 1989, The EMBO journal.
[33] R. Kikumoto,et al. Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-l-arginyl)]-2-piperidinecarboxylic acid. , 1984, Biochemistry.