Tumour genotypes account for survival differences in right‐ and left‐sided colon cancers

We sought to identify genetic differences between right‐ and left‐sided colon cancers and using these differences explain lower survival in right‐sided cancers.

[1]  R. Labianca,et al.  Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. , 2020, The Lancet. Oncology.

[2]  Xiaowei Yan,et al.  Discovering the molecular differences between right- and left-sided colon cancer using machine learning methods , 2020, BMC Cancer.

[3]  J. Ross,et al.  Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer. , 2019, Annals of oncology : official journal of the European Society for Medical Oncology.

[4]  S. Furney,et al.  Meta‐analysis of the molecular associations of mucinous colorectal cancer , 2019, The British journal of surgery.

[5]  M. Ebert,et al.  Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab. , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  Julia M. Rohrer,et al.  Thinking Clearly About Correlations and Causation: Graphical Causal Models for Observational Data , 2017 .

[7]  A. Lin,et al.  FOXAI: a phase II trial evaluating the efficacy and safety of hepatic arterial infusion of oxaliplatin plus fluorouracil/leucovorin for advanced hepatocellular carcinoma , 2017, Gut.

[8]  S. Kopetz,et al.  Right Versus Left Colon Cancer Biology: Integrating the Consensus Molecular Subtypes. , 2017, Journal of the National Comprehensive Cancer Network : JNCCN.

[9]  S. Kopetz,et al.  Current companion diagnostics in advanced colorectal cancer; getting a bigger and better piece of the pie. , 2017, Journal of gastrointestinal oncology.

[10]  S. Barni,et al.  Prognostic Survival Associated With Left-Sided vs Right-Sided Colon Cancer: A Systematic Review and Meta-analysis , 2017, JAMA oncology.

[11]  Maciej Liskiewicz,et al.  Robust causal inference using Directed Acyclic Graphs: the R package , 2018 .

[12]  Y. Kitagawa,et al.  The Worse Prognosis of Right-Sided Compared with Left-Sided Colon Cancers: a Systematic Review and Meta-analysis , 2016, Journal of Gastrointestinal Surgery.

[13]  Robert Tibshirani,et al.  Post‐selection inference for ℓ1 ‐penalized likelihood models , 2016, The Canadian journal of statistics = Revue canadienne de statistique.

[14]  William M. Grady,et al.  Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers. , 2015, Gastroenterology.

[15]  D. Tu,et al.  Location of colon cancer (right-sided versus left-sided) as a prognostic factor and a predictor of benefit from cetuximab in NCIC CO.17. , 2015, European journal of cancer.

[16]  X. M. Li,et al.  Identification of commonly dysregulated genes in colorectal cancer by integrating analysis of RNA-Seq data and qRT-PCR validation , 2015, Cancer Gene Therapy.

[17]  Claudia Maggi,et al.  Predictive role of BRAF mutations in patients with advanced colorectal cancer receiving cetuximab and panitumumab: a meta-analysis. , 2015, European journal of cancer.

[18]  F T Bosman,et al.  Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features. , 2014, Annals of oncology : official journal of the European Society for Medical Oncology.

[19]  J. Gonzalez-Bosquet,et al.  MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress , 2014, Molecular Cancer.

[20]  Dennis L. Sun,et al.  Exact post-selection inference, with application to the lasso , 2013, 1311.6238.

[21]  Max Kuhn,et al.  Applied Predictive Modeling , 2013 .

[22]  Steven J. M. Jones,et al.  Comprehensive molecular characterization of human colon and rectal cancer , 2012, Nature.

[23]  Irmtraud M. Meyer,et al.  The clonal and mutational evolution spectrum of primary triple-negative breast cancers , 2012, Nature.

[24]  Matej Horvat,et al.  Microsatellite instability in colorectal cancer , 2011, Radiology and oncology.

[25]  Trevor Hastie,et al.  Regularization Paths for Cox's Proportional Hazards Model via Coordinate Descent. , 2011, Journal of statistical software.

[26]  Jin-Rong Zhou,et al.  Smad4 inactivation promotes malignancy and drug resistance of colon cancer. , 2011, Cancer research.

[27]  A. Bhattacharyya,et al.  Carcinogenicity of deoxycholate, a secondary bile acid , 2011, Archives of Toxicology.

[28]  Yong-jig Cho,et al.  Antimetastatic role of Smad4 signaling in colorectal cancer. , 2010, Gastroenterology.

[29]  C. Rancourt,et al.  MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells , 2010, Molecular Cancer.

[30]  H. Lippert,et al.  Comparison of 17,641 Patients With Right- and Left-Sided Colon Cancer: Differences in Epidemiology, Perioperative Course, Histology, and Survival , 2010, Diseases of the colon and rectum.

[31]  J. Zell,et al.  Tumor Subsite Location Within the Colon Is Prognostic for Survival After Colon Cancer Diagnosis , 2009, Diseases of the colon and rectum.

[32]  K. Truninger,et al.  Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters , 2009, Oncogene.

[33]  B. Yin,et al.  Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene , 2002, International journal of cancer.

[34]  J. Habbema,et al.  Prognostic modelling with logistic regression analysis: a comparison of selection and estimation methods in small data sets. , 2000, Statistics in medicine.

[35]  J. Herman,et al.  CpG island methylator phenotype in colorectal cancer. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[36]  J. Bufill,et al.  Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. , 1990, Annals of internal medicine.

[37]  Nedyalko Petrov,et al.  Classifiers Accuracy Improvement Based on Missing Data Imputation , 2018, J. Artif. Intell. Soft Comput. Res..

[38]  A. Dreher.  Modeling Survival Data Extending The Cox Model , 2016 .

[39]  Steven A. Roberts,et al.  Mutational heterogeneity in cancer and the search for new cancer genes , 2014 .

[40]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[41]  C. T. Pappas,et al.  The Nebulin family: an actin support group. , 2011, Trends in cell biology.

[42]  C. Compton,et al.  AJCC Cancer Staging Manual , 2002, Springer New York.