Effect of Transdermal Fentanyl Patch Combined with Enhanced Recovery after Surgery on the Curative Effect and Analgesic Effect of Liver Cancer

Its goal was to see how a transdermal fentanyl patch combined with accelerated recovery after surgery (ERAS) affected the treatment efficacy and analgesic effect of liver cancer, as well as to help patients with liver cancer choose the right analgesic treatment and nursing mode. 150 patients with liver cancer were divided into group A (transdermal fentanyl patch), group B (ERAS), and group C (transdermal fentanyl patch combined with ERAS). Patients in the three groups were compared in terms of pain, survival, psychological status, adverse responses, postoperative recovery, and patient satisfaction. The results showed that under different treatment and nursing methods, the number of patients with mild cancer pain in the three groups was increased, especially the number of patients with mild cancer pain in group C (P < 0.05). Besides, the quality of life score of patients in each group was decreased. Patients who received the combination analgesia had a significantly higher quality of life than those who received simply a transdermal fentanyl patch or ERAS (P < 0.05). The scores of both the Hamilton anxiety scale (HAMA) and Hamilton depression rating scale (HAMD) of patients with the combined analgesia were decreased signally (P < 0.05). There were few patients with combined analgesia who had adverse reactions (P < 0.05). After surgery, the time of the first anal exhaust, first defecation, and first ambulation in group C were shorter than those in the other two groups (P < 0.05). To summarize, combining the two techniques aided in the recovery of gastrointestinal function as well as the physical recovery of patients following surgery. Furthermore, combining the two approaches produced a clear analgesic impact, which could improve patients' quality of life while also having a favorable clinical adoption effect.

[1]  Jian Wang,et al.  Application of Accelerated Rehabilitation Surgery in Gastrointestinal Surgery , 2021, Computational and Mathematical Methods in Medicine.

[2]  M. Govendir,et al.  Pharmacokinetic Profile of Fentanyl in the Koala (Phascolarctos cinereus) after Intravenous Administration, and Absorption via a Transdermal Patch , 2021, Animals : an open access journal from MDPI.

[3]  Luyun He,et al.  Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling , 2021, Molecular Cancer.

[4]  J. González‐Gallego,et al.  Impact of aging on primary liver cancer: epidemiology, pathogenesis and therapeutics , 2021, Aging.

[5]  R. Leblanc,et al.  The use of nanotechnology to combat liver cancer: Progress and perspectives. , 2021, Biochimica et biophysica acta. Reviews on cancer.

[6]  J. Calderaro,et al.  Rare variants of primary liver cancer: Fibrolamellar, combined, and sarcomatoid hepatocellular carcinomas. , 2021, European journal of medical genetics.

[7]  N. Yang,et al.  Clinical effect of application of nursing concept of rehabilitation surgery for improvement of quality of postoperative recovery in orthopedics , 2021, Journal of Orthopaedic Surgery and Research.

[8]  L. Zender,et al.  The immunological and metabolic landscape in primary and metastatic liver cancer , 2021, Nature Reviews Cancer.

[9]  Huan-fang Fan,et al.  Acupuncture Combined with Three-Step Analgesic Drug Therapy for Treatment of Cancer Pain: A Systematic Review and Meta-Analysis of Randomised Clinical Trials , 2021, Evidence-based complementary and alternative medicine : eCAM.

[10]  M. Juhascik,et al.  Fentanyl, Acetylfentanyl, and Carfentanil in Impaired Driving Cases: A Review of 270 Cases. , 2021, Journal of analytical toxicology.

[11]  F. Romano,et al.  Rethinking the Barcelona clinic liver cancer guidelines: Intermediate stage and Child-Pugh B patients are suitable for surgery? , 2021, World journal of gastroenterology.

[12]  M. Nurunnabi,et al.  Recent advances in bionanomaterials for liver cancer diagnosis and treatment. , 2021, Biomaterials science.

[13]  Duo Qian,et al.  A systematic review and meta-analysis of the effects of general anesthesia combined with continuous paravertebral block in breast cancer surgery and postoperative analgesia. , 2021, Gland surgery.

[14]  Hifzur R Siddique,et al.  Pluripotency inducing Yamanaka factors: role in stemness and chemoresistance of liver cancer , 2021, Expert review of anticancer therapy.

[15]  T. Greten,et al.  MDSCs in liver cancer: A critical tumor-promoting player and a potential therapeutic target. , 2021, Cellular immunology.

[16]  E. Halboub,et al.  Association of Periodontitis and tooth loss with liver cancer: A systematic review. , 2021, Critical reviews in oncology/hematology.

[17]  O. Levy,et al.  Accelerated Rehabilitation following Reverse Total Shoulder Arthroplasty. , 2021, Journal of shoulder and elbow surgery.

[18]  Z. Lu,et al.  Integrative analysis of long extracellular RNAs reveals a detection panel of noncoding RNAs for liver cancer , 2021, Theranostics.

[19]  X. Wang,et al.  Understanding tumor cell heterogeneity and its implication for immunotherapy in liver cancer by single cell analysis. , 2020, Journal of hepatology.

[20]  F. Tacke,et al.  Dendritic Cell and T Cell Crosstalk in Liver Fibrogenesis and Hepatocarcinogenesis: Implications for Prevention and Therapy of Liver Cancer , 2020, International journal of molecular sciences.

[21]  A. Dahan,et al.  Reduced postoperative pain using Nociception Level-guided fentanyl dosing during sevoflurane anaesthesia: a randomised controlled trial , 2020, British journal of anaesthesia.

[22]  Meng Li,et al.  Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance , 2020, Cellular and molecular gastroenterology and hepatology.

[23]  D. Arens,et al.  Transdermal Fentanyl Uptake at Two Different Patch Locations in Swiss White Alpine Sheep , 2020, Animals : an open access journal from MDPI.

[24]  Ziqi Ye,et al.  Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial , 2020, Drug design, development and therapy.

[25]  F. Pottoo,et al.  Insights into nanotherapeutic strategies as an impending approach for liver cancer treatment. , 2020, Current topics in medicinal chemistry.

[26]  Rong Zhou,et al.  Effects of Oxycodone Combined With Flurbiprofen Axetil on Postoperative Analgesia and Immune Function in Patients Undergoing Radical Resection of Colorectal Cancer , 2020, Clinical pharmacology in drug development.

[27]  Zhang Cheng,et al.  New insights on sorafenib resistance in liver cancer with correlation of individualized therapy. , 2020, Biochimica et biophysica acta. Reviews on cancer.

[28]  Z. Ahmad,et al.  Cervical epidural analgesia combined with general anesthesia for head and neck cancer surgery: A randomized study , 2020, Journal of anaesthesiology, clinical pharmacology.

[29]  Toufic R. Jildeh,et al.  Comparison of Tendon Lengthening With Traditional Versus Accelerated Rehabilitation After Achilles Tendon Repair: A Prospective Randomized Controlled Trial , 2020, The American journal of sports medicine.

[30]  Yu-Chen Wang,et al.  [Application of accelerated rehabilitation program for the treatment of intertrochanteric fracture of femur in the elderly]. , 2019, Zhongguo gu shang = China journal of orthopaedics and traumatology.

[31]  Jae Jun Lee,et al.  A randomized controlled trial , 2018 .

[32]  S. Yoon,et al.  Neuropathic cancer pain: prevalence, pathophysiology, and management , 2018, The Korean journal of internal medicine.

[33]  M. Carmont,et al.  Development of an accelerated functional rehabilitation protocol following minimal invasive Achilles tendon repair , 2015, Knee Surgery, Sports Traumatology, Arthroscopy.