论文信息 - Screening of Some Marine Organism Extracts for cAMP Phosphodiesterase Inhibition, Cytotoxicity, and Antiviral Activity against HSV-1

Screening of Some Marine Organism Extracts for cAMP Phosphodiesterase Inhibition, Cytotoxicity, and Antiviral Activity against HSV-1

Methanol and hot water extracts of 71 samples of 56 kinds of marine products were subjected to inhibitory test for cyclicAMP phosphodiesterase (cAMP PDE), cytotoxic and anti-viral screening tests. Among them, 7 extracts of marine products showed a significant inhibition for cAMP PDE and 5 extracts showed a significant cytotoxicity against KB cells at concentrations under 20 µg/ml. Eight extracts of marine products showed higher therapeutic indexes against herpes simplex virus type 1 (HSV-1).

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