A study of N250 event-related brain potential during face and non-face detection tasks.

Face perception relies on activation of a complex set of different neural modules. In this study, we assessed the stimulus selectivity of the occipitotemporal N250 ERP component and the possible link between its neural substrates and modules underlying preceding (N170/VPP) and following (P400) category selective ERPs. We recorded N250 during face and leaf detection tasks while we varied stimulus visibility from trial to trial by using a backward masking paradigm. Our results revealed that N250, but not the other tested potentials, was exclusively sensitive to the visibility of faces even when the non-face stimuli served as the task target. We also found a correlation between evoked N170 and N250, in response to face stimuli and to a lesser extent in response to other non-face objects, irrespective of the subjects' task. Besides N250, P400 also showed a strong correlation with N170, but here, the amount of correlation was not affected by stimulus category. Interestingly, despite N250 and N400 correlation with N170, we did not find any correlation between N250 and P400, suggesting that modules underlying these ERP components belong to two different face-processing pathways. We suggest that N250 is initiated by N170 and indexes processes exclusively responsible for encoding faces.

[1]  R A McCarthy,et al.  Prosopagnosia and structural encoding of faces: evidence from event-related potentials. , 1999, Neuroreport.

[2]  Alex Martin,et al.  Properties and mechanisms of perceptual priming , 1998, Current Opinion in Neurobiology.

[3]  R. Henson,et al.  Electrophysiological and haemodynamic correlates of face perception, recognition and priming. , 2003, Cerebral cortex.

[4]  M. Eimer.  The face‐specific N170 component reflects late stages in the structural encoding of faces , 2000, Neuroreport.

[5]  James W. Tanaka,et al.  Activation of Preexisting and Acquired Face Representations: The N250 Event-related Potential as an Index of Face Familiarity , 2006, Journal of Cognitive Neuroscience.

[6]  D. Jeffreys.  Evoked Potential Studies of Face and Object Processing , 1996 .

[7]  M. Tarr,et al.  The N170 occipito‐temporal component is delayed and enhanced to inverted faces but not to inverted objects: an electrophysiological account of face‐specific processes in the human brain , 2000, Neuroreport.

[8]  Aina Puce,et al.  Category-sensitive excitatory and inhibitory processes in human extrastriate cortex. , 2002, Journal of neurophysiology.

[9]  A. Burton,et al.  N250r: a face-selective brain response to stimulus repetitions , 2004, Neuroreport.

[10]  Rob Jenkins,et al.  Capacity limits for face processing , 2005, Cognition.

[11]  M. Doherty,et al.  The control of attention to faces. , 2007, Journal of vision.

[12]  O. Grüsser,et al.  Category-related components in visual evoked potentials: photographs of faces, persons, flowers and tools as stimuli , 2004, Experimental Brain Research.

[13]  J. Tanaka.  The entry point of face recognition: evidence for face expertise. , 2001, Journal of experimental psychology. General.

[14]  Lynn C. Robertson,et al.  Processing the Trees and the Forest during Initial Stages of Face Perception: Electrophysiological Evidence , 2006, Journal of Cognitive Neuroscience.

[15]  Stefan R Schweinberger,et al.  Face repetition effects in direct and indirect tasks: an event-related brain potentials study. , 2004, Brain research. Cognitive brain research.

[16]  Markus Kiefer,et al.  Masked and unmasked electrophysiological repetition effects of famous faces , 2006, Brain Research.

[17]  Anna S. Law,et al.  Attention capture by faces , 2008, Cognition.

[18]  A. Young,et al.  Understanding face recognition. , 1986, British journal of psychology.

[19]  J. Tanaka,et al.  An electrophysiological comparison of visual categorization and recognition memory , 2002, Cognitive, affective & behavioral neuroscience.

[20]  D. Maurer,et al.  The many faces of configural processing , 2002, Trends in Cognitive Sciences.

[21]  Werner Sommer,et al.  Repetition priming and associative priming of face recognition: Evidence from event-related potentials. , 1995 .

[22]  Margot J. Taylor,et al.  Inversion and Contrast Polarity Reversal Affect both Encoding and Recognition Processes of Unfamiliar Faces: A Repetition Study Using ERPs , 2002, NeuroImage.

[23]  J. Tanaka,et al.  Features and their configuration in face recognition , 1997, Memory & cognition.

[24]  Markus F. Neumann,et al.  N250r and N400 ERP correlates of immediate famous face repetition are independent of perceptual load , 2008, Brain Research.

[25]  Jon Driver,et al.  Ignoring famous faces: Category-specific dilution of distractor interference , 2003, Perception & psychophysics.

[26]  S. Carey,et al.  Why faces are and are not special: an effect of expertise. , 1986, Journal of experimental psychology. General.

[27]  D. Jeffreys,et al.  The influence of stimulus orientation on the vertex positive scalp potential evoked by faces , 1993, Experimental Brain Research.

[28]  Margot J. Taylor,et al.  N170 or N1? Spatiotemporal differences between object and face processing using ERPs. , 2004, Cerebral cortex.

[29]  B. Rossion,et al.  Right N170 modulation in a face discrimination task: an account for categorical perception of familiar faces. , 2000, Psychophysiology.

[30]  R. Desimone,et al.  Neural mechanisms for visual memory and their role in attention. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[31]  L. Deouell,et al.  STRUCTURAL ENCODING AND IDENTIFICATION IN FACE PROCESSING: ERP EVIDENCE FOR SEPARATE MECHANISMS , 2000, Cognitive neuropsychology.

[32]  P. Perona,et al.  Face identification in the near-absence of spatial attention , 2010 .

[33]  J. Theeuwes,et al.  Faces capture attention: Evidence from inhibition of return , 2006 .

[34]  D. Jeffreys,et al.  The vertex-positive scalp potential evoked by faces and by objects , 2004, Experimental Brain Research.

[35]  Marcia Grabowecky,et al.  Electrophysiological Correlates of Recollecting Faces of Known and Unknown Individuals , 2000, NeuroImage.

[36]  T. Allison,et al.  Electrophysiological Studies of Face Perception in Humans , 1996, Journal of Cognitive Neuroscience.

[37]  T. Allison,et al.  Electrophysiological studies of human face perception. I: Potentials generated in occipitotemporal cortex by face and non-face stimuli. , 1999, Cerebral cortex.

[38]  J. Haxby,et al.  The distributed human neural system for face perception , 2000, Trends in Cognitive Sciences.

[39]  Karl J. Friston.  Functional and effective connectivity in neuroimaging: A synthesis , 1994 .

[40]  Gyula Kovács,et al.  Inverted Faces , 2003, Perception.

[41]  L. Deouell,et al.  Cognitive Neuroscience: Selective visual streaming in face recognition: evidence from developmental prosopagnosia , 1999 .

[42]  C. Joyce,et al.  The face-sensitive N170 and VPP components manifest the same brain processes: The effect of reference electrode site , 2005, Clinical Neurophysiology.

[43]  D Jeffreys.  Evoked potential studies of face-processing in man , 1991 .

[44]  V. Bruce,et al.  The Quarterly Journal of Experimental Psychology Section A: Human Experimental Psychology When Inverted Faces Are Recognized: the Role of Configural Information in Face Recognition , 2022 .

[45]  K. Bötzel,et al.  Scalp topography and analysis of intracranial sources of face-evoked potentials , 2004, Experimental Brain Research.

[46]  A. Burton,et al.  Event-related brain potential evidence for a response of inferior temporal cortex to familiar face repetitions. , 2002, Brain research. Cognitive brain research.

[47]  B. Breitmeyer,et al.  Recent models and findings in visual backward masking: A comparison, review, and update , 2000, Perception & psychophysics.

[48]  S. Bentin,et al.  Dissociated neural mechanisms for face detection and configural encoding: evidence from N170 and induced gamma-band oscillation effects. , 2007, Cerebral cortex.