The Correlations between Horizontal and Vertical Peripheral Refractions and Human Eye Shape Using Magnetic Resonance Imaging in Highly Myopic Eyes

The aim of this study was to determine the relationship between relative peripheral refraction and retinal shape by 2-D magnetic resonance imaging in high myopes. Thirty-five young adults aged 20 to 30 years participated in this study with 16 high myopes (spherical equivalent < −6.00 D) and 19 emmetropes (+0.50 to −0.50 D). An open field autorefractor was used to measure refractions from the center out to 60° in the horizontal meridian and out to around 20° in the vertical meridian, with a step of 3 degrees. Axial length was measured by using A-scan ultrasonography. In addition, images of axial, sagittal, and tangential sections were obtained using 2-D magnetic resonance imaging. The highly myopic group had a significantly relative peripheral hyperopic refraction and showed a prolate ocular shape compared to the emmetropic group. The highly myopic group had relative peripheral hyperopic refraction and showed a prolate ocular form. Significant differences in the ratios of height/axial (1.01 ± 0.02 vs. 0.94 ± 0.03) and width/axial (0.99 ± 0.17 vs. 0.93 ± 0.04) were found from the MRI images between the emmetropic and the highly myopic eyes (p < 0.001). There was a negative correlation between the retina’s curvature and relative peripheral refraction for both temporal (Pearson r = −0.459; p < 0.01) and nasal (Pearson r = −0.277; p = 0.011) retina. For the highly myopic eyes, the amount of peripheral hyperopic defocus is correlated to its ocular shape deformation. This could be the first study investigating the relationship between peripheral refraction and ocular dimension in high myopes, and it is hoped to provide useful knowledge of how the development of myopia changes human eye shape.

[1]  X. Zhong,et al.  Protective effects of sunlight exposure against PRK‐induced myopia in infant rhesus monkeys , 2021, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[2]  T. Wong,et al.  MRI of posterior eye shape and its associations with myopia and ethnicity , 2019, British Journal of Ophthalmology.

[3]  Lisa A. Ostrin,et al.  Optical mechanisms regulating emmetropisation and refractive errors: evidence from animal models , 2019, Clinical & experimental optometry.

[4]  C. K. Hsiao,et al.  Myopia among schoolchildren in East Asia and Singapore. , 2017, Survey of ophthalmology.

[5]  M. He,et al.  Three-Dimensional Eye Shape, Myopic Maculopathy, and Visual Acuity: The Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Cohort Study. , 2017, Ophthalmology.

[6]  D. Atchison,et al.  Three-dimensional MRI study of the relationship between eye dimensions, retinal shape and myopia. , 2017, Biomedical optics express.

[7]  Mingguang He,et al.  EPIDEMIC OF PATHOLOGIC MYOPIA: What Can Laboratory Studies and Epidemiology Tell Us? , 2017, Retina.

[8]  David A. Atchison,et al.  Peripheral Refraction, Peripheral Eye Length, and Retinal Shape in Myopia , 2016, Optometry and vision science : official publication of the American Academy of Optometry.

[9]  K. Naidoo,et al.  Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050. , 2016, Ophthalmology.

[10]  He Li,et al.  Relative Peripheral Hyperopia Does Not Predict Development and Progression of Myopia in Children. , 2015, Investigative ophthalmology & visual science.

[11]  Earl L. Smith,et al.  Effects of Local Myopic Defocus on Refractive Development in Monkeys , 2013, Optometry and vision science : official publication of the American Academy of Optometry.

[12]  Ryan P. McNabb,et al.  Correction of ocular shape in retinal optical coherence tomography and effect on current clinical measures. , 2013, American journal of ophthalmology.

[13]  D. Mutti,et al.  Time outdoors, visual activity, and myopia progression in juvenile-onset myopes. , 2012, Investigative ophthalmology & visual science.

[14]  I. Morita,et al.  Quantitative analyses of high-resolution 3D MR images of highly myopic eyes to determine their shapes. , 2012, Investigative ophthalmology & visual science.

[15]  D. Atchison.  The Glenn A. Fry Award Lecture 2011: Peripheral optics of the human eye. , 2012, Optometry and vision science : official publication of the American Academy of Optometry.

[16]  H. Iwata,et al.  Quantitative evaluation of changes in eyeball shape in emmetropization and myopic changes based on elliptic fourier descriptors. , 2011, Investigative ophthalmology & visual science.

[17]  S. Saw,et al.  Variations in eye volume, surface area, and shape with refractive error in young children by magnetic resonance imaging analysis. , 2011, Investigative ophthalmology & visual science.

[18]  I. Pacey,et al.  Cross-sectional sample of peripheral refraction in four meridians in myopes and emmetropes. , 2011, Investigative ophthalmology & visual science.

[19]  Karla Zadnik,et al.  Relative peripheral refractive error and the risk of onset and progression of myopia in children. , 2011, Investigative ophthalmology & visual science.

[20]  David A. Berntsen,et al.  Study of Theories about Myopia Progression (STAMP) Design and Baseline Data , 2010, Optometry and vision science : official publication of the American Academy of Optometry.

[21]  Hema Radhakrishnan,et al.  Peripheral refraction and the development of refractive error: a review , 2010, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[22]  Juan Tabernero,et al.  More irregular eye shape in low myopia than in emmetropia. , 2009, Investigative ophthalmology & visual science.

[23]  J. Sivak,et al.  Eyes of a lower vertebrate are susceptible to the visual environment. , 2007, Investigative ophthalmology & visual science.

[24]  David A. Atchison,et al.  Peripheral refraction along the horizontal and vertical visual fields in myopia , 2006, Vision Research.

[25]  R. Stone,et al.  Local Patterns of Image Degradation Differentially Affect Refraction and Eye Shape in Chick , 2006, Current eye research.

[26]  Jörgen Gustafsson,et al.  Off-axis wave front measurements for optical correction in eccentric viewing. , 2005, Journal of biomedical optics.

[27]  Larry N. Thibos,et al.  Retinal stretching limits peripheral visual acuity in myopia , 2005, Vision Research.

[28]  David A Atchison,et al.  Eye shape in emmetropia and myopia. , 2004, Investigative ophthalmology & visual science.

[29]  Bernard Gilmartin,et al.  Posterior retinal contour in adult human anisomyopia. , 2004, Investigative ophthalmology & visual science.

[30]  C K Hsiao,et al.  Prevalence of myopia in Taiwanese schoolchildren: 1983 to 2000. , 2004, Annals of the Academy of Medicine, Singapore.

[31]  R. Stone,et al.  Ocular shape and myopia. , 2004, Annals of the Academy of Medicine, Singapore.

[32]  Pablo Artal,et al.  Peripheral refractive errors in myopic, emmetropic, and hyperopic young subjects. , 2002, Journal of the Optical Society of America. A, Optics, image science, and vision.

[33]  D. Mutti,et al.  Peripheral refraction and ocular shape in children. , 2000, Investigative ophthalmology & visual science.

[34]  F. Schaeffel,et al.  Local Changes in Eye Growth induced by Imposed Local Refractive Error despite Active Accommodation , 1997, Vision Research.

[35]  Earl L. Smith,et al.  Spectacle lenses alter eye growth and the refractive status of young monkeys , 1995, Nature Medicine.

[36]  Josh Wallman,et al.  Choroidal and scleral mechanisms of compensation for spectacle lenses in chicks , 1995, Vision Research.

[37]  Manbir Nagra,et al.  Visual Psychophysics and Physiological Optics Shape of the Posterior Vitreous Chamber in Human Emmetropia and Myopia , 2013 .

[38]  M. Mischi,et al.  PERIPHERAL RETINAL CHANGES AND AXIAL MYOPIA , 1992, Retina.