Elucidating the Capabilities of Mirrorless Large Core Bundled Plastic Fiber Optic Displacement Sensor for Paracetamol Detection

A simple mirrorless plastic optical fiber displacement sensor was used to determine the concentration of paracetamol (PCM) in an aqueous solution. Paracetamol concentrations between 5 and 45 ppm were tested by the proposed sensor. With a mirror, the substantial sensitivity observed by an output power changed against displacement of 0.0403 mW/μm for the front slope and 0.023 mW/μm for the back slope with linearities of more than 99%. On the other hand, nonmirror reflector showed a sensitivity of 0.0006 mW/μm for the front slope and 0.0002 mW/μm for the back slope for the case of a red reflector and a sensitivity of 0.0007 mW/μm and 0.0003 mW/μm for the front and the back slope, respectively, for the case of a white reflector. The sensor sensitivity for the red and white coloured papers, which were used as the nonmirror reflectors and the mirror reflector itself against changing PCM concentrations, was 0.0004 mW/ppm, 0.0008 mW/ppm, and 0.02 mW/ppm, respectively. The experimental results indicated that the sensor was not only able to detect and measure the concentration of PCM in aqueous solutions but was also very stable with the additional advantages of a cost-effective and practical design that is highly beneficial for real-world sensing applications.

[1]  I. Boz,et al.  Electrochemical Sensing of Acetaminophen on Electrochemically Reduced Graphene Oxide-Nafion Composite Film Modified Electrode , 2013, International Journal of Electrochemical Science.

[2]  W. H. Stevenson,et al.  Refractive index of liquid solutions at low temperatures: an accurate measurement. , 1976, Applied optics.

[3]  S. A. Samsudin,et al.  Color detection using non‐target reflectivity plastic optical fiber displacement sensor , 2020, Microwave and Optical Technology Letters.

[4]  H. Arof,et al.  Intensity based optical fiber sensors for calcium detection , 2015 .

[5]  Hsuan‐Jung Huang,et al.  Chemiluminescence detection of paracetamol by a luminol-permanganate based reaction , 2001 .

[6]  Harith Ahmad,et al.  Fiber optic salinity sensor using beam-through technique , 2013 .

[7]  S. Harun,et al.  Fiber-Optic Salinity Sensor Using Fiber-Optic Displacement Measurement With Flat and Concave Mirror , 2012, IEEE Journal of Selected Topics in Quantum Electronics.

[8]  Jun Liu,et al.  A graphene-based electrochemical sensor for sensitive detection of paracetamol. , 2010, Talanta.

[9]  Jianmeng Chen,et al.  Paracetamol in the environment and its degradation by microorganisms , 2012, Applied Microbiology and Biotechnology.

[10]  E. Llorent-Martínez,et al.  Fluorimetric SIA optosensing in pharmaceutical analysis: determination of paracetamol. , 2007, Journal of pharmaceutical and biomedical analysis.

[11]  Adriano Joss,et al.  Oxidation of pharmaceuticals during ozonation of municipal wastewater effluents: a pilot study. , 2005, Environmental science & technology.

[12]  Noriah Bidin,et al.  Fiber optic displacement sensor for honey purity detection in distilled water , 2013 .

[13]  Hongying Lv,et al.  Fabrication of the protonated graphitic carbon nitride nanosheets as enhanced electrochemical sensing platforms for hydrogen peroxide and paracetamol detection , 2016 .

[14]  José Brandão Faria,et al.  A theoretical analysis of the bifurcated fiber bundle displacement sensor , 1998, IEEE Trans. Instrum. Meas..

[15]  Richard G Compton,et al.  Sensitive adsorptive stripping voltammetric determination of paracetamol at multiwalled carbon nanotube modified basal plane pyrolytic graphite electrode. , 2008, Analytica chimica acta.

[16]  G. Blaschke,et al.  Direct determination of paracetamol and its metabolites in urine and serum by capillary electrophoresis with ultraviolet and mass spectrometric detection. , 1999, Journal of chromatography. B, Biomedical sciences and applications.

[17]  W. Yunus,et al.  Refractive index of solutions at high concentrations. , 1988, Applied optics.

[18]  Yang Fan,et al.  Electrochemical behavior and voltammetric determination of paracetamol on Nafion/TiO2-graphene modified glassy carbon electrode. , 2011, Colloids and surfaces. B, Biointerfaces.

[19]  Xiaojing Lu,et al.  Electrochemical sensor for paracetamol recognition and detection based on catalytic and imprinted composite film. , 2015, Biosensors & bioelectronics.

[20]  Shih-Chieh Chang,et al.  Acute Response in vivo of a Fiber-Optic Sensor for Continuous Glucose Monitoring from Canine Studies on Point Accuracy , 2010, Sensors.

[21]  Suhariningsih,et al.  Fiber Optic Displacement Sensor for Measuring Cholesterol Concentration , 2017 .

[22]  Nadine Gottschalk,et al.  Fundamentals Of Photonics , 2016 .

[23]  P. Solich,et al.  Sequential injection chromatographic determination of paracetamol, caffeine, and acetylsalicylic acid in pharmaceutical tablets. , 2004, Journal of separation science.

[24]  Harith Ahmad,et al.  Fiber optic chemical sensor using fiber coupler probe based on intensity modulation for alcohol detection , 2011 .

[25]  D. Xiao,et al.  Detection of paracetamol by capillary electrophoresis with chemiluminescence detection , 2006 .

[26]  M. Yasin,et al.  Fiber bundle sensor for detection of formaldehyde concentration in fish , 2019, Optical Fiber Technology.

[27]  Howard Rosenbaum,et al.  Effects of reading proficiency on embedded stem priming in primary school children , 2021 .

[28]  L. Jing,et al.  Electrochemical behavior of acetaminophen and its detection on the PANI–MWCNTs composite modified electrode , 2007 .

[29]  C. Bourdeaux,et al.  Death from paracetamol overdose despite appropriate treatment with n-acetylcysteine , 2007, Emergency Medicine Journal.

[30]  Lauro T. Kubota,et al.  Separation and electrochemical detection of paracetamol and 4-aminophenol in a paper-based microfluidic device. , 2012, Analytica chimica acta.

[31]  Rajendra N. Goyal,et al.  Differential pulse voltammetric determination of paracetamol at nanogold modified indium tin oxide electrode , 2005 .

[32]  S. Harun,et al.  Simple fiber optic sensor based on tapered fiber for aliphatic alcohol detection , 2011 .

[33]  Stoyan Nihtianov,et al.  for Capacitive Sensors , 2011 .

[34]  William M. Lee Acetaminophen and the U.S. acute liver failure study group: Lowering the risks of hepatic failure , 2004, Hepatology.

[35]  Hairul Azhar Abdul-Rashid,et al.  The performance of a fiber optic displacement sensor for different types of probes and targets , 2007 .

[36]  L. Kubota,et al.  Effects of EDTA on signal stability during electrochemical detection of acetaminophen. , 2004, Journal of pharmaceutical and biomedical analysis.