The Course of Cognitive Decline in Older Persons: Results from the Longitudinal Aging Study Amsterdam

The course of cognitive functioning in older persons was studied over a period of 6 years. The first aim was to distinguish cognitive decline as a temporary state from progressive cognitive decline. The second aim was to identify predictors which may be useful in discriminating persons with temporary cognitive decline from persons with progressive cognitive decline at an early stage. Data were derived from the Longitudinal Aging Study Amsterdam (LASA), a population-based study in the Netherlands. The results show that 18.2% of the sample of older persons showed cognitive decline over a period of 3 years. Of this group, 44% recovered from cognitive decline or stayed stable in the next 3 years. Especially older age, memory complaints and an increase of cardiovascular diseases at follow-up predict further deterioration.

[1]  L. Bouter,et al.  Association between memory complaints and incident Alzheimer's disease in elderly people with normal baseline cognition. , 1999, The American journal of psychiatry.

[2]  M. Laakso,et al.  STABILITY OF AGE‐ASSOCIATED MEMORY IMPAIRMENT DURING A LONGITUDINAL POPULATION‐BASED STUDY , 1997, Journal of The American Geriatrics Society.

[3]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[4]  Michael D. Kopelman,et al.  Handbook of memory disorders , 1995 .

[5]  D. Hogan,et al.  Predicting Who Will Develop Dementia in a Cohort of Canadian Seniors , 2000, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[6]  J. van Limbeek,et al.  Criterion validity of the Center for Epidemiologic Studies Depression scale (CES-D): results from a community-based sample of older subjects in The Netherlands. , 1997, Psychological medicine.

[7]  C. Dufouil,et al.  Long-Term Benzodiazepine Use and Cognitive Decline in the Elderly: The Epidemiology of Vascular Aging Study , 2002, Journal of clinical psychopharmacology.

[8]  L M Bouter,et al.  Memory complaints and APOE-ε4 accelerate cognitive decline in cognitively normal elderly , 2001, Neurology.

[9]  G. Lautenschlager,et al.  Mediators of long-term memory performance across the life span. , 1996, Psychology and aging.

[10]  A. Mackinnon,et al.  The course of depression in the elderly: a longitudinal community-based study in Australia , 1997, Psychological Medicine.

[11]  E. Corder,et al.  Stroke and Apolipoprotein E &egr;4 Are Independent Risk Factors for Cognitive Decline: A Population-Based Study , 2000, Stroke.

[12]  Karen Ritchie,et al.  Classification criteria for mild cognitive impairment: A population-based validation study , 2001 .

[13]  K Yaffe,et al.  Is diabetes associated with cognitive impairment and cognitive decline among older women? Study of Osteoporotic Fractures Research Group. , 2000, Archives of internal medicine.

[14]  E. Tangalos,et al.  Mild Cognitive Impairment Clinical Characterization and Outcome , 1999 .

[15]  C. Jonker,et al.  The association between depressive symptoms and cognitive decline in community-dwelling elderly persons , 2000, Neurobiology of Aging.

[16]  M. Haan,et al.  The influence of diabetes, hypertension, and stroke on ethnic differences in physical and cognitive functioning in an ethnically diverse older population. , 1996, Annals of epidemiology.

[17]  Lars Bäckman,et al.  Differential evolution of cognitive impairment in nondemented older persons: results from the Kungsholmen Project. , 2002, The American journal of psychiatry.

[18]  D. A. Bennett,et al.  Natural history of mild cognitive impairment in older persons , 2002, Neurology.

[19]  D. Zaitchik,et al.  Predicting conversion to Alzheimer disease using standardized clinical information. , 2000, Archives of neurology.

[20]  K Yaffe,et al.  Depressive symptoms and cognitive decline in nondemented elderly women: a prospective study. , 1999, Archives of general psychiatry.

[21]  A. Mackinnon,et al.  Apolipoprotein E allele ∈4, dementia, and cognitive decline in a population sample , 1995, The Lancet.

[22]  K. Marder,et al.  Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment. , 1997, The American journal of psychiatry.

[23]  H. Amièva,et al.  Incidence and outcome of mild cognitive impairment in a population-based prospective cohort , 2002, Neurology.

[24]  B. Penninx,et al.  Self-reports and general practitioner information on the presence of chronic diseases in community dwelling elderly. A study on the accuracy of patients' self-reports and on determinants of inaccuracy. , 1996, Journal of clinical epidemiology.

[25]  J. Dartigues,et al.  Longitudinal analysis of the association between depressive symptomatology and cognitive deterioration. , 1996, American journal of epidemiology.

[26]  Pearl A. Dykstra,et al.  Living arrangements and social networks of older adults , 1996 .

[27]  T. Salthouse.  Attempted decomposition of age-related influences on two tests of reasoning. , 2001, Psychology and aging.

[28]  J. Jolles,et al.  The relation between morbidity and cognitive performance in a normal aging population. , 1998, The journals of gerontology. Series A, Biological sciences and medical sciences.

[29]  H. Lentzner.  Autonomy and well-being in the aging population: Concepts and design of the longitudinal aging study Amsterdam: Edited by D. J. H. Deeg, C. P. M. Knipscheer and W. van Tilburg. Institute of Gerontology, The Netherlands, 1993. 303 pp. U.S. $ , 1995 .

[30]  K. Marder,et al.  The validity of new memory complaints in the elderly. , 1997, Archives of neurology.