Intracoronary optical diagnostics current status, limitations, and potential.

Optical coherence tomography (OCT), is a novel intravascular imaging modality analogous to intravascular ultrasound but uses light instead of sound. This review details the background, development, and status of current investigation using OCT, and discusses advantages, limitations, and likely future developments. It provides indications for possible future clinical use, and places OCT in the context of current intravascular imaging in what is a rapidly changing field of investigation.

[1]  Brett E. Bouma,et al.  In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography , 2005, Circulation.

[2]  M. Takano,et al.  Advanced neointimal growth is not associated with a low risk of in-stent thrombus. Optical coherence tomographic findings after first-generation drug-eluting stent implantation. , 2009, Circulation journal : official journal of the Japanese Circulation Society.

[3]  T. Kume,et al.  Optical coherence tomography evaluation of zotarolimus-eluting stents at 9-month follow-up: comparison with sirolimus-eluting stents , 2009, Heart.

[4]  M. Takano,et al.  Comparison of neointimal coverage by optical coherence tomography of a sirolimus-eluting stent versus a bare-metal stent three months after implantation. , 2008, The American journal of cardiology.

[5]  Takahiko Suzuki,et al.  Neointimal coverage of sirolimus-eluting stents 6 months and 12 months after implantation: evaluation by optical coherence tomography. , 2008, Chinese medical journal.

[6]  B. Lv,et al.  In vivo optical coherence tomography of experimental thrombosis in a rabbit carotid model , 2007, Heart.

[7]  M. Sheppard,et al.  Optical coherence tomography for the assessment of pericardium covered stents for the treatment of degenerated saphenous vein grafts , 2010 .

[8]  Brett E Bouma,et al.  Challenges on the frontier of intracoronary imaging: atherosclerotic plaque macrophage measurement by optical coherence tomography. , 2010, Journal of biomedical optics.

[9]  Ruslan Hlushchuk,et al.  Coronary optical frequency domain imaging (OFDI) for in vivo evaluation of stent healing: comparison with light and electron microscopy , 2010, European heart journal.

[10]  Giuseppe Biondi-Zoccai,et al.  Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents. , 2010, JACC. Cardiovascular interventions.

[11]  Eiji Toyota,et al.  Assessment of coronary arterial plaque by optical coherence tomography. , 2006, The American journal of cardiology.

[12]  Aloke V. Finn,et al.  Delayed Arterial Healing and Increased Late Stent Thrombosis at Culprit Sites After Drug-Eluting Stent Placement for Acute Myocardial Infarction Patients: An Autopsy Study , 2008, Circulation.

[13]  P. Fitzgerald,et al.  Intravascular ultrasound assessment of the mechanisms and results of brachytherapy. , 2001, Circulation.

[14]  Udo Hoffmann,et al.  Diagnostic accuracy of optical coherence tomography and intravascular ultrasound for the detection and characterization of atherosclerotic plaque composition in ex-vivo coronary specimens: a comparison with histology , 2006, Coronary artery disease.

[15]  Brett E Bouma,et al.  Optical coherence tomography as a tool for percutaneous coronary interventions , 2005, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[16]  N. Weissman,et al.  Background Incidence of Late Malapposition After Bare-Metal Stent Implantation , 2002, Circulation.

[17]  J. Schmitt,et al.  OCT elastography: imaging microscopic deformation and strain of tissue. , 1998, Optics express.

[18]  Evelyn Regar,et al.  Fully automatic three‐dimensional quantitative analysis of intracoronary optical coherence tomography , 2009, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[19]  Teresa C. Chen,et al.  Polarization-sensitive Spectral-domain Optical Coherence Tomography Using a Single Line Scan Camera References and Links , 2022 .

[20]  B. Bouma,et al.  Association of statin therapy with reduced coronary plaque rupture: an optical coherence tomography study , 2008, Coronary artery disease.

[21]  G Tearney,et al.  Visualization of tissue prolapse between coronary stent struts by optical coherence tomography: comparison with intravascular ultrasound. , 2001, Circulation.

[22]  Nico de Jong,et al.  Robust intravascular optical coherence elastography by line correlations , 2007, Physics in medicine and biology.

[23]  I. Jang Optical coherence tomography or intravascular ultrasound? , 2011, JACC. Cardiovascular interventions.

[24]  Y. Jang,et al.  Comparison of neointimal coverage of sirolimus-eluting stents and paclitaxel-eluting stents using optical coherence tomography at 9 months after implantation. , 2010, Circulation journal : official journal of the Japanese Circulation Society.

[25]  Tae-Hoon Kim,et al.  Intracoronary thrombus formation after drug-eluting stents implantation: optical coherence tomographic study. , 2010, American heart journal.

[26]  Eloisa Arbustini,et al.  Sources of error and interpretation of plaque morphology by optical coherence tomography. , 2006, The American journal of cardiology.

[27]  T Akasaka,et al.  Cardiac optical coherence tomography , 2008, Heart.

[28]  Nicusor Iftimia,et al.  Focal and multi-focal plaque macrophage distributions in patients with acute and stable presentations of coronary artery disease. , 2004, Journal of the American College of Cardiology.

[29]  R. Virmani,et al.  Clinical Feasibility of Molecular Imaging of Plaque Inflammation in Atherosclerosis , 2009, Journal of Nuclear Medicine.

[30]  J. Schuman,et al.  Optical coherence tomography. , 2000, Science.

[31]  E. Halpern,et al.  Quantification of Macrophage Content in Atherosclerotic Plaques by Optical Coherence Tomography , 2003, Circulation.

[32]  K. Hirata,et al.  Comparison by optical coherence tomography of paclitaxel-eluting stents with sirolimus-eluting stents implanted in one coronary artery in one procedure. - 6-month follow-up -. , 2010, Circulation journal : official journal of the Japanese Circulation Society.

[33]  B. Dolan Optical Coherence Tomography of Ocular Diseases, 2nd ed , 2005 .

[34]  Benjamin J Vakoc,et al.  Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging. , 2008, JACC. Cardiovascular imaging.

[35]  N. Weissman,et al.  Frequency and severity of plaque prolapse within Cypher and Taxus stents as determined by sequential intravascular ultrasound analysis. , 2006, The American journal of cardiology.

[36]  R. Virmani,et al.  Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. , 1997, The New England journal of medicine.

[37]  Y. Iesaka,et al.  Assessment of acute injuries and chronic intimal thickening of the radial artery after transradial coronary intervention by optical coherence tomography. , 2010, European heart journal.

[38]  James G. Fujimoto,et al.  Optical Coherence Tomography of Ocular Diseases , 1995 .

[39]  K. Hirata,et al.  Optical coherence evaluation of everolimus-eluting stents 8 months after implantation , 2010, Heart.

[40]  Giuseppe Biondi-Zoccai,et al.  Strut coverage and vessel wall response to zotarolimus-eluting and bare-metal stents implanted in patients with ST-segment elevation myocardial infarction: the OCTAMI (Optical Coherence Tomography in Acute Myocardial Infarction) Study. , 2010, JACC. Cardiovascular interventions.

[41]  R. Virmani,et al.  Small black holes in optical frequency domain imaging matches intravascular neoangiogenesis formation in histology. , 2010, European heart journal.

[42]  Shaosong Zhang,et al.  Development of lipid-rich plaque inside bare metal stent: possible mechanism of late stent thrombosis? An optical coherence tomography study , 2010, Heart.

[43]  J G Fujimoto,et al.  Ultrahigh resolution optical coherence tomography of Barrett’s esophagus: preliminary descriptive clinical study correlating images with histology , 2007, Endoscopy.

[44]  J. Fujimoto,et al.  Three-dimensional endomicroscopy using optical coherence tomography , 2007 .

[45]  E Regar,et al.  Optical coherence tomography assessment of the acute effects of stent implantation on the vessel wall: a systematic quantitative approach , 2009, Heart.

[46]  M. Takano,et al.  Optical coherence tomography analysis for restenosis of drug-eluting stents. , 2011, International journal of cardiology.

[47]  Eloisa Arbustini,et al.  Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis. , 2010, European heart journal.

[48]  M. Brezinski Optical coherence tomography for identifying unstable coronary plaque. , 2006, International journal of cardiology.

[49]  P. Andersen,et al.  OCT imaging of skin cancer and other dermatological diseases , 2009, Journal of biophotonics.

[50]  P. Serruys,et al.  Three-year results of clinical follow-up after a bioresorbable everolimus-eluting scaffold in patients with de novo coronary artery disease: the ABSORB trial. , 2010, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.

[51]  Gijs van Soest,et al.  Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging. , 2010, Journal of biomedical optics.

[52]  R. Zawadzki,et al.  Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography. , 2003, Optics express.

[53]  Brett E Bouma,et al.  Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques. , 2006, Journal of the American College of Cardiology.

[54]  A. Rollins,et al.  Intracoronary optical coherence tomography: a comprehensive review clinical and research applications. , 2009, JACC. Cardiovascular interventions.

[55]  I. Jang,et al.  Pulmonary vascular changes in pulmonary hypertension: optical coherence tomography findings. , 2010, Circulation. Cardiovascular imaging.

[56]  Takahiko Suzuki,et al.  Safety and feasibility of an intravascular optical coherence tomography image wire system in the clinical setting. , 2008, The American journal of cardiology.

[57]  Kazushi Takemoto,et al.  Morphology of Exertion-Triggered Plaque Rupture in Patients With Acute Coronary Syndrome: An Optical Coherence Tomography Study , 2008, Circulation.

[58]  B E Bouma,et al.  Porcine coronary imaging in vivo by optical coherence tomography. , 2000, Acta cardiologica.

[59]  E. Halpern,et al.  Characterization of Human Atherosclerosis by Optical Coherence Tomography , 2002, Circulation.

[60]  J. Ormiston,et al.  Sorting out drug-eluting stents , 2010, The Lancet.

[61]  Armando Tellez,et al.  Accuracy of optical coherence tomography in the evaluation of neointimal coverage after stent implantation. , 2010, JACC. Cardiovascular imaging.

[62]  J. Schmitt,et al.  Thinking inside the graft: applications of optical coherence tomography in coronary artery bypass grafting. , 2007, Journal of biomedical optics.

[63]  Bin Liu,et al.  Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT). , 2006, International journal of cardiology.

[64]  K. Hirata,et al.  Delayed neointimalization on sirolimus-eluting stents: 6-month and 12-month follow up by optical coherence tomography. , 2009, Circulation journal : official journal of the Japanese Circulation Society.

[65]  Yoshihiko Seino,et al.  Appearance of lipid-laden intima and neovascularization after implantation of bare-metal stents extended late-phase observation by intracoronary optical coherence tomography. , 2009, Journal of the American College of Cardiology.

[66]  M. Brezinski,et al.  Quantitative optical coherence tomographic elastography: method for assessing arterial mechanical properties. , 2006, The British journal of radiology.

[67]  J. Tanigawa,et al.  The influence of strut thickness and cell design on immediate apposition of drug-eluting stents assessed by optical coherence tomography. , 2009, International journal of cardiology.

[68]  Eiji Toyota,et al.  Assessment of coronary arterial thrombus by optical coherence tomography. , 2006, The American journal of cardiology.

[69]  Joseph M Schmitt,et al.  Current and future developments in intracoronary optical coherence tomography imaging. , 2009, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.

[70]  Yoshinobu Morikawa,et al.  Long-term follow-up of neointimal coverage of sirolimus-eluting stents--evaluation with optical coherence tomography. , 2009, Circulation journal : official journal of the Japanese Circulation Society.

[71]  E. Halpern,et al.  Evaluation of intracoronary stenting by intravascular optical coherence tomography , 2003, Heart.

[72]  Yoshinobu Onuma,et al.  Relation between plaque type and dissections at the edges after stent implantation: an optical coherence tomography study. , 2011, International journal of cardiology.

[73]  Hiromasa Otake,et al.  Neointimal coverage of sirolimus-eluting stents at 6-month follow-up: evaluated by optical coherence tomography. , 2007, European heart journal.

[74]  Xiaogang Wang,et al.  A roadmap of clustering algorithms: finding a match for a biomedical application , 2008, Briefings Bioinform..

[75]  Gijs van Soest,et al.  Intracoronary optical coherence tomography and the evaluation of stents , 2009, Expert review of medical devices.

[76]  Wolfgang Wieser,et al.  Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second. , 2010, Optics express.

[77]  B X Chen,et al.  Neointimal coverage of bare-metal and sirolimus-eluting stents evaluated with optical coherence tomography , 2007, Heart.

[78]  J. Fujimoto,et al.  Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology. , 1996, Circulation.

[79]  K. Kozuma,et al.  Quantitative coronary optical coherence tomography image analysis for the signal attenuation observed in-stent restenotic tissue. , 2010, International journal of cardiology.

[80]  R. Virmani,et al.  Pathology of acute and chronic coronary stenting in humans. , 1999, Circulation.

[81]  Hiromasa Otake,et al.  Intriguing peri-strut low-intensity area detected by optical coherence tomography after coronary stent deployment. , 2010, Circulation journal : official journal of the Japanese Circulation Society.

[82]  Y. Neishi,et al.  Measurement of the thickness of the fibrous cap by optical coherence tomography. , 2006, American heart journal.

[83]  N Iftimia,et al.  OCT-based arterial elastography: robust estimation exploiting tissue biomechanics. , 2004, Optics express.

[84]  Youxin Mao,et al.  Feasibility of interstitial Doppler optical coherence tomography for in vivo detection of microvascular changes during photodynamic therapy , 2006, Lasers in surgery and medicine.

[85]  Patrick W. Serruys,et al.  Comparación cuantitativa ex vivo e in vivo de las dimensiones del lumen medidas por tomografía de coherencia óptica y ecografía intravascular en arterias coronarias humanas , 2009 .

[86]  Y. Iesaka,et al.  Impact of plaque morphology on creatine kinase-MB elevation in patients with elective stent implantation. , 2011, International journal of cardiology.

[87]  P. Serruys,et al.  An optical coherence tomography study of a biodegradable vs. durable polymer-coated limus-eluting stent: a LEADERS trial sub-study. , 2010, European heart journal.

[88]  Renu Virmani,et al.  Pathological Mechanisms of Fatal Late Coronary Stent Thrombosis in Humans , 2003, Circulation.

[89]  Gijs van Soest,et al.  Optical coherence tomography patterns of stent restenosis. , 2009, American heart journal.

[90]  P. Serruys,et al.  Quantitative ex vivo and in vivo comparison of lumen dimensions measured by optical coherence tomography and intravascular ultrasound in human coronary arteries. , 2009, Revista espanola de cardiologia.

[91]  Hiram G Bezerra,et al.  Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial , 2010, Heart.

[92]  Patrick W Serruys,et al.  A novel approach for quantitative analysis of intracoronary optical coherence tomography: High inter‐observer agreement with computer‐assisted contour detection , 2008, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[93]  K. Seung,et al.  Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound. , 2002, Journal of the American College of Cardiology.

[94]  K. Kodama,et al.  Atherosclerotic and thrombogenic neointima formed over sirolimus drug-eluting stent: an angioscopic study. , 2009, JACC. Cardiovascular imaging.

[95]  Masanori Yamamoto,et al.  Evaluation by optical coherence tomography of neointimal coverage of sirolimus-eluting stent three months after implantation. , 2007, The American journal of cardiology.

[96]  Peter Barlis,et al.  Quantitative analysis of intracoronary optical coherence tomography measurements of stent strut apposition and tissue coverage. , 2010, International journal of cardiology.

[97]  Renu Virmani,et al.  One step forward and two steps back with drug-eluting-stents: from preventing restenosis to causing late thrombosis and nouveau atherosclerosis. , 2009, JACC. Cardiovascular imaging.

[98]  Takashi Akasaka,et al.  Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy. , 2007, Journal of the American College of Cardiology.

[99]  Takashi Akasaka,et al.  Effect of statin therapy on coronary fibrous-cap thickness in patients with acute coronary syndrome: assessment by optical coherence tomography study. , 2009, Atherosclerosis.