Medication eluting devices for the field of OBGYN (MEDOBGYN): 3D printed biodegradable hormone eluting constructs, a proof of concept study

3D printing has the potential to deliver personalized implants and devices for obstetric and gynecologic applications. The aim of this study is to engineer customizable and biodegradable 3D printed implant materials that can elute estrogen and/or progesterone. All 3D constructs were printed using polycaprolactone (PCL) biodegradable polymer laden with estrogen or progesterone and were subjected to hormone-release profile studies using ELISA kits. Material thermal properties were tested using thermogravimetric analysis and differential scanning calorimetry. The 3D printed constructs showed extended hormonal release over a one week period. Cytocompatibility and bioactivity were assessed using a luciferase assay. The hormone-laden 3D printed constructs demonstrated an increase in luciferase activity and without any deleterious effects. Thermal properties of the PCL and hormones showed degradation temperatures above that of the temperature used in the additive manufacturing process–suggesting that 3D printing can be achieved below the degradation temperatures of the hormones. Sample constructs in the shape of surgical meshes, subdermal rods, intrauterine devices and pessaries were designed and printed. 3D printing of estrogen and progesterone-eluting constructs was feasible in this proof of concept study. These custom designs have the potential to act as a form of personalized medicine for drug delivery and optimized fit based on patient-specific anatomy.

[1]  Udayabhanu M. Jammalamadaka,et al.  Three‐dimensional printing of bioactive hernia meshes: In vitro proof of principle , 2017, Surgery.

[2]  Alexandra L Rutz,et al.  A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice , 2017, Nature Communications.

[3]  G. Baroni,et al.  3D-printed applicators for high dose rate brachytherapy: Dosimetric assessment at different infill percentage. , 2016, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[4]  M. Barber.  Pelvic organ prolapse , 2016, British Medical Journal.

[5]  Jean Pouliot,et al.  Clinical applications of custom-made vaginal cylinders constructed using three-dimensional printing technology , 2016, Journal of contemporary brachytherapy.

[6]  Charles Ascher-Walsh,et al.  Low Cost 3D Printing for the Creation of Cervical Cerclage Pessary Used to Prevent Preterm Birth: A Preliminary Study [26R] , 2016 .

[7]  W. Cohn,et al.  Innovative Use of 3D Printers in Gynecology , 2015 .

[8]  Udayabhanu M. Jammalamadaka,et al.  3D printing antibiotic and chemotherapeutic eluting catheters and constructs , 2015 .

[9]  Udayabhanu M. Jammalamadaka,et al.  Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications , 2015, International journal of nanomedicine.

[10]  Bethany C Gross,et al.  Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences. , 2014, Analytical chemistry.

[11]  Jim Banks,et al.  Adding Value in Additive Manufacturing : Researchers in the United Kingdom and Europe Look to 3D Printing for Customization , 2013, IEEE Pulse.

[12]  Leslie Mertz,et al.  Dream It, Design It, Print It in 3-D: What Can 3-D Printing Do for You? , 2013, IEEE Pulse.

[13]  B. Duan,et al.  3D bioprinting of heterogeneous aortic valve conduits with alginate/gelatin hydrogels. , 2013, Journal of biomedical materials research. Part A.

[14]  Xiaofeng Cui,et al.  Thermal inkjet printing in tissue engineering and regenerative medicine. , 2012, Recent patents on drug delivery & formulation.

[15]  E. Espey,et al.  Long-Acting Reversible Contraceptives: Intrauterine Devices and the Contraceptive Implant , 2011, Obstetrics and gynecology.

[16]  D. Cahill,et al.  Review of the safety, efficacy and patient acceptability of the levonorgestrel-releasing intrauterine system , 2008, Patient preference and adherence.

[17]  Barbara Roehl,et al.  Urinary Incontinence Evaluation and the Utility of Pessaries in Older Women , 2006, Care Management Journals.

[18]  J. Adam M. Cunha,et al.  Evaluation of PC-ISO for customized, 3D printed, gynecologic 192Ir HDR brachytherapy applicators. , 2015, Journal of applied clinical medical physics.

[19]  D. Edelman,et al.  Intrauterine Devices and Their Complications , 1979, Springer Netherlands.