Clinical Frailty Scale as a predictor of short‐term mortality: A systematic review and meta‐analysis of studies on diagnostic test accuracy

The Clinical Frailty Scale (CFS) is a representative frailty assessment tool in medicine. This systematic review and meta‐analysis aimed to examine whether frailty defined based on the CFS could adequately predict short‐term mortality in emergency department (ED) patients.

[1]  R. Bingisser,et al.  The clinical frailty scale predicts 1‐year mortality in emergency department patients aged 65 years and older , 2022, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[2]  Maura Kennedy,et al.  Do we really need another risk prediction rule? Yes, we do , 2022, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[3]  A. Nouvenne,et al.  Accounting for frailty and multimorbidity when interpreting high‐sensitivity troponin I tests in oldest old , 2021, Journal of the American Geriatrics Society.

[4]  B. Carter,et al.  Predicting 1 year mortality after traumatic injury using the Clinical Frailty Scale , 2021, Journal of the American Geriatrics Society.

[5]  Y. Saijo,et al.  Association between frailty and mortality among patients with accidental hypothermia: a nationwide observational study in Japan , 2021, BMC Geriatrics.

[6]  E. Mayo-Wilson,et al.  The PRISMA 2020 statement: an updated guideline for reporting systematic reviews , 2021, BMJ.

[7]  L. Forni,et al.  Clinical decision-making in older adults following emergency admission to hospital. Derivation and validation of a risk stratification score: OPERA , 2021, PloS one.

[8]  A. Brooks,et al.  The impact of frailty on trauma outcomes using the Clinical Frailty Scale , 2021, European Journal of Trauma and Emergency Surgery.

[9]  N. Takeyama,et al.  Association of frailty on treatment outcomes among patients with suspected infection treated at emergency departments , 2021, European journal of emergency medicine : official journal of the European Society for Emergency Medicine.

[10]  J. Perry,et al.  Association between mortality and frailty in emergency general surgery: a systematic review and meta-analysis , 2021, European Journal of Trauma and Emergency Surgery.

[11]  L. Hodgson,et al.  Agreement and predictive value of the Rockwood Clinical Frailty Scale at emergency department triage , 2020, Emergency Medicine Journal.

[12]  K. Rockwood,et al.  A scoping review of the Clinical Frailty Scale , 2020, BMC Geriatrics.

[13]  P. Braude,et al.  The Clinical Frailty Scale predicts adverse outcome in older people admitted to a UK major trauma centre. , 2020, Age and ageing.

[14]  S. Herget-Rosenthal,et al.  Validation of the Clinical Frailty Scale for retrospective use in acute care , 2020, European Geriatric Medicine.

[15]  N. Taub,et al.  Comparing associations between frailty and mortality in hospitalised older adults with or without COVID-19 infection: a retrospective observational study using electronic health records , 2020, Age and ageing.

[16]  L. Biant,et al.  Undertriage of the elderly major trauma patient continues in major trauma centre care: a retrospective cohort review , 2020, Emergency Medicine Journal.

[17]  D. Cook,et al.  Frailty and associated prognosis among older emergency department patients with suspected infection: A prospective, observational cohort study. , 2020, CJEM.

[18]  R. Bingisser,et al.  Validation of the Clinical Frailty Scale for Prediction of Thirty-Day Mortality in the Emergency Department. , 2020, Annals of emergency medicine.

[19]  E. Steyerberg,et al.  Geriatric Screening, Triage Urgency, and 30‐Day Mortality in Older Emergency Department Patients , 2020, Journal of the American Geriatrics Society.

[20]  Ashley Northcutt,et al.  Prospective Evaluation and Comparison of The Predictive Ability of Different Frailty Scores to Predict Outcomes in Geriatric Trauma Patients. , 2019, The journal of trauma and acute care surgery.

[21]  A. Nouvenne,et al.  Application of the Sepsis-3 Consensus Criteria in a Geriatric Acute Care Unit: A Prospective Study , 2019, Journal of clinical medicine.

[22]  K. Hillman,et al.  Which frailty scale for patients admitted via Emergency Department? A cohort study. , 2019, Archives of gerontology and geriatrics.

[23]  B. Haas,et al.  Canadian Study of Health and Aging Clinical Frailty Scale: Does It Predict Adverse Outcomes among Geriatric Trauma Patients? , 2017, Journal of the American College of Surgeons.

[24]  A. Mitnitski,et al.  Frailty affects the initial treatment response and time to recovery of mobility in acutely ill older adults admitted to hospital , 2017, Age and ageing.

[25]  M. Brabrand,et al.  Screening of the frail patient in the emergency department: A systematic review. , 2017, European journal of internal medicine.

[26]  E. Burkett,et al.  Frailty, thy name is… , 2017, Emergency medicine Australasia : EMA.

[27]  L. Ferrucci,et al.  Integrating Frailty Research into the Medical Specialties—Report from a U13 Conference , 2017, Journal of the American Geriatrics Society.

[28]  S. Conroy,et al.  Identifying frailty in the Emergency Department—feasibility study , 2017, Age and ageing.

[29]  K. Rockwood,et al.  A frailty index from common clinical and laboratory tests predicts increased risk of death across the life course , 2017, GeroScience.

[30]  J. Hewitt,et al.  Frailty as a predictor of mortality in the elderly emergency general surgery patient , 2017, Acta chirurgica Belgica.

[31]  S. Wallis,et al.  Clinical frailty adds to acute illness severity in predicting mortality in hospitalized older adults: An observational study. , 2016, European journal of internal medicine.

[32]  R. Biram,et al.  Association of the clinical frailty scale with hospital outcomes. , 2015, QJM : monthly journal of the Association of Physicians.

[33]  R. Bingisser,et al.  Undertriage in Older Emergency Department Patients – Tilting against Windmills? , 2014, PloS one.

[34]  L. Hooft,et al.  Investigation of publication bias in meta-analyses of diagnostic test accuracy: a meta-epidemiological study , 2014, BMC Medical Research Methodology.

[35]  Christopher R Carpenter,et al.  Understanding the direction of bias in studies of diagnostic test accuracy. , 2013, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[36]  Sharmila Bhattacharya,et al.  Physiological Changes Associated with Aging and Immobility , 2012, Journal of aging research.

[37]  C. Cairns,et al.  Accuracy of the Emergency Severity Index triage instrument for identifying elder emergency department patients receiving an immediate life-saving intervention. , 2010, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[38]  M. Bullard,et al.  Revisions to the Canadian Emergency Department Triage and Acuity Scale (CTAS) Guidelines 2016. , 2008, CJEM.

[39]  T. Strandberg,et al.  Frailty in elderly people , 2007, The Lancet.

[40]  I. McDowell,et al.  A global clinical measure of fitness and frailty in elderly people , 2005, Canadian Medical Association Journal.

[41]  Gordon Guyatt,et al.  Tips for learners of evidence-based medicine: 4. Assessing heterogeneity of primary studies in systematic reviews and whether to combine their results , 2005, Canadian Medical Association Journal.

[42]  Thomas McGinn,et al.  Tips for learners of evidence-based medicine: 3. Measures of observer variability (kappa statistic) , 2004, Canadian Medical Association Journal.

[43]  A. Mattu.  Geriatric Emergency Medicine. , 2003, Emergency medicine clinics of North America.

[44]  Matteo Cesari,et al.  The frailty phenotype and the frailty index: different instruments for different purposes. , 2014, Age and ageing.

[45]  M. Bullard,et al.  Revisions to the Canadian Emergency Department Triage and Acuity Scale (CTAS) Guidelines. , 2014, CJEM.

[46]  Hajime Orimo,et al.  [Reviewing the definition of elderly]. , 2006, Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.