Bioavailability determination of two crystal forms of sulfameter in humans from urinary excretion data.

Abstract Urinary excretion data were used to deter mine the bioavailability of crystal Forms II and III of sulfameter in humans. Agreement was observed between the ratio of absorption parameters of the two forms deter mined in the present study and those previously obtained from blood level data. Although the urine data revealed a significant difference in the rate of absorption of the two forms, no significant difference was observed in the extent of absorption of both forms as indicated by the 72-hr urinary excretion data. Urinary excretion rates during the absorption phase, without further mathematical treatment, were statistically shown to be adequate means for comparing the bioavailability of sulfameter crystal forms. The use of urinary excretion data of sulfameter as an alternative to the use of blood level data is discussed.