Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat

[1]  Peter Kraft,et al.  Adjusting for heritable covariates can bias effect estimates in genome-wide association studies. , 2015, American journal of human genetics.

[2]  F. Karpe,et al.  Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes , 2015, Nature Reviews Endocrinology.

[3]  Tamara S. Roman,et al.  New genetic loci link adipose and insulin biology to body fat distribution , 2014, Nature.

[4]  M. Blüher,et al.  Adipocyte dysfunction, inflammation and metabolic syndrome , 2014, Reviews in Endocrine and Metabolic Disorders.

[5]  J. Després,et al.  Ectopic visceral fat: A clinical and molecular perspective on the cardiometabolic risk , 2014, Reviews in Endocrine and Metabolic Disorders.

[6]  M. McCarthy,et al.  Distinct Developmental Profile of Lower-Body Adipose Tissue Defines Resistance Against Obesity-Associated Metabolic Complications , 2014, Diabetes.

[7]  I. Hwang,et al.  Associations between the GNB3 C825T polymorphism and obesity-related metabolic risk factors in Korean obese women , 2014, Journal of Endocrinological Investigation.

[8]  P. Raggi,et al.  Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis. , 2014, Atherosclerosis.

[9]  R. Loos,et al.  Genes and the Predisposition to Obesity , 2014 .

[10]  C. Bouchard,et al.  Genetic Component to Obesity: Evidence from Genetic Epidemiology , 2014 .

[11]  A. Mathie,et al.  Enhancement of TWIK-related Acid-sensitive Potassium Channel 3 (TASK3) Two-pore Domain Potassium Channel Activity by Tumor Necrosis Factor α , 2013, The Journal of Biological Chemistry.

[12]  Juan C. Vivar,et al.  Integrative pathway analysis of a genome-wide association study of (V)O(2max) response to exercise training. , 2013, Journal of applied physiology.

[13]  E. Hansson,et al.  Ultralow concentrations of bupivacaine exert anti-inflammatory effects on inflammation-reactive astrocytes , 2013, The European journal of neuroscience.

[14]  Richard T. Barfield,et al.  Mouse model implicates GNB3 duplication in a childhood obesity syndrome , 2013, Proceedings of the National Academy of Sciences.

[15]  T. Kitamoto,et al.  NUDT3 rs206936 is associated with body mass index in obese Japanese women. , 2013, Endocrine journal.

[16]  Mary K. Wojczynski,et al.  Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci , 2013, PLoS genetics.

[17]  F. Greenway,et al.  Clinical Utility and Reproducibility of Visceral Adipose Tissue Measurements Derived from Dual-energy X-ray Absorptiometry in White and African American Adults , 2013, Obesity.

[18]  Sandra D'Alfonso,et al.  Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls. , 2013, American journal of human genetics.

[19]  Ross M. Fraser,et al.  Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits , 2013, PLoS genetics.

[20]  M. Jensen,et al.  Mechanisms and metabolic implications of regional differences among fat depots. , 2013, Cell metabolism.

[21]  Inês Barroso,et al.  Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity , 2013, Nature Genetics.

[22]  Christian Gieger,et al.  Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture , 2013, Nature Genetics.

[23]  C. Bouchard,et al.  Clinical utility of visceral adipose tissue for the identification of cardiometabolic risk in white and African American adults. , 2013, The American journal of clinical nutrition.

[24]  T. Kitamoto,et al.  Replication study of 15 recently published Loci for body fat distribution in the Japanese population. , 2013, Journal of atherosclerosis and thrombosis.

[25]  Bart De Moor,et al.  An unbiased evaluation of gene prioritization tools , 2012, Bioinform..

[26]  M. Lee,et al.  Genetic and environmental relationships between Framingham Risk Score and adiposity measures in Koreans: the Healthy Twin study. , 2012, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[27]  Paula J. Griffin,et al.  Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women , 2012, PLoS genetics.

[28]  A. Swaroop,et al.  Knockdown of Bardet-Biedl Syndrome Gene BBS9/PTHB1 Leads to Cilia Defects , 2012, PloS one.

[29]  T. Kitamoto,et al.  Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography , 2012, Journal of Human Genetics.

[30]  Paul Brennan,et al.  Comparison of Pathway Analysis Approaches Using Lung Cancer GWAS Data Sets , 2012, PloS one.

[31]  T. Kitamoto,et al.  Genetic variations in the CYP17A1 and NT5C2 genes are associated with a reduction in visceral and subcutaneous fat areas in Japanese women , 2011, Journal of Human Genetics.

[32]  L. Pérusse,et al.  Individualized weight management: what can be learned from nutrigenomics and nutrigenetics? , 2012, Progress in molecular biology and translational science.

[33]  E. Lin,et al.  Association of the C825T polymorphism in the GNB3 gene with obesity and metabolic phenotypes in a Taiwanese population , 2012, Genes & Nutrition.

[34]  F. Agakov,et al.  Abundant pleiotropy in human complex diseases and traits. , 2011, American journal of human genetics.

[35]  T. Kitamoto,et al.  Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area , 2011, Journal of Human Genetics.

[36]  A. Liekens,et al.  BioGraph: unsupervised biomedical knowledge discovery via automated hypothesis generation , 2011, Genome Biology.

[37]  Suhua Chang,et al.  ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework , 2011, Nucleic Acids Res..

[38]  H. Hakonarson,et al.  Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation , 2011, Front. Gene..

[39]  H. Hakonarson,et al.  Analysing biological pathways in genome-wide association studies , 2010, Nature Reviews Genetics.

[40]  G. Abecasis,et al.  MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes , 2010, Genetic epidemiology.

[41]  Yusuke Nakamura,et al.  Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population , 2010, Journal of Human Genetics.

[42]  Thomas Meitinger,et al.  Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution , 2010, Nature Genetics.

[43]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[44]  Alkes L. Price,et al.  New approaches to population stratification in genome-wide association studies , 2010, Nature Reviews Genetics.

[45]  K. Lange,et al.  Prioritizing GWAS results: A review of statistical methods and recommendations for their application. , 2010, American journal of human genetics.

[46]  G. Bray,et al.  Racial differences in abdominal depot-specific adiposity in white and African American adults. , 2010, The American journal of clinical nutrition.

[47]  Xiping Xu,et al.  Genetic and Environmental Contributions to Phenotypic Components of Metabolic Syndrome: A Population‐based Twin Study , 2009, Obesity.

[48]  Laura J. Scott,et al.  Edinburgh Research Explorer Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution , 2022 .

[49]  Suzette J. Bielinski,et al.  NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium , 2009, PLoS genetics.

[50]  S. Stannard,et al.  Low Reproducibility Of Lactate Markers During Incremental Cycle Exercise: 1507 , 2009 .

[51]  Taesung Park,et al.  A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits , 2009, Nature Genetics.

[52]  V. Sheffield,et al.  Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling , 2009, Human molecular genetics.

[53]  C. Bouchard,et al.  The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. , 2009, Medicine and science in sports and exercise.

[54]  A. Uitterlinden,et al.  Sex-specific genetic effects influence variation in body composition , 2008, Diabetologia.

[55]  J. Després,et al.  Abdominal obesity: the cholesterol of the 21st century? , 2008, The Canadian journal of cardiology.

[56]  R. Hegele,et al.  Uncloaking the Genetic Determinants of Metabolic Syndrome , 2008, Lifestyle Genomics.

[57]  Robert Plomin,et al.  Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. , 2008, The American journal of clinical nutrition.

[58]  S. Gordon,et al.  The Differential Effects of Bupivacaine and Lidocaine on Prostaglandin E2 Release, Cyclooxygenase Gene Expression and Pain in a Clinical Pain Model , 2008, Anesthesia and analgesia.

[59]  V. Sheffield,et al.  A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis , 2007, Cell.

[60]  R. Bayoumi,et al.  Heritability of Determinants of the Metabolic Syndrome among Healthy Arabs of the Oman Family Study , 2007, Obesity.

[61]  C. Bouchard,et al.  Genetics of the metabolic syndrome. , 2007, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[62]  B. Balkau,et al.  Bardet-Biedl Syndrome Gene Variants Are Associated With Both Childhood and Adult Common Obesity in French Caucasians , 2006, Diabetes.

[63]  K. Taylor,et al.  Genetic Effects on Obesity Assessed by Bivariate Genome Scan: The Mexican‐American Coronary Artery Disease Study , 2006, Obesity.

[64]  D. Zurakowski,et al.  Effects of Bupivacaine and Tetrodotoxin on Carrageenan-induced Hind Paw Inflammation in Rats (Part 1): Hyperalgesia, Edema, and Systemic Cytokines , 2006, Anesthesiology.

[65]  C. Kahn,et al.  Evidence for a role of developmental genes in the origin of obesity and body fat distribution. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[66]  J. Pankow,et al.  Familial clustering for features of the metabolic syndrome: the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study. , 2006, Diabetes care.

[67]  C. Bouchard,et al.  The human gene map for performance and health-related fitness phenotypes: the 2005 update. , 2006, Medicine and science in sports and exercise.

[68]  R. Ozaki,et al.  Phenotypic and genetic clustering of diabetes and metabolic syndrome in Chinese families with type 2 diabetes mellitus , 2006, Diabetes/metabolism research and reviews.

[69]  Karine Clément,et al.  Genetics of human obesity. , 2006, The Proceedings of the Nutrition Society.

[70]  Edwin M Stone,et al.  Comparative genomics and gene expression analysis identifies BBS9, a new Bardet-Biedl syndrome gene. , 2005, American journal of human genetics.

[71]  Kaare Christensen,et al.  Total and regional fat distribution is strongly influenced by genetic factors in young and elderly twins. , 2005, Obesity research.

[72]  Gonçalo R. Abecasis,et al.  PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data , 2005, Bioinform..

[73]  R. Sacco,et al.  Heritabilities of the metabolic syndrome and its components in the Northern Manhattan Family Study , 2005, Diabetologia.

[74]  K. Lohman,et al.  Heritability of body composition measured by DXA in the diabetes heart study. , 2005, Obesity research.

[75]  P. Visscher,et al.  Twin study of genetic and environmental influences on adult body size, shape, and composition , 2004, International Journal of Obesity.

[76]  Lisa J. Martin,et al.  Phenotypic, genetic, and genome-wide structure in the metabolic syndrome , 2003, BMC Genetics.

[77]  P. Poulsen,et al.  Genetic versus environmental aetiology of the metabolic syndrome among male and female twins , 2001, Diabetologia.

[78]  A. Randall,et al.  Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel , 2001, Neuropharmacology.

[79]  C. Bouchard,et al.  Familial resemblance in fatness and fat distribution , 2000, American journal of human biology : the official journal of the Human Biology Council.

[80]  C. Bouchard,et al.  Familial aggregation of amount and distribution of subcutaneous fat and their responses to exercise training in the HERITAGE family study. , 2000, Obesity research.

[81]  J. Després,et al.  Total body fat and abdominal visceral fat response to exercise training in the HERITAGE Family Study: evidence for major locus but no multifactorial effects. , 1999, Metabolism: clinical and experimental.

[82]  C. Lewis,et al.  Racial differences in amounts of visceral adipose tissue in young adults: the CARDIA (Coronary Artery Risk Development in Young Adults) study. , 1999, The American journal of clinical nutrition.

[83]  C. Bouchard,et al.  Genetics of abdominal visceral fat levels , 1999, American journal of human biology : the official journal of the Human Biology Council.

[84]  C. Bouchard,et al.  Familial resemblance for abdominal visceral fat: the HERITAGE family study , 1997, International Journal of Obesity.

[85]  C. Bouchard Genetic determinants of regional fat distribution. , 1997, Human reproduction.

[86]  C. Bouchard,et al.  Familial aggregation of abdominal visceral fat level: results from the Quebec family study. , 1996, Metabolism: clinical and experimental.

[87]  C. Bouchard Genetic epidemiology, association, and sib-pair linkage: results from the Quebec Family Study , 1996 .

[88]  C. Bouchard,et al.  Familial aggregation of subcutaneous fat patterning: Principal components of skinfolds in the Québec family study , 1996, American journal of human biology : the official journal of the Human Biology Council.

[89]  C. Bouchard,et al.  Major gene influence on the propensity to store fat in trunk versus extremity depots: evidence from the Québec Family Study. , 1995, Obesity research.

[90]  C. Bouchard,et al.  The response to exercise with constant energy intake in identical twins. , 1994, Obesity research.

[91]  Y. Matsuzawa,et al.  Pathophysiology and pathogenesis of visceral fat obesity. , 1995, Annals of the New York Academy of Sciences.

[92]  C. Bouchard,et al.  Genetic and nongenetic determinants of regional fat distribution. , 1993, Endocrine reviews.

[93]  G. Bray,et al.  Basic and clinical aspects of regional fat distribution. , 1990, The American journal of clinical nutrition.

[94]  A Tremblay,et al.  The response to long-term overfeeding in identical twins. , 1990, The New England journal of medicine.

[95]  C. Bouchard,et al.  Assessment of adipose tissue distribution by computed axial tomography in obese women: association with body density and anthropometric measurements , 1989, British Journal of Nutrition.

[96]  C. Bouchard,et al.  Inheritance of the amount and distribution of human body fat. , 1988, International journal of obesity.

[97]  S B Hulley,et al.  CARDIA: study design, recruitment, and some characteristics of the examined subjects. , 1988, Journal of clinical epidemiology.

[98]  K. Pennert,et al.  Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. , 1984, British medical journal.

[99]  P. Björntorp,et al.  Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. , 1984, British medical journal.

[100]  A. Kissebah,et al.  Relation of Body Fat Distribution to Metabolic Complications of Obesity , 1982 .

[101]  J. Vague,et al.  The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. , 1956, The American journal of clinical nutrition.