Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

[1]  A. Sherman,et al.  Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis , 2007, Diabetologia.

[2]  M. Davidson Insulin Sensitivity of the Large Human Adipocyte in Vitro , 1975, Diabetes.

[3]  H. Vidal,et al.  Effect of carbohydrate overfeeding on whole body macronutrient metabolism and expression of lipogenic enzymes in adipose tissue of lean and overweight humans , 2004, International Journal of Obesity.

[4]  A. Kissebah,et al.  Relation of body fat distribution to metabolic complications of obesity. , 1982, The Journal of clinical endocrinology and metabolism.

[5]  M. Czech,et al.  Cellular basis of insulin insensitivity in large rat adipocytes. , 1976, The Journal of clinical investigation.

[6]  Y. Schutz,et al.  Concept of fat balance in human obesity revisited with particular reference to de novo lipogenesis , 2004, International Journal of Obesity.

[7]  A. Hamsten,et al.  Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance , 2008, Diabetologia.

[8]  L. Sjöström,et al.  Comparison of two methods for determining human adipose cell size. , 1972, Journal of lipid research.

[9]  M. Hellerstein,et al.  Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with 2H2O. , 2004, American journal of physiology. Endocrinology and metabolism.

[10]  F. Karpe,et al.  Transcriptional Control of Human Adipose Tissue Blood Flow , 2009, Obesity.

[11]  R. Turner,et al.  Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.

[12]  G. Reaven,et al.  Effects of age and obesity on insulin binding to isolated adipocytes. , 1975, Endocrinology.

[13]  F. Karpe,et al.  The effects of rosiglitazone on fatty acid and triglyceride metabolism in type 2 diabetes , 2004, Diabetologia.

[14]  P. Strålfors,et al.  Insulin-induced GLUT4 translocation to the plasma membrane is blunted in large compared with small primary fat cells isolated from the same individual , 2007, Diabetologia.

[15]  B. Fielding,et al.  Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. , 2008, Progress in lipid research.

[16]  M. Beylot,et al.  Differences in the regulation of adipose tissue and liver lipogenesis by carbohydrates in humans Published, JLR Papers in Press, February 1, 2003. DOI 10.1194/jlr.M200461-JLR200 , 2003, Journal of Lipid Research.

[17]  C. Bogardus,et al.  Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts Type II diabetes independent of insulin resistance , 2000, Diabetologia.

[18]  M. Garaulet,et al.  Relationship between fat cell size and number and fatty acid composition in adipose tissue from different fat depots in overweight/obese humans , 2006, International Journal of Obesity.

[19]  Fredrik Karpe,et al.  Preferential Uptake of Dietary Fatty Acids in Adipose Tissue and Muscle in the Postprandial Period , 2007, Diabetes.

[20]  G. Reaven,et al.  Effects of Age and Obesity on Insulin Binding to Isolated Adipocytes1212 , 1975 .

[21]  F. Renström,et al.  Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’ , 2007, Diabetologia.

[22]  U. Smith Effect of cell size on lipid synthesis by human adipose tissue in vitro. , 1971, Journal of lipid research.

[23]  G. Volpicelli,et al.  Insulin sensitivity indices calculated from basal and OGTT-induced insulin, glucose, and FFA levels. , 1998, Molecular genetics and metabolism.

[24]  J. Vinten,et al.  Lipogenesis and insulin sensitivity of single fat cells * , 1974, The Journal of physiology.

[25]  M. Hellerstein,et al.  The effect of dietary carbohydrate on genes for fatty acid synthase and inflammatory cytokines in adipose tissues from lean and obese subjects. , 2008, The Journal of nutritional biochemistry.

[26]  M. Fasshauer,et al.  Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes , 2007, Diabetologia.

[27]  J. Hirsch,et al.  The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity. , 1968, The Journal of clinical investigation.

[28]  E. Ravussin,et al.  Adipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus. , 2007, American journal of physiology. Endocrinology and metabolism.

[29]  P. Löfgren,et al.  Impaired subcutaneous adipocyte lipogenesis is associated with systemic insulin resistance and increased apolipoprotein B/AI ratio in men and women , 2007, Journal of internal medicine.

[30]  F. Karpe,et al.  Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding. , 2008, The American journal of clinical nutrition.

[31]  Fredrik Karpe,et al.  Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma. , 2005, Diabetes.

[32]  M. Beylot,et al.  Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity. , 2002, American journal of physiology. Endocrinology and metabolism.

[33]  P. Zimmet,et al.  Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation , 1998, Diabetic medicine : a journal of the British Diabetic Association.

[34]  R T Holman,et al.  Human subcutaneous adipose tissue shows site-specific differences in fatty acid composition. , 1994, The American journal of clinical nutrition.

[35]  Hubert C Chen,et al.  Determination of adipocyte size by computer image analysis. , 2002, Journal of lipid research.

[36]  S. Wootton,et al.  Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle. , 2002, Diabetes.

[37]  J. Hirsch,et al.  Effects of altered adipose tissue morphology on plasma insulin levels in the rat. , 1981, American Journal of Physiology.

[38]  M. Pfaffl,et al.  A new mathematical model for relative quantification in real-time RT-PCR. , 2001, Nucleic acids research.

[39]  M. Digirolamo,et al.  Metabolic patterns and insulin responsiveness of enlarging fat cells. , 1974, Journal of lipid research.

[40]  E. A. Sims,et al.  Glucose metabolism and the response to insulin by human adipose tissue in spontaneous and experimental obesity. Effects of dietary composition and adipose cell size. , 1974, The Journal of clinical investigation.

[41]  B. Lecka-Czernik,et al.  The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment Published, JLR Papers in Press, August 7, 2006. , 2006, Journal of Lipid Research.

[42]  V. Large,et al.  Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue Published, JLR Papers in Press, August 1, 2003. DOI 10.1194/jlr.M300235-JLR200 , 2003, Journal of Lipid Research.