Gene Targeting of Cytokines and the Mitogen-Activated Protein Kinase Pathways in Human Rheumatoid Synovium Using the Severe Combined Immunodeficiency Mouse Model
暂无分享,去创建一个
[1] W. B. Berg. Joint inflammation and cartilage destruction may occur uncoupled , 2004, Springer Seminars in Immunopathology.
[2] W. Mohr,et al. Proliferation of pannus tissue cells in rheumatoid arthritis , 2004, Rheumatology International.
[3] C. Gabay,et al. Treatment of rheumatoid arthritis with IL-1 inhibitors , 2004, Springer Seminars in Immunopathology.
[4] U. Müller-Ladner,et al. Delivery of antisense constructs and ribozymes to inhibit cartilage destruction in the SCID mouse model of RA , 2001, Arthritis Research.
[5] G. Firestein,et al. Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion. , 2001, Arthritis and rheumatism.
[6] P. Robbins,et al. Gene therapy for rheumatoid arthritis. , 2001, Expert opinion on biological therapy.
[7] G. Firestein,et al. Modulation of fibroblast-mediated cartilage degradation by articular chondrocytes in rheumatoid arthritis. , 2000, Arthritis and rheumatism.
[8] H. Ronday,et al. Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor. , 2000, Arthritis and rheumatism.
[9] R. Gay,et al. Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis. , 2000, Arthritis and rheumatism.
[10] R. Gay,et al. Gene transfer: from concept to therapy , 2000, Current opinion in rheumatology.
[11] U. Müller-Ladner,et al. Expression of sentrin, a novel antiapoptotic molecule, at sites of synovial invasion in rheumatoid arthritis. , 2000, Arthritis and rheumatism.
[12] Thomas Pap,et al. Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction , 1999, Arthritis research.
[13] H. Ronday,et al. Cartilage invasion by rheumatoid synovial fibroblasts in vivo is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor: abstract , 2000 .
[14] S. Santavirta,et al. Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis , 1999, Annals of the rheumatic diseases.
[15] A. Manning,et al. Jun N-terminal kinase in rheumatoid arthritis. , 1999, The Journal of pharmacology and experimental therapeutics.
[16] P. Petrow,et al. Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patients with rheumatoid arthritis. , 1999, Arthritis and rheumatism.
[17] C. Weyand,et al. T-cell responses in rheumatoid arthritis: systemic abnormalities-local disease. , 1999, Current opinion in rheumatology.
[18] F. Canovas,et al. Systemic viral interleukin-10 gene delivery prevents cartilage invasion by human rheumatoid synovial tissue engrafted in SCID mice. , 1999, Arthritis and rheumatism.
[19] G L Johnson,et al. Organization and regulation of mitogen-activated protein kinase signaling pathways. , 1999, Current opinion in cell biology.
[20] P. Robbins,et al. Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model. , 1999, Arthritis and rheumatism.
[21] R. Lafyatis,et al. Integrin engagement regulates proliferation and collagenase expression of rheumatoid synovial fibroblasts. , 1999, Journal of immunology.
[22] B. Bresnihan,et al. Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis. , 1999, Rheumatology.
[23] J. Dean,et al. Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor. , 1999, Biochemical Society symposium.
[24] R. Rau,et al. Clinical trials on biologics in rheumatoid arthritis. , 1998, International journal of clinical pharmacology and therapeutics.
[25] P. Petrow,et al. Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction. , 1998, The Journal of rheumatology.
[26] S. Gay,et al. Gene therapy in osteoarticular diseases: where are we? , 1998, Immunology today.
[27] E. Keystone,et al. IL-10 as a therapeutic strategy in the treatment of rheumatoid arthritis. , 1998, Rheumatic diseases clinics of North America.
[28] F. Breedveld,et al. Poor expression of T cell-derived cytokines and activation and proliferation markers in early rheumatoid synovial tissue. , 1998, Clinical immunology and immunopathology.
[29] U. Müller-Ladner,et al. Molecular biology of cartilage and bone destruction. , 1998, Current opinion in rheumatology.
[30] T. Ochi,et al. Possible correction of abnormal rheumatoid arthritis synovial cell function by jun D transfection in vitro. , 1998, Arthritis and rheumatism.
[31] S. Santavirta,et al. Synovial lining, endothelial and inflammatory mononuclear cell proliferation in synovial membranes in psoriatic and reactive arthritis: a comparative quantitative morphometric study. , 1998, British journal of rheumatology.
[32] A. Manning,et al. AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis. , 1998, Autoimmunity.
[33] J. Banchereau,et al. An update on interleukin-4 and its receptor. , 1997, European cytokine network.
[34] Y. Kaneda,et al. Ribozyme-based gene cleavage approach to chronic arthritis associated with human T cell leukemia virus type I: induction of apoptosis in synoviocytes by ablation of HTLV-I tax protein. , 1997, Arthritis and rheumatism.
[35] G. H. Rank,et al. Colocalization of antisense RNAs and ribozymes with their target mRNAs. , 1997, Genome.
[36] M. Lukoschek,et al. Differential expression and functional behaviour of the αv and β3 integrin subunits in cytokine stimulated fibroblast-like cells derived from synovial tissue of rheumatoid arthritis and osteoarthritis in vitro , 1997, Annals of the rheumatic diseases.
[37] C. Weyand,et al. The molecular basis of rheumatoid arthritis , 1997, Journal of Molecular Medicine.
[38] D. Green,et al. Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[39] S. Santavirta,et al. Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium. , 1997, Arthritis and rheumatism.
[40] E. Tindall,et al. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. , 1997, The New England journal of medicine.
[41] U. Müller-Ladner,et al. Cellular pathways of joint destruction. , 1997, Current opinion in rheumatology.
[42] P. Robbins,et al. Human IL-1Ra gene transfer into human synovial fibroblasts is chondroprotective. , 1997, Journal of immunology.
[43] L. Moreland,et al. Biologic agents for treating rheumatoid arthritis. Concepts and progress. , 1997, Arthritis and rheumatism.
[44] P. Emery,et al. Inhibition of T cell apoptosis in the rheumatoid synovium. , 1997, The Journal of clinical investigation.
[45] M. Lukoschek,et al. Increased expression of integrins on fibroblast-like synoviocytes from rheumatoid arthritis in vitro correlates with enhanced binding to extracellular matrix proteins , 1997, Annals of the rheumatic diseases.
[46] S. Nagataki,et al. TNF‐α‐mediated expression of membrane‐type matrix metalloproteinase in rheumatoid synovial fibroblasts , 1996, Immunology.
[47] G. Firestein. Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? , 1996, Arthritis and rheumatism.
[48] J. Kriegsmann,et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. , 1996, The American journal of pathology.
[49] P. Robbins. Gene therapy protocols , 1996 .
[50] H. Inoue,et al. Expression of Fas antigen and Fas ligand in the rheumatoid synovial tissue. , 1996, Clinical immunology and immunopathology.
[51] P. Isomäki,et al. The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis. , 1996, Arthritis and rheumatism.
[52] A. Koch,et al. Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis. , 1996, Arthritis and rheumatism.
[53] U. Müller-Ladner,et al. Ultrastructural demonstration of apoptosis, Fas and Bcl-2 expression of rheumatoid synovial fibroblasts. , 1996, The Journal of rheumatology.
[54] R. Spangler,et al. Cyclooxygenase 1 and 2 in rheumatic disease: implications for nonsteroidal anti-inflammatory drug therapy. , 1996, Seminars in arthritis and rheumatism.
[55] P. Lipsky,et al. A double-blind, placebo-controlled study of anti-CD5 immunoconjugate in patients with rheumatoid arthritis , 1996 .
[56] S. Yamashita,et al. Localisation of apoptosis and expression of apoptosis related proteins in the synovium of patients with rheumatoid arthritis. , 1996, Annals of the rheumatic diseases.
[57] Simon C Watkins,et al. Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis. , 1996, Human gene therapy.
[58] P. Robbins,et al. Pathways to gene therapy in rheumatoid arthritis. , 1996, Current opinion in rheumatology.
[59] M. Feldmann,et al. Role of cytokines in rheumatoid arthritis. , 1996, Annual review of immunology.
[60] J. Sinacore,et al. Recombinant human interleukin-1 receptor type I in the treatment of patients with active rheumatoid arthritis. , 1996, Arthritis and rheumatism.
[61] B. Manger,et al. Biologic agents in the treatment of inflammatory rheumatic diseases. , 1995, Current opinion in rheumatology.
[62] R. Kinne,et al. [Proliferation of T-cells, macrophages, neutrophilic granulocytes and fibroblast-like cells in the synovial membrane of patients with rheumatoid arthritis]. , 1996, Verhandlungen der Deutschen Gesellschaft fur Pathologie.
[63] T. Sawai,et al. Determination of interstitial collagenase (MMP-1) in patients with rheumatoid arthritis. , 1995, Annals of the rheumatic diseases.
[64] B. Dijkmans,et al. A randomized, double-blind, placebo-controlled study of CD4 monoclonal antibody therapy in early rheumatoid arthritis. , 1995, Arthritis and rheumatism.
[65] U. Müller-Ladner,et al. Oncogenes in rheumatoid arthritis. , 1995, Rheumatic diseases clinics of North America.
[66] E. Karran,et al. In vivo model of cartilage degradation--effects of a matrix metalloproteinase inhibitor. , 1995, Annals of the rheumatic diseases.
[67] P. Roux‐Lombard,et al. Dysregulation of the in vivo production of interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Pathogenetic implications. , 1995, Arthritis and rheumatism.
[68] D. Haskard,et al. Cell adhesion molecules in rheumatoid arthritis. , 1995, Current opinion in rheumatology.
[69] Brian Henderson,et al. Mechanisms and models in rheumatoid arthritis , 1995 .
[70] J. Dayer,et al. Inhibition of the production and effects of interleukins‐1 and tumor necrosis factor α in rheumatoid arthritis , 1995 .
[71] J. Banchereau,et al. Balance of IL-1 receptor antagonist/IL-1 beta in rheumatoid synovium and its regulation by IL-4 and IL-10. , 1995, Journal of immunology.
[72] F. O’Sullivan. 25 – Spontaneous Arthritis Models , 1995 .
[73] Panayi Gs. The pathogenesis of rheumatoid arthritis and the development of therapeutic strategies for the clinical investigation of biologics. , 1995 .
[74] C. Brinckerhoff,et al. Using inhibitors of metalloproteinases to treat arthritis. Easier said than done? , 1994, Arthritis and rheumatism.
[75] A. Levitzki,et al. Signal-transduction therapy. A novel approach to disease management. , 1994, European journal of biochemistry.
[76] Alexander Levitzki,et al. Signal-transduction therapy , 1994 .
[77] J. Kriegsmann,et al. A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice. , 1994, Arthritis and rheumatism.
[78] Ho As,et al. Interleukin-10 and its receptor. , 1994 .
[79] G. Firestein,et al. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. , 1994, Arthritis and rheumatism.
[80] M. Kohli,et al. Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia. Results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining. , 1994, Arthritis and rheumatism.
[81] M. Eichelberger,et al. Prominent usage of V beta 8.3 T cells in the H-2Db-restricted response to an influenza A virus nucleoprotein epitope. , 1993, Journal of immunology.
[82] A. Vladutiu,et al. The severe combined immunodeficient (SCID) mouse as a model for the study of autoimmune diseases , 1993, Clinical and experimental immunology.
[83] R. Gay,et al. Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction? , 1993, Annals of the rheumatic diseases.
[84] H. Hashimoto,et al. Beta 1 integrin-mediated interaction with extracellular matrix proteins regulates cytokine gene expression in synovial fluid cells of rheumatoid arthritis patients , 1993, The Journal of experimental medicine.
[85] J. Wilkins,et al. Beta 1 (CD29) integrin expression in rheumatoid synovial membranes: an immunohistologic study of distribution patterns. , 1993, The Journal of rheumatology.
[86] F. Sánchez‐Madrid,et al. The role of adhesion molecules in the pathogenesis of rheumatoid arthritis. , 1993, Autoimmunity.
[87] G. Firestein,et al. Stromelysin and tissue inhibitor of metalloproteinases gene expression in rheumatoid arthritis synovium. , 1992, The American journal of pathology.
[88] M. Harigai,et al. Interleukin 1 and tumor necrosis factor-alpha synergistically increase the production of interleukin 6 in human synovial fibroblast. , 1991, Journal of clinical & laboratory immunology.
[89] J. Mcghee,et al. Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis. , 1990, Matrix.
[90] K. Tomita,et al. Immunolocalization of matrix metalloproteinase 3 (stromelysin) in rheumatoid synovioblasts (B cells): correlation with rheumatoid arthritis. , 1989, Annals of the rheumatic diseases.
[91] Donald E. Mosier,et al. Transfer of a functional human immune system to mice with severe combined immunodeficiency , 1988, Nature.
[92] Y. Okada,et al. Matrix metalloproteinases 1, 2, and 3 from rheumatoid synovial cells are sufficient to destroy joints. , 1987, The Journal of rheumatology.
[93] H. Fassbender,et al. Histomorphological basis of articular cartilage destruction in rheumatoid arthritis. , 1983, Collagen and related research.
[94] C. Brinckerhoff,et al. Survival of rheumatoid synovium implanted into nude mice. , 1981, The American journal of pathology.
[95] Z. Werb,et al. Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator. , 1977, The New England journal of medicine.