Failure of noninvasive mechanical ventilation: could we assess determining factors in emergency department?

First, authors included hospitals that use heterogeneous NIV devices and interfaces. This could have influenced the results reported because technically, NIV devices present differences in their ability to leak compensations [3]. In addition, we have no clear information on other factors such as ventilatory modes and ventilator setup (pressure support ventilation or others), medium values of pressure inspiratory pressure-positive end expiratroy pressure, and tidal volume during NIV.

[1]  L. Leenen,et al.  Intubation after noninvasive ventilation failure in chronic obstructive pulmonary disease: associated factors at emergency department presentation , 2015, European journal of emergency medicine : official journal of the European Society for Emergency Medicine.

[2]  R. Scala.  Non-invasive ventilation in acute respiratory failure with altered consciousness syndrome: a bargain or an hazard? , 2013, Minerva anestesiologica.

[3]  K. H. Briones Claudett,et al.  Noninvasive mechanical ventilation with average volume assured pressure support (AVAPS) in patients with chronic obstructive pulmonary disease and hypercapnic encephalopathy , 2013, BMC Pulmonary Medicine.

[4]  J. Pépin,et al.  Intentional leaks in industrial masks have a significant impact on efficacy of bilevel noninvasive ventilation: a bench test study. , 2009, Chest.

[5]  P. Royston,et al.  Selection of important variables and determination of functional form for continuous predictors in multivariable model building , 2007, Statistics in medicine.

[6]  Philippe Jolliet,et al.  Performance of noninvasive ventilation modes on ICU ventilators during pressure support: a bench model study , 2007, Intensive Care Medicine.

[7]  O. Resta,et al.  Early and late failure of noninvasive ventilation in chronic obstructive pulmonary disease with acute exacerbation , 2005, European journal of clinical investigation.

[8]  M. Antonelli,et al.  A chart of failure risk for noninvasive ventilation in patients with COPD exacerbation , 2005, European Respiratory Journal.

[9]  R. Scala,et al.  Co-morbidity and acute decompensations of COPD requiring non-invasive positive-pressure ventilation , 2004, Intensive Care Medicine.

[10]  M. Pepe,et al.  Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker. , 2004, American journal of epidemiology.

[11]  J. Gillet,et al.  Non-invasive positive pressure ventilation for exacerbation of chronic obstructive pulmonary patients in the emergency department , 2001, European journal of emergency medicine : official journal of the European Society for Emergency Medicine.