Effects of Adding Resorbable Phosphate Glass Fibres and PLA to Calcium Phosphate Bone Cements

Background Calcium phosphate cements (CPCs), due to their biocompatibility and degradation properties, are being widely investigated as a replacement to more commonly used polymethylmethacrylate (PMMA) for vertebroplasty. CPCs have shown the potential to be replaced by host bone tissue during the healing/remodelling process. However, brittleness and comparatively low strength restrict the use of CPC in load-bearing applications. Although porous CPC can integrate with bone over time, slow degradation profiles and poor interconnectivity between pores restricts osseointegration to the top layer of CPC only. Methods Polylactic acid (PLA) and phosphate glass fibres (PGFs) were incorporated in a CPC matrix to overcome the problem of inherent brittleness and limited osseointegration. Results Incorporation of PLA and PGFs within CPC was successful in achieving a much less brittle CPC matrix without affecting the mechanical properties of CPC. The area under the stress-strain curve showed that the total energy to failure of the CPC hybrid was significantly greater than that of the CPC control. Conclusions The methodology adopted here to add PLA within the CPC matrix may also allow for incorporation of PLA cross-linked biochemicals. Micrographic studies revealed that it was possible to confer control over pore size, shape and interconnectivity without negatively affecting the mechanical properties of the cement. This tailorable porosity could potentially lead to better osseointegration within CPC.

[1]  C. Canal,et al.  Fibre-reinforced calcium phosphate cements: a review. , 2011, Journal of the mechanical behavior of biomedical materials.

[2]  Shu Cai,et al.  Preparation and properties of calcium phosphate cements incorporated gelatin microspheres and calcium sulfate dihydrate as controlled local drug delivery system , 2011, Journal of materials science. Materials in medicine.

[3]  J. Jansen,et al.  In vitro degradation rate of apatitic calcium phosphate cement with incorporated PLGA microspheres. , 2011, Acta biomaterialia.

[4]  Hua Liu,et al.  Kinetic Study of Calcium Phosphate Cement Containing Chitosan in Its Liquid Phase , 2010, 2010 4th International Conference on Bioinformatics and Biomedical Engineering.

[5]  Liang Zhao,et al.  Fatigue and human umbilical cord stem cell seeding characteristics of calcium phosphate-chitosan-biodegradable fiber scaffolds. , 2010, Biomaterials.

[6]  S. Dorozhkin Calcium Orthophosphate Cements and Concretes , 2009, Materials.

[7]  D. Steffey,et al.  Biomechanical evaluation of kyphoplasty with calcium phosphate cement in a 2-functional spinal unit vertebral compression fracture model. , 2008, The spine journal : official journal of the North American Spine Society.

[8]  Erich Schneider,et al.  Properties of an injectable low modulus PMMA bone cement for osteoporotic bone. , 2008, Journal of biomedical materials research. Part B, Applied biomaterials.

[9]  L. J. Valle,et al.  Injectable iron-modified apatitic bone cement intended for kyphoplasty: cytocompatibility study , 2008, Journal of materials science. Materials in medicine.

[10]  N. Dunne,et al.  Short-fibre reinforcement of calcium phosphate bone cement , 2007, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[11]  J. van den Dolder,et al.  Mechanical evaluation of implanted calcium phosphate cement incorporated with PLGA microparticles. , 2006, Biomaterials.

[12]  Alberto J Ambard,et al.  Calcium phosphate cement: review of mechanical and biological properties. , 2006, Journal of prosthodontics : official journal of the American College of Prosthodontists.

[13]  J A Planell,et al.  Calcium phosphate cements as bone drug delivery systems: a review. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[14]  Hockin H. K. Xu,et al.  Effects of synergistic reinforcement and absorbable fiber strength on hydroxyapatite bone cement. , 2005, Journal of biomedical materials research. Part A.

[15]  M. Bohner,et al.  Technological issues for the development of more efficient calcium phosphate bone cements: a critical assessment. , 2005, Biomaterials.

[16]  A. Boccaccini,et al.  Effect of iron on the surface, degradation and ion release properties of phosphate-based glass fibres. , 2005, Acta biomaterialia.

[17]  G. Baroud,et al.  Injectability of calcium phosphate pastes. , 2005, Biomaterials.

[18]  I Olsen,et al.  Processing, characterisation and biocompatibility of iron-phosphate glass fibres for tissue engineering. , 2004, Biomaterials.

[19]  C. Simon,et al.  Self-hardening calcium phosphate cement-mesh composite: reinforcement, macropores, and cell response. , 2004, Journal of biomedical materials research. Part A.

[20]  Sean Molloy,et al.  Temperature Measurement During Polymerization of Polymethylmethacrylate Cement Used for Vertebroplasty , 2003, Spine.

[21]  M. Gschwentner,et al.  Injectable calcium phosphate bone cement Norian SRS for the treatment of intra-articular compression fractures of the distal radius in osteoporotic women , 2003, Archives of Orthopaedic and Trauma Surgery.

[22]  玉井 宣行 Novel hydroxyapatite ceramics with an interconnective porous structure exhibit superior osteoconduction in vivo , 2003 .

[23]  J. Ledlie,et al.  Balloon kyphoplasty: one-year outcomes in vertebral body height restoration, chronic pain, and activity levels. , 2003, Journal of neurosurgery.

[24]  J. Déjou,et al.  Human biological reactions at the interface between bone tissue and polymethylmethacrylate cement , 2002, Journal of materials science. Materials in medicine.

[25]  J. Quinn,et al.  Calcium phosphate cement containing resorbable fibers for short-term reinforcement and macroporosity. , 2002, Biomaterials.

[26]  M. Bohner Physical and chemical aspects of calcium phosphates used in spinal surgery , 2001, European Spine Journal.

[27]  S. Best,et al.  Setting characteristics and mechanical behaviour of a calcium phosphate bone cement containing tetracycline. , 2001, Biomaterials.

[28]  Robert F. Wilson Surgery: Basic Science and Clinical Evidence , 2001 .

[29]  F. Eichmiller,et al.  Reinforcement of a self-setting calcium phosphate cement with different fibers. , 2000, Journal of biomedical materials research.

[30]  K. Hong,et al.  Osteoconduction at porous hydroxyapatite with various pore configurations. , 2000, Biomaterials.

[31]  R. Carrodeguas,et al.  Fiber reinforced calcium phosphate cement. , 2000, Artificial organs.

[32]  R. Poser,et al.  The correlation of radiographic, MRI and histologic evaluations over two years of a carbonated apatite cement in a rabbit model , 1999 .

[33]  E. Fernández,et al.  Precipitation of carbonated apatite in the cement system alpha-Ca(3)(PO(4))(2)-Ca(H(2)PO(4))(2)-CaCO(3). , 1999, Journal of biomedical materials research.

[34]  G. Lewis,et al.  Properties of acrylic bone cement: state of the art review. , 1997, Journal of biomedical materials research.

[35]  J. Antonucci,et al.  Polymeric calcium phosphate cements derived from poly(methyl vinyl ether-maleic acid). , 1996, Dental materials : official publication of the Academy of Dental Materials.

[36]  K. Asaoka,et al.  Estimation of ideal mechanical strength and critical porosity of calcium phosphate cement. , 1995, Journal of biomedical materials research.

[37]  Laurence C. Chow,et al.  Properties and mechanisms of fast-setting calcium phosphate cements , 1995 .

[38]  S A Goldstein,et al.  Skeletal repair by in situ formation of the mineral phase of bone. , 1995, Science.

[39]  J. Planell,et al.  Formulation and setting times of some calcium orthophosphate cements: a pilot study , 1993 .