Th17-mediated inflammation in asthma.
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[1] S. Brody,et al. IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia. , 2013, American journal of respiratory cell and molecular biology.
[2] P. Muranski,et al. Essentials of Th17 cell commitment and plasticity. , 2013, Blood.
[3] J. Kolls,et al. IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation , 2013, Thorax.
[4] Satoru Takahashi,et al. Transcription Factors GATA-3 and RORγt Are Important for Determining the Phenotype of Allergic Airway Inflammation in a Murine Model of Asthma , 2013, The Journal of Immunology.
[5] E. Kerwin,et al. A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Safety, Tolerability, and Efficacy of Brodalumab (AMG 827) in Subjects with Moderate to Severe Asthma , 2013 .
[6] Q. Hamid,et al. Th17‐associated cytokines promote human airway smooth muscle cell proliferation , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[7] J. Kolls,et al. IL-13 Regulates Th17 Secretion of IL-17A in an IL-10–Dependent Manner , 2012, The Journal of Immunology.
[8] D. Sheppard,et al. IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction , 2012, Nature Medicine.
[9] M. Schmidt,et al. Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients , 2011, Mucosal Immunology.
[10] J. Renauld,et al. IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation. , 2011, The Journal of allergy and clinical immunology.
[11] A. McKenzie,et al. Reciprocal expression of IL‐25 and IL‐17A is important for allergic airways hyperreactivity , 2011, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[12] N. Krug,et al. The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge. , 2011, The Journal of allergy and clinical immunology.
[13] Nicola A Hanania,et al. Lebrikizumab treatment in adults with asthma. , 2011, The New England journal of medicine.
[14] M. Willart,et al. Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. , 2011, American journal of respiratory and critical care medicine.
[15] L. Boulet,et al. Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma. , 2011, American journal of respiratory and critical care medicine.
[16] Q. Hamid,et al. TH17 cytokines induce human airway smooth muscle cell migration. , 2011, The Journal of allergy and clinical immunology.
[17] J. Kolls,et al. Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production. , 2011, The Journal of allergy and clinical immunology.
[18] J. Bluestone,et al. Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice. , 2010, The Journal of clinical investigation.
[19] J. Bernstein,et al. A novel subset of CD4+ TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma , 2010, The Journal of experimental medicine.
[20] Allergies During. A Randomized, Controlled Phase 2 Study of AMG 317, an IL-4Ralpha Antagonist, in Patients With Asthma , 2010 .
[21] M. Wills-Karp,et al. Complement-mediated Regulation Of The IL-17A Axis Is A Central Genetic Determinant Of The Severity Of Experimental Allergic Asthma , 2010, ATS 2010.
[22] Sally E Wenzel,et al. A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma. , 2010, American journal of respiratory and critical care medicine.
[23] J. Alcorn,et al. TH17 cells in asthma and COPD. , 2010, Annual review of physiology.
[24] Lorin Roskos,et al. A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma , 2010, BMC pulmonary medicine.
[25] V. Kuchroo,et al. Interleukin-17 and type 17 helper T cells. , 2009, The New England journal of medicine.
[26] R. Wu,et al. Regulation of Airway MUC5AC Expression by IL-1β and IL-17A; the NF-κB Paradigm1 , 2009, The Journal of Immunology.
[27] E. Matsui,et al. TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice , 2009, Pediatrics.
[28] Martin L. Moore,et al. A Functional IL-13 Receptor Is Expressed on Polarized Murine CD4+ Th17 Cells and IL-13 Signaling Attenuates Th17 Cytokine Production1 , 2009, The Journal of Immunology.
[29] J. Fahy,et al. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. , 2009, Proceedings of the American Thoracic Society.
[30] C. Lemière,et al. T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma. , 2009, The Journal of allergy and clinical immunology.
[31] Thomas Korn,et al. IL-17 and Th17 Cells. , 2009, Annual review of immunology.
[32] M. Hatano,et al. IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. , 2008, American journal of respiratory and critical care medicine.
[33] L. Borish,et al. Asthma: a syndrome composed of heterogeneous diseases. , 2008, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
[34] S. Phipps,et al. Eosinophils: Biological Properties and Role in Health and Disease , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[35] M. Fei,et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia , 2008, Nature Medicine.
[36] S. Wenzel,et al. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies , 2007, The Lancet.
[37] Yong‐jun Liu,et al. Interleukin 25 promotes the initiation of proallergic type 2 responses , 2007, The Journal of experimental medicine.
[38] J. Ross,et al. Identification of an Interleukin 17F/17A Heterodimer in Activated Human CD4+ T Cells* , 2007, Journal of Biological Chemistry.
[39] B. Ryffel,et al. Interleukin-17 is a negative regulator of established allergic asthma , 2006, The Journal of experimental medicine.
[40] S. Wenzel. Asthma: defining of the persistent adult phenotypes , 2006, The Lancet.
[41] R. Grencis. Faculty Opinions recommendation of Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. , 2005 .
[42] R. D. Hatton,et al. Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages , 2005, Nature Immunology.
[43] B. Graham,et al. Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels. , 2005, The Journal of allergy and clinical immunology.
[44] B. Graham,et al. Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5. , 2004, American journal of respiratory and critical care medicine.
[45] L. Boulet,et al. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. , 2003, The Journal of allergy and clinical immunology.
[46] W. Pierzchała,et al. Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. , 2003, Respiratory medicine.
[47] Y. Ho,et al. Stimulation of Airway Mucin Gene Expression by Interleukin (IL)-17 through IL-6 Paracrine/Autocrine Loop* , 2003, The Journal of Biological Chemistry.
[48] G. Hershey. IL-13 receptors and signaling pathways: an evolving web. , 2003, The Journal of allergy and clinical immunology.
[49] Q. Hamid,et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. , 2001, The Journal of allergy and clinical immunology.
[50] L. Cosmi,et al. Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4. , 2010, The Journal of allergy and clinical immunology.