Th17-mediated inflammation in asthma.

[1]  S. Brody,et al.  IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia. , 2013, American journal of respiratory cell and molecular biology.

[2]  P. Muranski,et al.  Essentials of Th17 cell commitment and plasticity. , 2013, Blood.

[3]  J. Kolls,et al.  IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation , 2013, Thorax.

[4]  Satoru Takahashi,et al.  Transcription Factors GATA-3 and RORγt Are Important for Determining the Phenotype of Allergic Airway Inflammation in a Murine Model of Asthma , 2013, The Journal of Immunology.

[5]  E. Kerwin,et al.  A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Safety, Tolerability, and Efficacy of Brodalumab (AMG 827) in Subjects with Moderate to Severe Asthma , 2013 .

[6]  Q. Hamid,et al.  Th17‐associated cytokines promote human airway smooth muscle cell proliferation , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[7]  J. Kolls,et al.  IL-13 Regulates Th17 Secretion of IL-17A in an IL-10–Dependent Manner , 2012, The Journal of Immunology.

[8]  D. Sheppard,et al.  IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction , 2012, Nature Medicine.

[9]  M. Schmidt,et al.  Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients , 2011, Mucosal Immunology.

[10]  J. Renauld,et al.  IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation. , 2011, The Journal of allergy and clinical immunology.

[11]  A. McKenzie,et al.  Reciprocal expression of IL‐25 and IL‐17A is important for allergic airways hyperreactivity , 2011, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[12]  N. Krug,et al.  The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge. , 2011, The Journal of allergy and clinical immunology.

[13]  Nicola A Hanania,et al.  Lebrikizumab treatment in adults with asthma. , 2011, The New England journal of medicine.

[14]  M. Willart,et al.  Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. , 2011, American journal of respiratory and critical care medicine.

[15]  L. Boulet,et al.  Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma. , 2011, American journal of respiratory and critical care medicine.

[16]  Q. Hamid,et al.  TH17 cytokines induce human airway smooth muscle cell migration. , 2011, The Journal of allergy and clinical immunology.

[17]  J. Kolls,et al.  Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production. , 2011, The Journal of allergy and clinical immunology.

[18]  J. Bluestone,et al.  Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice. , 2010, The Journal of clinical investigation.

[19]  J. Bernstein,et al.  A novel subset of CD4+ TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma , 2010, The Journal of experimental medicine.

[20]  Allergies During A Randomized, Controlled Phase 2 Study of AMG 317, an IL-4Ralpha Antagonist, in Patients With Asthma , 2010 .

[21]  M. Wills-Karp,et al.  Complement-mediated Regulation Of The IL-17A Axis Is A Central Genetic Determinant Of The Severity Of Experimental Allergic Asthma , 2010, ATS 2010.

[22]  Sally E Wenzel,et al.  A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma. , 2010, American journal of respiratory and critical care medicine.

[23]  J. Alcorn,et al.  TH17 cells in asthma and COPD. , 2010, Annual review of physiology.

[24]  Lorin Roskos,et al.  A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma , 2010, BMC pulmonary medicine.

[25]  V. Kuchroo,et al.  Interleukin-17 and type 17 helper T cells. , 2009, The New England journal of medicine.

[26]  R. Wu,et al.  Regulation of Airway MUC5AC Expression by IL-1β and IL-17A; the NF-κB Paradigm1 , 2009, The Journal of Immunology.

[27]  E. Matsui,et al.  TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice , 2009, Pediatrics.

[28]  Martin L. Moore,et al.  A Functional IL-13 Receptor Is Expressed on Polarized Murine CD4+ Th17 Cells and IL-13 Signaling Attenuates Th17 Cytokine Production1 , 2009, The Journal of Immunology.

[29]  J. Fahy,et al.  Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. , 2009, Proceedings of the American Thoracic Society.

[30]  C. Lemière,et al.  T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma. , 2009, The Journal of allergy and clinical immunology.

[31]  Thomas Korn,et al.  IL-17 and Th17 Cells. , 2009, Annual review of immunology.

[32]  M. Hatano,et al.  IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. , 2008, American journal of respiratory and critical care medicine.

[33]  L. Borish,et al.  Asthma: a syndrome composed of heterogeneous diseases. , 2008, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[34]  S. Phipps,et al.  Eosinophils: Biological Properties and Role in Health and Disease , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[35]  M. Fei,et al.  IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia , 2008, Nature Medicine.

[36]  S. Wenzel,et al.  Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies , 2007, The Lancet.

[37]  Yong‐jun Liu,et al.  Interleukin 25 promotes the initiation of proallergic type 2 responses , 2007, The Journal of experimental medicine.

[38]  J. Ross,et al.  Identification of an Interleukin 17F/17A Heterodimer in Activated Human CD4+ T Cells* , 2007, Journal of Biological Chemistry.

[39]  B. Ryffel,et al.  Interleukin-17 is a negative regulator of established allergic asthma , 2006, The Journal of experimental medicine.

[40]  S. Wenzel Asthma: defining of the persistent adult phenotypes , 2006, The Lancet.

[41]  R. Grencis Faculty Opinions recommendation of Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. , 2005 .

[42]  R. D. Hatton,et al.  Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages , 2005, Nature Immunology.

[43]  B. Graham,et al.  Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels. , 2005, The Journal of allergy and clinical immunology.

[44]  B. Graham,et al.  Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5. , 2004, American journal of respiratory and critical care medicine.

[45]  L. Boulet,et al.  Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. , 2003, The Journal of allergy and clinical immunology.

[46]  W. Pierzchała,et al.  Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. , 2003, Respiratory medicine.

[47]  Y. Ho,et al.  Stimulation of Airway Mucin Gene Expression by Interleukin (IL)-17 through IL-6 Paracrine/Autocrine Loop* , 2003, The Journal of Biological Chemistry.

[48]  G. Hershey IL-13 receptors and signaling pathways: an evolving web. , 2003, The Journal of allergy and clinical immunology.

[49]  Q. Hamid,et al.  IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. , 2001, The Journal of allergy and clinical immunology.

[50]  L. Cosmi,et al.  Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4. , 2010, The Journal of allergy and clinical immunology.