Demonstration of full 4×4 Mueller polarimetry through an optical fiber for endoscopic applications.

A novel technique to measure the full 4 × 4 Mueller matrix of a sample through an optical fiber is proposed, opening the way for endoscopic applications of Mueller polarimetry for biomedical diagnosis. The technique is based on two subsequent Mueller matrices measurements: one for characterizing the fiber only, and another for the assembly of fiber and sample. From this differential measurement, we proved theoretically that the polarimetric properties of the sample can be deduced. The proof of principle was experimentally validated by measuring various polarimetric parameters of known optical components. Images of manufactured and biological samples acquired by using this approach are also presented.

[1]  Ji Qi,et al.  A high definition Mueller polarimetric endoscope for tissue characterisation , 2016, Scientific reports.

[2]  Antonello De Martino,et al.  Application of Spectroscopic Ellipsometry and Mueller Ellipsometry to Optical Characterization , 2012, Applied spectroscopy.

[3]  B. Drévillon,et al.  General and self-consistent method for the calibration of polarization modulators, polarimeters, and mueller-matrix ellipsometers. , 1999, Applied optics.

[4]  Juan Campos,et al.  Optimization and tolerance analysis of a polarimeter with ferroelectric liquid crystals. , 2013, Applied optics.

[5]  A. Hideur,et al.  Measurement of the elliptical birefringence of single-mode optical fibers. , 2001, Applied optics.

[6]  Michael S. Feld,et al.  Imaging human epithelial properties with polarized light-scattering spectroscopy , 2001, Nature Medicine.

[7]  Ji Qi,et al.  Narrow band 3 × 3 Mueller polarimetric endoscopy. , 2013, Biomedical optics express.

[8]  Marc Van Barel,et al.  Eigenvalue computation for unitary rank structured matrices , 2008 .

[9]  Zhongping Chen,et al.  Use of polar decomposition for the diagnosis of oral precancer. , 2007, Applied optics.

[10]  R. Chipman,et al.  Interpretation of Mueller matrices based on polar decomposition , 1996 .

[11]  Dominique Pagnoux,et al.  Fiber-optic device for endoscopic polarization imaging. , 2009, Optics letters.

[12]  Mehdi Alouini,et al.  Depolarization remote sensing by orthogonality breaking. , 2012, Physical review letters.

[13]  Angelo Pierangelo,et al.  Polarimetric imaging of uterine cervix: a case study. , 2013, Optics express.

[14]  Bernard Le Jeune,et al.  Mueller matrix polarimetry for improved liver fibrosis diagnosis. , 2012, Optics letters.

[15]  J. Walsh,et al.  Quantitative measurements of linear birefringence during heating of native collagen , 1997, Lasers in surgery and medicine.

[16]  A. Pierangelo,et al.  Ex-vivo characterization of human colon cancer by Mueller polarimetric imaging. , 2011, Optics express.

[17]  Bernard Le Jeune,et al.  Snapshot Mueller matrix polarimeter by wavelength polarization coding. , 2007, Optics express.

[18]  Nirmalya Ghosh,et al.  Tissue polarimetry: concepts, challenges, applications, and outlook. , 2011, Journal of biomedical optics.

[19]  Jessica C Ramella-Roman,et al.  Imaging skin pathology with polarized light. , 2002, Journal of biomedical optics.

[20]  Arthur Lompado,et al.  Mueller matrix imaging polarimetry in dermatology , 2000, Photonics West - Biomedical Optics.

[21]  Linda T. Nieman,et al.  Fiber optic probe for polarized reflectance spectroscopy in vivo: design and performance. , 2002, Journal of biomedical optics.