Evaluation of potential role of Atp5g3 in modulating alcohol preference and obesity

Background Mitochondrial ATP synthase, subunit c, isoform 3 (Atp5g3), encodes subunit 9 of a multisubunit enzyme that catalyzes the synthesis of ATP during oxidative phosphorylation. Each ATP synthase complex has multiple copies of subunit 9 in its transmembrane portion (Fo). While much is known about the molecular mechanisms and function of this complex in the mitochondrial membrane, the impact of variants in this complex and its connection to other pathways and human diseases and disorders is unknown.