Barriers to Drug Distribution into the Perinatal and Postnatal Brain

[1]  N. Saunders,et al.  Brain barriers and functional interfaces with sequential appearance of ABC efflux transporters during human development , 2017, Scientific Reports.

[2]  D. Andropoulos Effect of Anesthesia on the Developing Brain: Infant and Fetus , 2017, Fetal Diagnosis and Therapy.

[3]  M. Rieder,et al.  Adverse Drug Reactions in Children: The Double‐Edged Sword of Therapeutics , 2017, Clinical pharmacology and therapeutics.

[4]  P. Colditz,et al.  Review: The blood-brain barrier; protecting the developing fetal brain. , 2017, Placenta.

[5]  Xiaolu Tang,et al.  Extracellular space diffusion analysis in the infant and adult rat striatum using magnetic resonance imaging , 2016, International Journal of Developmental Neuroscience.

[6]  J. Ghersi-Egea,et al.  Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier , 2016, Current pharmaceutical design.

[7]  I. Choonara,et al.  Systematic review of paediatric studies of adverse drug reactions from pharmacovigilance databases , 2016, Expert opinion on drug safety.

[8]  M. Iqbal,et al.  Astrocyte‐mediated regulation of multidrug resistance p‐glycoprotein in fetal and neonatal brain endothelial cells: age‐dependent effects , 2016, Physiological reports.

[9]  M. Iqbal,et al.  Regulation of Multidrug Resistance P‐Glycoprotein in the Developing Blood–Brain Barrier: Interplay between Glucocorticoids and Cytokines , 2016, Journal of neuroendocrinology.

[10]  I. Choonara,et al.  Learning Lessons from Adverse Drug Reactions in Children , 2016, Children.

[11]  S. Liebner,et al.  Multiple Antenatal Dexamethasone Treatment Alters Brain Vessel Differentiation in Newborn Mouse Pups , 2015, PloS one.

[12]  J. Ghersi-Egea,et al.  Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study , 2015, Front. Neurosci..

[13]  J. Ghersi-Egea,et al.  Changes in the cerebrospinal fluid circulatory system of the developing rat: quantitative volumetric analysis and effect on blood-CSF permeability interpretation , 2015, Fluids and Barriers of the CNS.

[14]  J. Ghersi-Egea,et al.  Blood-brain barrier dysfunction in disorders of the developing brain , 2015, Front. Neurosci..

[15]  R. Johnson,et al.  The domestic piglet: an important model for investigating the neurodevelopmental consequences of early life insults. , 2015, Annual review of animal biosciences.

[16]  J. Ghersi-Egea,et al.  Efflux transporters in blood-brain interfaces of the developing brain , 2015, Front. Neurosci..

[17]  Z. Vexler,et al.  Barrier mechanisms in neonatal stroke , 2014, Front. Neurosci..

[18]  B. Thyagarajan,et al.  Cotrimoxazole and neonatal kernicterus: a review , 2014, Drug and chemical toxicology.

[19]  Munir Pirmohamed,et al.  Adverse drug reactions and off-label and unlicensed medicines in children: a nested case?control study of inpatients in a pediatric hospital , 2013, BMC Medicine.

[20]  J. Ghersi-Egea,et al.  Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection , 2013, Fluids and Barriers of the CNS.

[21]  J. Ghersi-Egea,et al.  Mechanisms That Determine the Internal Environment of the Developing Brain: A Transcriptomic, Functional and Ultrastructural Approach , 2013, PloS one.

[22]  M. Pirmohamed,et al.  Transport of gabapentin by LAT1 (SLC7A5). , 2013, Biochemical pharmacology.

[23]  M. Khrestchatisky,et al.  Medicinal Chemistry Based Approaches and Nanotechnology‐Based Systems to Improve CNS Drug Targeting and Delivery , 2013, Medicinal research reviews.

[24]  B. Finlay,et al.  Modeling Transformations of Neurodevelopmental Sequences across Mammalian Species , 2013, The Journal of Neuroscience.

[25]  J. Ghersi-Egea,et al.  Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules. , 2013, Molecular pharmaceutics.

[26]  J. Ghersi-Egea,et al.  Complexity and developmental changes in the expression pattern of claudins at the blood–CSF barrier , 2012, Histochemistry and Cell Biology.

[27]  M. Wendland,et al.  Blood–Brain Barrier Permeability Is Increased After Acute Adult Stroke But Not Neonatal Stroke in the Rat , 2012, The Journal of Neuroscience.

[28]  Su Golder,et al.  Adverse Drug Reactions in Children—A Systematic Review , 2012, PloS one.

[29]  Young-Sook Kang,et al.  The Acetylcholinesterase Inhibitors Competitively Inhibited an Acetyl l-Carnitine Transport Through the Blood–Brain Barrier , 2012, Neurochemical Research.

[30]  M. Danhof,et al.  Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical setting. , 2011, Journal of pharmaceutical sciences.

[31]  C. Daumas-Duport,et al.  Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. , 2011, Molecular pharmaceutics.

[32]  R. Wennberg,et al.  Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by Bilirubin at the Blood-CSF and Blood-Brain Barriers in the Gunn Rat , 2011, PloS one.

[33]  Bengt R. Johansson,et al.  Pericytes regulate the blood–brain barrier , 2010, Nature.

[34]  B. Barres,et al.  Pericytes are required for blood–brain barrier integrity during embryogenesis , 2010, Nature.

[35]  Werner Weitschies,et al.  Commonly used nonionic surfactants interact differently with the human efflux transporters ABCB1 (p-glycoprotein) and ABCC2 (MRP2). , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[36]  W. Jahnen-Dechent,et al.  The Physiologic Development of Fetuin-A Serum Concentrations in Children , 2009, Pediatric Research.

[37]  J. Ghersi-Egea,et al.  Blood-brain interfaces and bilirubin-induced neurological diseases. , 2009, Current pharmaceutical design.

[38]  J. Ghersi-Egea,et al.  Differential expression of the multidrug resistance‐related proteins ABCb1 and ABCc1 between blood‐brain interfaces , 2008, The Journal of comparative neurology.

[39]  Thomas Brinker,et al.  Multiplicity of cerebrospinal fluid functions: New challenges in health and disease , 2008, Cerebrospinal Fluid Research.

[40]  Stina Syvänen,et al.  On The Rate and Extent of Drug Delivery to the Brain , 2007, Pharmaceutical Research.

[41]  D. Walker,et al.  Uteroplacental Inflammation Results in Blood Brain Barrier Breakdown, Increased Activated Caspase 3 and Lipid Peroxidation in the Late Gestation Ovine Fetal Cerebellum , 2007, Developmental Neuroscience.

[42]  H. Stolp,et al.  Functional effectiveness of the blood‐brain barrier to small water‐soluble molecules in developing and adult opossum (Monodelphis domestica) , 2006, The Journal of comparative neurology.

[43]  S. Rebello,et al.  Disposition of morphine in plasma and cerebrospinal fluid varies during neonatal development in pigs , 2005, The Journal of pharmacy and pharmacology.

[44]  H. Stolp,et al.  Breakdown of the blood–brain barrier to proteins in white matter of the developing brain following systemic inflammation , 2005, Cell and Tissue Research.

[45]  J. Ghersi-Egea,et al.  Detoxification systems, passive and specific transport for drugs at the blood-CSF barrier in normal and pathological situations. , 2004, Advanced drug delivery reviews.

[46]  W. Pardridge,et al.  Expression of the neonatal Fc receptor (FcRn) at the blood–brain barrier , 2002, Journal of neurochemistry.

[47]  L. Roncali,et al.  Immunogold cytochemistry of the blood-brain barrier glucose transporter GLUT1 and endogenous albumin in the developing human brain. , 2000, Brain research. Developmental brain research.

[48]  J. Ghersi-Egea,et al.  Choroid Plexus in the Central Nervous System: Biology and Physiopathology , 2000, Journal of neuropathology and experimental neurology.

[49]  G. Knott,et al.  Barriers in the Immature Brain , 2000, Cellular and Molecular Neurobiology.

[50]  L. Drewes,et al.  Monocarboxylate transporter (MCT1) abundance in brains of suckling and adult rats: a quantitative electron microscopic immunogold study. , 1999, Brain research. Developmental brain research.

[51]  H. Togari,et al.  Vulnerability to cerebral hypoxic-ischemic insult in neonatal but not in adult rats is in parallel with disruption of the blood-brain barrier. , 1997, Stroke.

[52]  P. Routledge,et al.  Drug-Induced Neurological Disorders , 1996, Drugs.

[53]  J. Ghersi-Egea,et al.  Rapid distribution of intraventricularly administered sucrose into cerebrospinal fluid cisterns via subarachnoid velae in rat , 1996, Neuroscience.

[54]  P. Knopf,et al.  Physiology and immunology of lymphatic drainage of interstitial and cerebrospinal fluid from the brain , 1995, Neuropathology and applied neurobiology.

[55]  C. Johanson,et al.  Postnatal developmental changes in blood flow to choroid plexuses and cerebral cortex of the rat. , 1994, The American journal of physiology.

[56]  A. Lehmenkühler,et al.  Extracellular space parameters in the rat neocortex and subcortical white matter during postnatal development determined by diffusion analysis , 1993, Neuroscience.

[57]  K Pettigrew,et al.  The Velocities of Red Cell and Plasma Flows through Parenchymal Microvessels of Rat Brain are Decreased by Pentobarbital , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[58]  B. Stonestreet,et al.  Blood-brain barrier integrity and brain water and electrolytes during hypoxia/hypercapnia and hypotension in newborn piglets , 1992, Brain Research.

[59]  A. Nehlig,et al.  Postnatal Changes in Local Cerebral Blood Flow Measured by the Quantitative Autoradiographic [14C]Iodoantipyrine Technique in Freely Moving Rats , 1989, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[60]  R. Deane,et al.  Developmental changes in cerebrospinal fluid pressure and resistance to absorption in rats. , 1987, Brain research.

[61]  K. Dziegielewska,et al.  Studies of the development of brain barrier systems to lipid insoluble molecules in fetal sheep. , 1979, The Journal of physiology.

[62]  P. Lundborg,et al.  Postnatal development of bulk flow in the cerebrospinal fluid system of the albino rat: clearance of carboxyl-( 14 C)inulin after intrathecal infusion. , 1973, Brain research.

[63]  M. Ehrnebo,et al.  Age differences in drug binding by plasma proteins: Studies on human foetuses, neonates and adults , 1971, European Journal of Clinical Pharmacology.

[64]  D. Maxwell,et al.  Development of the blood vessels and extracellular spaces during postnatal maturation of rat cerebral cortex , 1970, The Journal of comparative neurology.

[65]  R. Kauffman,et al.  The Need for Pediatric Drug Development. , 2018, The Journal of pediatrics.

[66]  Reflection paper on extrapolation of efficacy and safety in 3 paediatric medicine development 4 Draft 5 Draft agreed , 2016 .

[67]  Evidence of harm from off-label or unlicensed medicines in children , 2008 .

[68]  J. Stephenson Drug-Induced Neurological Disorders (2nd edn) , 2003 .

[69]  K. Dziegielewska,et al.  Development of the choroid plexus , 2001, Microscopy research and technique.

[70]  J. Fenstermacher Pharmacology of the Blood-Brain Barrier , 1989 .

[71]  E. Neuwelt,et al.  Implications of the Blood-Brain Barrier and Its Manipulation , 1989, Springer US.