Chasing genes in Alzheimer’s and Parkinson’s disease
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[1] J Carter,et al. Molecular Pathology of Alzheimer's Disease , 2013 .
[2] M. Brin,et al. Consensus Statement of the Movement Disorder Society on Tremor , 2008, Movement disorders : official journal of the Movement Disorder Society.
[3] W. Klunk,et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B , 2004, Annals of neurology.
[4] J. Noth,et al. DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease , 2004, Neurology.
[5] Patrizia Rizzu,et al. DJ‐1 colocalizes with tau inclusions: A link between parkinsonism and dementia , 2004, Annals of neurology.
[6] Eden R Martin,et al. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. , 2003, Human molecular genetics.
[7] S. Younkin,et al. Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. , 2003, Human molecular genetics.
[8] P. Rossini,et al. Atypical dementia associated with a novel presenilin‐2 mutation , 2003, Annals of neurology.
[9] F. LaFerla,et al. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer’s disease , 2003, Neurobiology of Aging.
[10] P. Lansbury,et al. Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. , 2003, Annual review of neuroscience.
[11] P. Lockhart,et al. RING finger 1 mutations in Parkin produce altered localization of the protein. , 2003, Human molecular genetics.
[12] Chankyu Park,et al. Crystal Structures of Human DJ-1 and Escherichia coli Hsp31, Which Share an Evolutionarily Conserved Domain* , 2003, Journal of Biological Chemistry.
[13] Sandro Sorbi,et al. Identification of new presenilin gene mutations in early-onset familial Alzheimer disease. , 2003, Archives of neurology.
[14] J. Gilbert,et al. Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22. , 2003, American journal of human genetics.
[15] C. V. van Duijn,et al. Suggestive linkage to chromosome 19 in a large Cuban family with late‐onset Parkinson's disease , 2003, Movement disorders : official journal of the Movement Disorder Society.
[16] M. Farrer,et al. Parkin variants in North American Parkinson's disease: Cases and controls , 2003, Movement disorders : official journal of the Movement Disorder Society.
[17] P. Heutink,et al. The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes. , 2003, Human molecular genetics.
[18] Janel O. Johnson,et al. α-Synuclein Locus Triplication Causes Parkinson's Disease , 2003, Science.
[19] J. Jankovic,et al. Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families. , 2003, Human molecular genetics.
[20] Daniel R. Scoles,et al. The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. , 2003, Human molecular genetics.
[21] J. Kemp,et al. PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation , 2003, The Journal of Neuroscience.
[22] D. Selkoe,et al. Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin* , 2003, Journal of Biological Chemistry.
[23] David W. Miller,et al. L166P Mutant DJ-1, Causative for Recessive Parkinson's Disease, Is Degraded through the Ubiquitin-Proteasome System* , 2003, Journal of Biological Chemistry.
[24] P. Pramstaller,et al. NR4A2 mutations are rare among European patients with familial Parkinson's disease , 2003, Annals of neurology.
[25] N. Quinn,et al. The role of pathogenic DJ‐1 mutations in Parkinson's disease , 2003, Annals of neurology.
[26] G. Higgins,et al. Transgenic mouse models of Alzheimer's disease: phenotype and application , 2003, Behavioural pharmacology.
[27] L. Mucke,et al. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[28] R. Nussbaum,et al. Functional analysis of intra-allelic variation at NACP-Rep1 in the α-synuclein gene , 2003, Human Genetics.
[29] Liang Tong,et al. Crystal Structure of Human DJ-1, a Protein Associated with Early Onset Parkinson's Disease* , 2003, Journal of Biological Chemistry.
[30] T. Niki,et al. The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease* , 2003, Journal of Biological Chemistry.
[31] H. Ke,et al. Crystal structure of DJ‐1/RS and implication on familial Parkinson's disease 1 , 2003, FEBS letters.
[32] Kenneth S. Kosik,et al. Apolipoprotein Eε4 modifies Alzheimer's disease onset in an E280A PS1 kindred , 2003 .
[33] Vincenzo Bonifati,et al. Early‐onset Parkinson's disease caused by a compound heterozygous DJ‐1 mutation , 2003, Annals of neurology.
[34] G. Petsko,et al. The 1.1-Å resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[35] G. Sedvall,et al. NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits , 2003, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[36] J. Growdon,et al. Age but Not Diagnosis Is the Main Predictor of Plasma Amyloid β-Protein Levels , 2003 .
[37] Thomas Gasser,et al. Point mutations in exon 1 of the NR4A2 gene are not a major cause of familial Parkinson′s disease , 2003, Neurogenetics.
[38] P. Lansbury,et al. Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease. , 2003, Biochemistry.
[39] Y. Agid,et al. Parkin mutations are frequent in patients with isolated early-onset parkinsonism. , 2003, Brain : a journal of neurology.
[40] Michael S. Wolfe,et al. γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[41] J. Trojanowski,et al. Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein , 2003, Science.
[42] A. Destée,et al. New parkin mutations and atypical phenotypes in families with autosomal recessive parkinsonism , 2003, Neurology.
[43] H. Cai,et al. Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals , 2003, The Journal of Neuroscience.
[44] L. Seeberger,et al. Significant linkage of Parkinson disease to chromosome 2q36-37. , 2003, American journal of human genetics.
[45] Isao Nishimura,et al. Parkin Suppresses Dopaminergic Neuron-Selective Neurotoxicity Induced by Pael-R in Drosophila , 2003, Neuron.
[46] T. Iwatsubo,et al. The role of presenilin cofactors in the γ-secretase complex , 2003, Nature.
[47] L. Seeberger,et al. Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease , 2003, Neurology.
[48] J. Karlawish,et al. Alzheimer Disease: Current Concepts and Emerging Diagnostic and Therapeutic Strategies , 2003, Annals of Internal Medicine.
[49] D. Aarsland,et al. Familial Parkinson's disease: a community‐based study , 2003, European journal of neurology.
[50] S. DeKosky,et al. Association of the 3′ UTR transcription factor LBP‐1c/CP2/LSF polymorphism with late‐onset Alzheimer's disease , 2003, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[51] L. Farrer,et al. Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community. , 2003, Human molecular genetics.
[52] P. Amouyel,et al. S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship , 2003, Movement disorders : official journal of the Movement Disorder Society.
[53] T. Dawson,et al. Rare genetic mutations shed light on the pathogenesis of Parkinson disease. , 2003, The Journal of clinical investigation.
[54] M. Cookson. Pathways to Parkinsonism , 2003, Neuron.
[55] M. Mouradian,et al. Parkin Accumulation in Aggresomes Due to Proteasome Impairment* , 2002, The Journal of Biological Chemistry.
[56] Patrik Brundin,et al. Pathogenesis of parkinson's disease: dopamine, vesicles and α-synuclein , 2002, Nature Reviews Neuroscience.
[57] Patrizia Rizzu,et al. Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism , 2002, Science.
[58] D. Selkoe. Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease. , 2002, The Journal of clinical investigation.
[59] Francis S. Collins,et al. Genomic medicine--a primer. , 2002, The New England journal of medicine.
[60] E. Tolosa,et al. Relative high frequency of the c.255delA parkin gene mutation in Spanish patients with autosomal recessive parkinsonism , 2002, Journal of neurology, neurosurgery, and psychiatry.
[61] Hreinn Stefánsson,et al. A susceptibility gene for late‐onset idiopathic Parkinson's disease , 2002, Annals of neurology.
[62] H. Klein,et al. Alzheimer's second patient: Johann F. and his family , 2002, Annals of neurology.
[63] David Altshuler,et al. Once and again-issues surrounding replication in genetic association studies. , 2002, The Journal of clinical endocrinology and metabolism.
[64] Nicola Pavese,et al. Progression of nigrostriatal dysfunction in a parkin kindred: an [18F]dopa PET and clinical study. , 2002, Brain : a journal of neurology.
[65] C. V. van Duijn,et al. A novel presenilin 1 mutation (L174 M) in a large Cuban family with early onset Alzheimer disease , 2002, Neurogenetics.
[66] H. Zoghbi,et al. Mouse and fly models of neurodegeneration. , 2002, Trends in genetics : TIG.
[67] D. Campion,et al. Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease , 2002, Neuroscience Letters.
[68] D. Selkoe,et al. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics , 2002, Science.
[69] Jean-François Deleuze,et al. Complex relationship between Parkin mutations and Parkinson disease. , 2002, American journal of medical genetics.
[70] T. Foroud,et al. Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations. , 2002, American journal of human genetics.
[71] Katrina A B Goddard,et al. A second locus for very-late-onset Alzheimer disease: a genome scan reveals linkage to 20p and epistasis between 20p and the amyloid precursor protein region. , 2002, American journal of human genetics.
[72] Ron Korstanje,et al. From QTL to gene: the harvest begins , 2002, Nature Genetics.
[73] M. Mattson,et al. Effects of cerebral ischemia in mice deficient in Persephin , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[74] L. Seeberger,et al. Linkage stratification and mutation analysis at the parkin locus identifies mutation positive Parkinson's disease families , 2002, Journal of medical genetics.
[75] Nancy A. Jenkins,et al. Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[76] D. Gudbjartsson,et al. A high-resolution recombination map of the human genome , 2002, Nature Genetics.
[77] S. Poduslo,et al. Lack of association of the two polymorphisms in alpha-2 macroglobulin with Alzheimer disease. , 2002, American journal of medical genetics.
[78] J. Trojanowski,et al. Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein , 2002, Neuron.
[79] J. Nutt,et al. Familial aggregation of Parkinson disease: a comparative study of early-onset and late-onset disease. , 2002, Archives of neurology.
[80] B. Strooper,et al. FAD mutant PS-1 gene-targeted mice: increased Aβ42 and Aβ deposition without APP overproduction , 2002, Neurobiology of Aging.
[81] M. MacDonald,et al. PARK3 influences age at onset in Parkinson disease: a genome scan in the GenePD study. , 2002, American journal of human genetics.
[82] J. Wilk,et al. Segregation analysis of Parkinson disease revealing evidence for a major causative gene. , 2002, American journal of medical genetics.
[83] Christine Klein,et al. Role of parkin mutations in 111 community‐based patients with early‐onset parkinsonism , 2002, Annals of neurology.
[84] R. Mohs,et al. Consortium to establish a registry for Alzheimer's disease (CERAD) clinical and neuropsychological assessment of Alzheimer's disease. , 2002, Psychopharmacology bulletin.
[85] J. Trojanowski,et al. Concurrence of α-synuclein and tau brain pathology in the Contursi kindred , 2002, Acta Neuropathologica.
[86] K. Marder,et al. Evaluation of 50 probands with early-onset Parkinson’s disease for Parkin mutations , 2002, Neurology.
[87] Rajesh Pahwa,et al. Age at onset in two common neurodegenerative diseases is genetically controlled. , 2002, American journal of human genetics.
[88] A. Fagan,et al. Human and Murine ApoE Markedly Alters Aβ Metabolism before and after Plaque Formation in a Mouse Model of Alzheimer's Disease , 2002, Neurobiology of Disease.
[89] P. Lansbury,et al. Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism. , 2002, Biochemistry.
[90] M. Owen,et al. Full genome screen for Alzheimer disease: stage II analysis. , 2002, American journal of medical genetics.
[91] J. Hirschhorn,et al. A comprehensive review of genetic association studies , 2002, Genetics in Medicine.
[92] S. Tsuji,et al. A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2–q13.1 , 2002, Annals of neurology.
[93] H. Vanderstichele,et al. Association of CSF apolipoprotein E, Aβ42 and cognition in Alzheimer’s disease , 2002, Neurobiology of Aging.
[94] M. Farrer,et al. A multi-incident, Old-Order Amish family with PD , 2002, Neurology.
[95] C. V. van Duijn,et al. Localization of autosomal recessive early‐onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset , 2002, Annals of neurology.
[96] M. Mouradian. Recent advances in the genetics and pathogenesis of Parkinson disease , 2002, Neurology.
[97] J. Growdon,et al. Epidemiologic study of 203 sibling pairs with Parkinson’s disease , 2002, Neurology.
[98] A. Bentivoglio,et al. Park6‐linked parkinsonism occurs in several european families , 2002, Annals of neurology.
[99] R. Nussbaum,et al. Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system. , 2001, Human molecular genetics.
[100] N. Pedersen,et al. Multiple-threshold models for genetic influences on age of onset for Alzheimer disease: findings in Swedish twins. , 2001, American journal of medical genetics.
[101] B. Crain,et al. Ectopic White Matter Neurons, a Developmental Abnormality That May Be Caused by the PSEN1 S169L Mutation in a Case of Familial AD with Myoclonus and Seizures , 2001, Journal of neuropathology and experimental neurology.
[102] M. Cruts,et al. Cerebral amyloid angiopathy is a pathogenic lesion in Alzheimer's disease due to a novel presenilin 1 mutation. , 2001, Brain : a journal of neurology.
[103] J. Haines,et al. Complete genomic screen in Parkinson disease: evidence for multiple genes. , 2001, JAMA.
[104] D. Easton,et al. Genome-wide linkage disequilibrium mapping of late-onset Alzheimer’s disease in Finland , 2001, Neurology.
[105] R. J. Dolan,et al. A novel presenilin mutation (M233V) causing very early onset Alzheimer's disease with Lewy bodies , 2001, Neuroscience Letters.
[106] V. Álvarez,et al. Early-onset Parkinson’s disease associated with a new parkin mutation in a Spanish family , 2001, Neuroscience Letters.
[107] A. Bentivoglio,et al. Phenotypic characterisation of autosomal recessive PARK6‐linked parkinsonism in three unrelated Italian families , 2001, Movement disorders : official journal of the Movement Disorder Society.
[108] T. Dawson,et al. The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders , 2001, Trends in Neurosciences.
[109] L. Palmer,et al. Genomewide scans of complex human diseases: true linkage is hard to find. , 2001, American journal of human genetics.
[110] M. Knyazeva,et al. Functional activation of microgyric visual cortex in a human , 2001, Annals of neurology.
[111] A J Lees,et al. What features improve the accuracy of clinical diagnosis in Parkinson's disease: A clinicopathologic study , 2001, Neurology.
[112] Mathew W. Wright,et al. The HUGO Gene Nomenclature Committee (HGNC) , 2001, Human Genetics.
[113] Andrew J. Lees,et al. Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease , 2001, Neurology.
[114] M. Owen,et al. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease , 2001, Human Genetics.
[115] C. van Broeckhoven,et al. Systematic genetic study of Alzheimer disease in Latin America: mutation frequencies of the amyloid beta precursor protein and presenilin genes in Colombia. , 2001, American journal of medical genetics.
[116] K. Goddard,et al. The amyloid precursor protein locus and very-late-onset Alzheimer disease. , 2001, American journal of human genetics.
[117] C. Woods,et al. Kufor-Rakeb syndrome, pallido-pyramidal degeneration with supranuclear upgaze paresis and dementia, maps to 1p36 , 2001, Journal of medical genetics.
[118] C. Ross,et al. Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease , 2001, Nature Medicine.
[119] Makoto Hashimoto,et al. β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[120] M. MacDonald,et al. Genome-wide scan for Parkinson's disease , 2001, Neurology.
[121] D. Hernandez,et al. Lewy bodies and parkinsonism in families with parkin mutations , 2001, Annals of neurology.
[122] J. Houwing-Duistermaat,et al. Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36. , 2001, American journal of human genetics.
[123] M. Mareel,et al. αT-Catenin: a novel tissue-specific β-catenin-binding protein mediating strong cell-cell adhesion , 2001 .
[124] D. Dickson,et al. Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP , 2001, Science.
[125] Matthew J. Farrer,et al. α-synuclein gene haplotypes are associated with Parkinson’s disease , 2001 .
[126] G. Savettieri,et al. Lack of association between ubiquitin carboxy-terminal hydrolase L1 gene polymorphism and PD , 2001, Neurology.
[127] A. Lang,et al. The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism. , 2001, Human molecular genetics.
[128] R. Mahley,et al. Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[129] G. Zubenko,et al. D10S1423 identifies a susceptibility locus for Alzheimer's disease in a prospective, longitudinal, double-blind study of asymptomatic individuals , 2001, Molecular Psychiatry.
[130] N. Hattori,et al. An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin , 2001, Cell.
[131] Nobutaka Hattori,et al. Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease , 2001, Science.
[132] M N Rossor,et al. Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype , 2001, Neurology.
[133] N. Hattori,et al. Parkin is linked to the ubiquitin pathway , 2001, Journal of Molecular Medicine.
[134] S. Blumen,et al. Parkin gene causing benign autosomal recessive juvenile parkinsonism , 2001, Neurology.
[135] Y. Agid,et al. Use of haplotype information to test involvement of the LRP gene in Alzheimer's disease in the French population , 2001, European Journal of Human Genetics.
[136] P. Chapman,et al. Genes, models and Alzheimer's disease. , 2001, Trends in genetics : TIG.
[137] D. Easton,et al. Genetic association of anLBP-1c/CP2/LSFgene polymorphism with late onset Alzheimer's disease , 2001, Journal of medical genetics.
[138] A. Bentivoglio,et al. Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36. , 2001, American journal of human genetics.
[139] K. Majamaa,et al. Hearing impairment in patients with 3243A→G mtDNA mutation: phenotype and rate of progression , 2001, Human Genetics.
[140] M. Farrer,et al. Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from Founder effects. , 2001, American journal of human genetics.
[141] K. Majamaa,et al. Complex segregation analysis of Parkinson's disease in the Finnish population , 2001, Human Genetics.
[142] W D Heiss,et al. Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial Parkinsonism associated with mutations in the Parkin gene , 2001, Annals of neurology.
[143] N. Quinn,et al. Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations , 2001, Neurology.
[144] C. Mariani,et al. New mutation (R42P) of the parkin gene in the ubiquitinlike domain associated with parkinsonism , 2001, Neurology.
[145] G. Bedoya,et al. A novel Cys212Tyr founder mutation in parkin and allelic heterogeneity of juvenile Parkinsonism in a population from North West Colombia , 2001, Neuroscience Letters.
[146] E. Tolosa,et al. Familial atypical progressive supranuclear palsy associated with homozigosity for the delN296 mutation in the tau gene , 2001, Annals of neurology.
[147] A. Iwamatsu,et al. Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat , 2001, Free radical research.
[148] A. Mitsumoto,et al. DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin , 2001, Free radical research.
[149] M G McInnis,et al. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. , 2000, Science.
[150] M. Owen,et al. Susceptibility locus for Alzheimer's disease on chromosome 10. , 2000, Science.
[151] J. Blangero,et al. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. , 2000, Science.
[152] A A Hicks,et al. Familial aggregation of Parkinson's disease in Iceland. , 2000, The New England journal of medicine.
[153] N M Laird,et al. Family-based tests of association in the presence of linkage. , 2000, American journal of human genetics.
[154] P. M. Conneally,et al. Identification of Novel Genes in Late-Onset Alzheimer's Disease , 2000, Experimental Gerontology.
[155] T. Dawson,et al. Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[156] L. Defebvre,et al. Linkage exclusion in French families with probable Parkinson's disease , 2000, Movement disorders : official journal of the Movement Disorder Society.
[157] D. Clair,et al. The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease. , 2000, Human molecular genetics.
[158] A. Hofman,et al. The α2-macroglobulin gene in AD , 2000, Neurology.
[159] Ruedi Aebersold,et al. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing , 2000, Nature.
[160] Hitoshi Takahashi,et al. An autopsy case of autosomal‐recessive juvenile parkinsonism with a homozygous exon 4 deletion in the parkin gene , 2000, Movement disorders : official journal of the Movement Disorder Society.
[161] F. Jessen,et al. Allelic association between the D10S1423 marker and Alzheimer's disease in a German population , 2000, Neuroscience Letters.
[162] K. Davis,et al. Contribution of Lewy body inclusions to dementia in patients with and without Alzheimer disease neuropathological conditions. , 2000, Archives of neurology.
[163] S. Tsuji,et al. Novel mutations, pseudo‐dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism , 2000, Annals of neurology.
[164] E. Tolosa,et al. A new mutation in the parkin gene in a patient with atypical autosomal recessive juvenile parkinsonism , 2000, Neuroscience Letters.
[165] J. Trojanowski,et al. Neuropathology of synuclein aggregates , 2000, Journal of neuroscience research.
[166] M. Polymeropoulos,et al. Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients , 2000, Neuroreport.
[167] K. Davis,et al. Has familial aggregation in Alzheimer's disease been overestimated? , 2000, International journal of geriatric psychiatry.
[168] Shinsei Minoshima,et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase , 2000, Nature Genetics.
[169] X. Breakefield,et al. Parkin deletions in a family with adult‐onset, tremor‐dominant parkinsonism: Expanding the phenotype , 2000, Annals of neurology.
[170] R. Hamilton,et al. Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using α‐Synuclein Immunohistochemistry , 2000, Brain pathology.
[171] N. Risch. Searching for genetic determinants in the new millennium , 2000, Nature.
[172] Bonifati,et al. Association between early-onset Parkinson's disease and mutations in the parkin gene. , 2000, The New England journal of medicine.
[173] R. Nitsch,et al. Variable expression of familial Alzheimer disease associated with presenilin 2 mutation M239I , 2000, Neurology.
[174] Nick C Fox,et al. Alzheimer's disease due to an intronic presenilin-1 (PSEN1 intron 4) mutation: A clinicopathological study. , 2000, Brain : a journal of neurology.
[175] P. Schofield,et al. Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene , 2000 .
[176] W. Kamphorst,et al. Coexistent tau and amyloid pathology in hereditary frontotemporal dementia with tau mutations , 2000, Neurobiology of Aging.
[177] C A Ross,et al. Synphilin‐1 is present in Lewy bodies in Parkinson's disease , 2000, Annals of neurology.
[178] R. Blesa,et al. A novel presenilin 1 mutation (Leu166Arg) associated with early-onset Alzheimer disease. , 2000, Archives of neurology.
[179] W. Bender,et al. A Drosophila model of Parkinson's disease , 2000, Nature.
[180] A. Fagan,et al. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[181] J. Haines,et al. Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity. , 2000, American journal of human genetics.
[182] M. Tabaton,et al. Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy , 2000, Annals of neurology.
[183] L. Mucke,et al. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. , 2000, Science.
[184] Heidi Phillips,et al. Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System , 2000, Neuron.
[185] G. Belle,et al. Cholinergic dysfunction in diseases with Lewy bodies , 2000, Neurology.
[186] Mario Pirastu,et al. Population choice in mapping genes for complex diseases , 1999, Nature Genetics.
[187] M. Farrer,et al. Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson’s disease , 1999, Neurology.
[188] Takayuki Harada,et al. Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice , 1999, Nature Genetics.
[189] B. Dubois,et al. Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum. , 1999, American journal of human genetics.
[190] M. Polymeropoulos,et al. Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding alpha-synuclein. , 1999, American journal of human genetics.
[191] Nicholas W. Wood,et al. The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease , 1999, Neuroscience Letters.
[192] B. Yankner,et al. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[193] M G Spillantini,et al. Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau. , 1999, Journal of neuropathology and experimental neurology.
[194] C. Tzourio,et al. Familial aggregation of Parkinson’s disease , 1999, Neurology.
[195] N. Cairns,et al. α-2 macroglobulin polymorphism and Alzheimer disease risk in the UK , 1999, Nature Genetics.
[196] Paola Piccini,et al. The role of inheritance in sporadic Parkinson's disease: Evidence from a longitudinal study of dopaminergic function in twins , 1999, Annals of neurology.
[197] R. Krüger,et al. Increased susceptibility to sporadic Parkinson's disease by a certain combined α‐synuclein/apolipoprotein E genotype , 1999, Annals of neurology.
[198] J. Haines,et al. An α-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease , 1999, Nature Genetics.
[199] S. Minoshima,et al. Polymorphism in the parkin gene in sporadic Parkinson's disease , 1999, Annals of neurology.
[200] D. Selkoe,et al. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity , 1999, Nature.
[201] Y. Agid,et al. A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease. , 1999, Human molecular genetics.
[202] I Litvan,et al. Association of an extended haplotype in the tau gene with progressive supranuclear palsy. , 1999, Human molecular genetics.
[203] William J. Ray,et al. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain , 1999, Nature.
[204] M. Owen,et al. No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease , 1999, Neuroscience Letters.
[205] M. Farrer,et al. Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease. , 1999, Neuroreport.
[206] M. Owen,et al. A full genome scan for late onset Alzheimer's disease , 1999 .
[207] G. Hadjigeorgiou,et al. Mutated α-synuclein gene in two Greek kindreds with familial PD: Incomplete penetrance? , 1999, Neurology.
[208] J W Langston,et al. Parkinson disease in twins: an etiologic study. , 1999, JAMA.
[209] T. Taylor,et al. Segregation analysis of Parkinson disease. , 1998, American journal of medical genetics.
[210] N. Shimizu,et al. Molecular genetic analysis of a novel Parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: Evidence for variable homozygous deletions in the Parkin gene in affected individuals , 1998, Annals of neurology.
[211] Peter T. Lansbury,et al. Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease , 1998, Nature Medicine.
[212] M. Albert,et al. Genetic association of an (α2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease , 1998 .
[213] Hans Clevers,et al. Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis , 1998, Nature.
[214] Georg Auburger,et al. The ubiquitin pathway in Parkinson's disease , 1998, Nature.
[215] P. Worley,et al. Homer Regulates the Association of Group 1 Metabotropic Glutamate Receptors with Multivalent Complexes of Homer-Related, Synaptic Proteins , 1998, Neuron.
[216] Hitoshi Takahashi,et al. Clinical and neuropathological aspects of autosomal recessive juvenile parkinsonism , 1998, Journal of Neurology.
[217] T. Kondo,et al. Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q , 1998, Neurology.
[218] D. Perl,et al. Alzheimer's disease and parkinson's disease: Distinct entities or extremes of a spectrum of neurodegeneration? , 1998, Annals of neurology.
[219] M. Owen,et al. Genetic studies on chromosome 12 in late-onset Alzheimer disease. , 1998, JAMA.
[220] A. Paterson,et al. Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity. , 1998, JAMA.
[221] Steven M. Horvath,et al. Alpha-2 macroglobulin is genetically associated with Alzheimer disease , 1998, Nature Genetics.
[222] C. Marsden,et al. The α‐synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: A study of 230 European cases , 1998 .
[223] Ronald C. Petersen,et al. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 , 1998, Nature.
[224] G. Zubenko,et al. A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution. , 1998, Genomics.
[225] B. Winblad,et al. Genetiska faktorer ligger ofta bakom Alzheimers sjukdom : Stor tvillingstudie skall klarlägga sambanden arv-miljö , 1998 .
[226] S. Minoshima,et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism , 1998, Nature.
[227] A. Paetau,et al. A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1 , 1998, Nature Medicine.
[228] C. Tanner,et al. Absence of mutations in the coding region of the α-synuclein gene in pathologically proven Parkinson's disease , 1998, Neurology.
[229] M. Smidt,et al. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[230] B. Müller-Myhsok,et al. A susceptibility locus for Parkinson's disease maps to chromosome 2p13 , 1998, Nature Genetics.
[231] M. Farrer,et al. Low frequency of α‐synuclein mutations in familial Parkinson's disease , 1998, Annals of neurology.
[232] J. Meyer,et al. Multiple threshold model for the onset of Alzheimer's disease in the NAS-NRC twin panel. , 1998, American journal of medical genetics.
[233] Olaf Riess,et al. AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease , 1998, Nature Genetics.
[234] Hugo Vanderstichele,et al. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein , 1998, Nature.
[235] J. Haines,et al. Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. , 1997, JAMA.
[236] E. Tolosa,et al. Identification of Spanish familial Parkinson's disease and screening for the Ala53Thr mutation of the α-synuclein gene in early onset patients , 1997, Neuroscience Letters.
[237] L. Thal,et al. Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), and apolipoprotein E receptor, with late-onset Alzheimer's disease , 1997, Neurology.
[238] Robert L. Nussbaum,et al. Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease , 1997 .
[239] B J Hoffer,et al. Dopamine neuron agenesis in Nurr1-deficient mice. , 1997, Science.
[240] T. Iwatsubo,et al. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[241] K Johansson,et al. Heritability for Alzheimer's disease: the study of dementia in Swedish twins. , 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.
[242] S. Tsuji,et al. The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta 42(43) , 1997, Neurology.
[243] K. Engedal,et al. The role of heredity in late-onset Alzheimer disease and vascular dementia. A twin study. , 1997, Archives of general psychiatry.
[244] A A Schäffer,et al. Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27. , 1997, American journal of human genetics.
[245] Miguel Ángel Martínez,et al. Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex. , 1997, American journal of human genetics.
[246] J. Dartigues,et al. Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease. , 1997, Journal of neurology, neurosurgery, and psychiatry.
[247] M. Polymeropoulos,et al. Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23 , 1996, Science.
[248] L. Golbe,et al. Clinical genetic analysis of Parkinson's disease in the contursi kindred , 1996, Annals of neurology.
[249] D. Borchelt,et al. Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo , 1996, Neuron.
[250] G. Schellenberg,et al. Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease , 1996, Nature Medicine.
[251] K. Marder,et al. Risk of Parkinson's disease among first-degree relatives , 1996, Neurology.
[252] J. Kaprio,et al. Alzheimer's disease in Finnish twins , 1996, The Lancet.
[253] J. Growdon,et al. Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study , 1996, Neurology.
[254] D. Galasko,et al. Neocortical Lewy Body Counts Correlate with Dementia in the Lewy Body Variant of Alzheimer's Disease , 1996, Journal of neuropathology and experimental neurology.
[255] E. Lander,et al. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results , 1995, Nature Genetics.
[256] G. Meco,et al. Familial Parkinson’s Disease: A Clinical Genetic Analysis , 1995, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.
[257] J. Rommens,et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene , 1995, Nature.
[258] G. Schellenberg,et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus , 1995, Science.
[259] E M Wijsman,et al. A familial Alzheimer's disease locus on chromosome 1 , 1995, Science.
[260] M. Folstein,et al. Alzheimer's disease in the National Academy of Sciences-National Research Council Registry of Aging Twin Veterans. III. Detection of cases, longitudinal results, and observations on twin concordance. , 1995, Archives of neurology.
[261] S. Sorbi,et al. Epistatic effect of APP717 mutation and apolipoprotein E genotype in familial Alzheimer's disease , 1995, Annals of neurology.
[262] D. Pollen,et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease , 1995, Nature.
[263] H. Przuntek,et al. Increased Risk of Parkinson's Disease in Relatives of Patients , 1995, Annals of neurology.
[264] J. Jankovic,et al. Tremor and longevity in relatives of patients with Parkinson's disease, essential tremor, and control subjects , 1995, Neurology.
[265] J. Nutt,et al. Increased risk of Parkinson's disease in parents and siblings of patients , 1994, Annals of neurology.
[266] A. M. Saunders,et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease , 1994, Nature Genetics.
[267] S. Younkin,et al. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. , 1994, Science.
[268] A. Mubaidin,et al. Pallido‐pyramidal degeneration, supranuclear upgaze paresis and dementia: Kufor‐Rakeb syndrome , 1994, Acta neurologica Scandinavica.
[269] M. Rossor,et al. Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region. , 1994, Human molecular genetics.
[270] J. Haines,et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.
[271] A. Hofman,et al. Genetic transmission of Alzheimer's disease among families in a Dutch population based study. , 1993, Journal of medical genetics.
[272] Michael Alford,et al. Differing patterns of aberrant neuronal sprouting in Alzheimer's disease with and without Lewy bodies , 1993, Brain Research.
[273] D. Dickson,et al. Pathology and Biology of the Lewy Body , 1993, Journal of neuropathology and experimental neurology.
[274] B. Winblad,et al. Risk factors for late‐ onset Alzheimer's disease: A population‐ based, case‐control study , 1993, Annals of neurology.
[275] A. Lees,et al. A clinicopathologic study of 100 cases of Parkinson's disease. , 1993, Archives of neurology.
[276] D. Selkoe,et al. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production , 1992, Nature.
[277] C. Broeckhoven,et al. Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3 , 1992, Nature Genetics.
[278] D. Pollen,et al. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14 , 1992, Nature Genetics.
[279] J. Weber,et al. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. , 1992, Science.
[280] J. Haines,et al. Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. , 1992, American journal of human genetics.
[281] J. Ott,et al. Strategies for characterizing highly polymorphic markers in human gene mapping. , 1992, American journal of human genetics.
[282] B. Winblad,et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid , 1992, Nature Genetics.
[283] J. Hardy,et al. Alzheimer's disease: the amyloid cascade hypothesis. , 1992, Science.
[284] J. Hardy,et al. Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene , 1991, Nature.
[285] B. Ghetti,et al. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. , 1991, Science.
[286] A. Hofman,et al. Frequency and distribution of Alzheimer's disease in Europe: A collaborative study of 1980–1990 prevalence findings , 1991, Annals of neurology.
[287] M. Pericak-Vance,et al. Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. , 1991, American journal of human genetics.
[288] J. Growdon,et al. Segregation analysis reveals evidence of a major gene for Alzheimer disease. , 1991, American journal of human genetics.
[289] S. M. Sumi,et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) , 1991, Neurology.
[290] M. Pericak-Vance,et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.
[291] A. Hofman,et al. Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case-control studies. , 1991, International journal of epidemiology.
[292] J. Lowe,et al. Ubiquitin carboxyl‐terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases , 1990, The Journal of pathology.
[293] C. Clark,et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) , 1990, Neurology.
[294] Douglas C. Miller,et al. A large kindred with autosomal dominant Parkinson's disease , 1990, Annals of neurology.
[295] A. Hofman,et al. History of dementia and Parkinson's disease in 1st‐degree relatives of patients with Alzheimer's disease , 1989, Neurology.
[296] M. Albert,et al. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. , 1989, JAMA.
[297] K D Wilkinson,et al. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. , 1989, Science.
[298] J. Ott. Computer-simulation methods in human linkage analysis. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[299] J. Growdon,et al. Assessment of genetic risk for alzheimer's disease among first‐degree relatives , 1989, Annals of neurology.
[300] J. Kaprio,et al. Parkinson's disease in a nationwide twin cohort , 1988, Neurology.
[301] A. Chakravarti,et al. Risk of dementia in relatives of patients with Alzheimer's disease , 1988, Neurology.
[302] Shirley A. Miller,et al. A simple salting out procedure for extracting DNA from human nucleated cells. , 1988, Nucleic acids research.
[303] K. Davis,et al. Familial aggregation in Alzheimer's disease , 1988, Neurology.
[304] K. Davis,et al. Alzheimer's disease. Morbid risk among first-degree relatives approximates 50% by 90 years of age. , 1987, Archives of general psychiatry.
[305] D. Pollen,et al. The genetic defect causing familial Alzheimer's disease maps on chromosome 21. , 1987, Science.
[306] R. Mayeux,et al. Heterogeneity in dementia of the Alzheimer type , 1985, Neurology.
[307] P. Mölsä,et al. Extrapyramidal signs in Alzheimer's disease , 1984, Neurology.
[308] G. Lathrop,et al. Easy calculations of lod scores and genetic risks on small computers. , 1984, American journal of human genetics.
[309] C. Ward,et al. Parkinson's disease in 65 pairs of twins and in a set of quadruplets , 1983, Neurology.
[310] B. Keats,et al. Alzheimer disease: evidence for susceptibility loci on chromosomes 6 and 14. , 1983, American journal of human genetics.
[311] U. Roessmann,et al. Parkinson disease, dementia, and alzheimer disease: Clinicopathological correlations , 1980, Annals of neurology.
[312] S. Folstein,et al. “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician , 1975 .
[313] O. Hill. A Twin Study , 1968, British Journal of Psychiatry.
[314] Bertram Müller-Myhsok,et al. The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval. , 2004, American journal of human genetics.
[315] O. Varenne,et al. A call for accurate phenotype definition in the study of complex disorders , 2004, Nature Genetics.
[316] Hong Jiang,et al. Mutations in NR4A2 associated with familial Parkinson disease , 2003, Nature Genetics.
[317] M. Albert,et al. Results of a high-resolution genome screen of 437 Alzheimer's disease families. , 2003, Human molecular genetics.
[318] G. Schellenberg,et al. Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-ε4 Allele , 2003 .
[319] T. Iwatsubo,et al. The role of presenilin cofactors in the gamma-secretase complex. , 2003, Nature.
[320] Xuebing Cao,et al. Point mutation in the parkin gene on patients with Parkinson's disease. , 2003, Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
[321] A. Singleton,et al. alpha-Synuclein locus triplication causes Parkinson's disease. , 2003, Science.
[322] J. H. Lee,et al. Chromosome-12 mapping of late-onset Alzheimer disease among Caribbean Hispanics. , 2002, American journal of human genetics.
[323] G. Small,et al. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. , 2002, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
[324] M. Owen,et al. No association of polymorphisms in the chat locus with late-onset Alzheimer's disease , 2002 .
[325] M. Farrer,et al. Two large British kindreds with familial Parkinson's disease: a clinico-pathological and genetic study. , 2002, Brain : a journal of neurology.
[326] A. Dehejia,et al. Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element. , 2001, Genome research.
[327] 志村 秀樹. Familial Parkinson disase gene product,parkin,is a ubiquitin-protein ligase , 2001 .
[328] E M Wijsman,et al. The number of trait loci in late-onset Alzheimer disease. , 2000, American journal of human genetics.
[329] K. Marder,et al. Familial aggregation of Alzheimer disease among whites, African Americans, and Caribbean Hispanics in northern Manhattan. , 2000, Archives of neurology.
[330] R. Nitsch,et al. High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes. , 2000, American journal of human genetics.
[331] H. Wiśniewski,et al. Plasma and cerebrospinal fluid Levels of amyloid β proteins 1-40 and 1-42 in Alzheimer disease , 2000 .
[332] P. Schofield,et al. Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene: expansion of the disease phenotype caused by tau gene mutations. , 2000, Brain : a journal of neurology.
[333] M. Farrer,et al. A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor. , 1999, Human molecular genetics.
[334] S. P. Fodor,et al. High density synthetic oligonucleotide arrays , 1999, Nature Genetics.
[335] J. Haines,et al. An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease. , 1999, Nature genetics.
[336] S. Chakraverty,et al. No association between the alpha-2 macroglobulin I 1000 V polymorphism and Alzheimer ’ s disease , 1999 .
[337] M. Owen,et al. Alpha-2 macroglobulin gene and Alzheimer disease. , 1999, Nature genetics.
[338] J. Haines,et al. No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease , 1998, Neurogenetics.
[339] A Hofman,et al. Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. , 1998, Human molecular genetics.
[340] J. Hardy,et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes , 1998, Nature Medicine.
[341] D. Price,et al. Mutant genes in familial Alzheimer's disease and transgenic models. , 1998, Annual review of neuroscience.
[342] A. Brookes,et al. Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene. , 1998, Biochemical and biophysical research communications.
[343] J. Kaprio,et al. Alzheimer's disease in twins. , 1997, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[344] P. Lantos,et al. Pathology of familial Alzheimer's disease with Lewy bodies. , 1997, Journal of neural transmission. Supplementum.
[345] Weiming Xia,et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice , 1997, Nature Medicine.
[346] S E Ide,et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. , 1997, Science.
[347] M G Spillantini,et al. Alpha-synuclein in Lewy bodies. , 1997, Nature.
[348] S. Hodge,et al. Twin studies and the genetics of Parkinson's disease—a reappraisal , 1990, Movement disorders : official journal of the Movement Disorder Society.
[349] A. Alzheimer. Uber eine eigenartige Erkrankung der Hirnrinde , 1907 .