Fomivirsen - a phosphorothioate oligonucleotide for the treatment of CMV retinitis.
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[1] D. Ecker,et al. Combinatorially selected guanosine-quartet structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusion. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[2] A. Krieg,et al. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides. , 1996, Journal of immunology.
[3] W. H. Barr,et al. A pharmacokinetic evaluation of 14C‐labeled afovirsen sodium in patients with genital warts , 1994, Clinical pharmacology and therapeutics.
[4] Y. Cheng,et al. Inhibition of herpes simplex virus type 2 growth by phosphorothioate oligodeoxynucleotides , 1990, Antimicrobial Agents and Chemotherapy.
[5] A. Zutshi,et al. Pharmacokinetics of a potential human cytomegalovirus therapeutic, a phosphorothioate oligonucleotide, after intravitreal injection in the rabbit. , 1997, Drug metabolism and disposition: the biological fate of chemicals.
[6] Y. Cheng,et al. Effect of phosphorothioate homo-oligodeoxynucleotides on herpes simplex virus type 2-induced DNA polymerase. , 1989, The Journal of biological chemistry.
[7] Matthew T. Davis,et al. A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS. , 1991, Annals of internal medicine.
[8] C. F. Bennett,et al. Progress in antisense oligonucleotide therapeutics. , 1996, Annual review of pharmacology and toxicology.
[9] S. Yamamoto,et al. Ability of oligonucleotides with certain palindromes to induce interferon production and augment natural killer cell activity is associated with their base length. , 1994, Antisense research and development.
[10] C. Katlama,et al. Efficacy and tolerance of intravitreal ganciclovir in cytomegalovirus retinitis in acquired immune deficiency syndrome. , 1991, Ophthalmology.
[11] S. Crooke. Progress in antisense therapeutics discovery and development. , 1997, Ciba Foundation symposium.
[12] G. Bishop,et al. CpG motifs in bacterial DNA trigger direct B-cell activation , 1995, Nature.
[13] Discovering antisense reagents by hybridization of RNA to oligonucleotide arrays. , 1997, Ciba Foundation symposium.
[14] R. Crooke,et al. Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region , 1993, Antimicrobial Agents and Chemotherapy.
[15] S. Crooke,et al. Effect of antisense oligonucleotides on cytokine release from human keratinocytes in an in vitro model of skin. , 1996, Toxicology and applied pharmacology.
[16] T. Merigan,et al. Interferon Induction Increased through Chemical Modification of a Synthetic Polyribonucleotide , 1969, Science.
[17] P. D. Cook,et al. Antisense medicinal chemistry , 1998 .
[18] G. Hartmann,et al. Oligodeoxynucleotides Enhance Lipopolysaccharide-Stimulated Synthesis of Tumor Necrosis Factor: Dependence on Phosphorothioate Modification and Reversal by Heparin , 1996, Molecular medicine.
[19] K U Mir,et al. Arrays of complementary oligonucleotides for analysing the hybridisation behaviour of nucleic acids. , 1994, Nucleic acids research.
[20] A. Levin,et al. Pharmacokinetics of an antisense oligonucleotide injected intravitreally in monkeys. , 1998, Drug metabolism and disposition: the biological fate of chemicals.
[21] A. Levin,et al. Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a 4-week study in CD-1 mice. , 1997, Antisense & nucleic acid drug development.
[22] Immune Stimulation by Oligonucleotides , 1998 .
[23] J. P. Shea,et al. Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats. , 1993, The Journal of pharmacology and experimental therapeutics.
[24] S. Beaucage,et al. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[25] D. Kornbrust,et al. Comparison of the toxicity profiles of ISIS 1082 and ISIS 2105, phosphorothioate oligonucleotides, following subacute intradermal administration in Sprague-Dawley rats. , 1997, Toxicology.
[26] R. Buckheit,et al. Antiviral activity of a phosphorothioate oligonucleotide complementary to human cytomegalovirus RNA when used in combination with antiviral nucleoside analogs. , 1995, Antiviral research.
[27] D. Hume,et al. Macrophages ingest and are activated by bacterial DNA. , 1996, Journal of immunology.
[28] M. Stephenson,et al. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. , 1978, Proceedings of the National Academy of Sciences of the United States of America.