Role of LRRTMs in synapse development and plasticity

[1]  Y. Bae,et al.  SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3–LAR adhesion , 2016, Nature Communications.

[2]  J. Cloutier,et al.  Slitrk1 is localized to excitatory synapses and promotes their development , 2016, Scientific Reports.

[3]  Daniel J. Whitcomb,et al.  SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development , 2016, Scientific Reports.

[4]  P. Scheiffele,et al.  Control of neuronal synapse specification by a highly dedicated alternative splicing program , 2016, Science.

[5]  W. Heo,et al.  Neurotrophin-3 Regulates Synapse Development by Modulating TrkC-PTPσ Synaptic Adhesion and Intracellular Signaling Pathways , 2016, The Journal of Neuroscience.

[6]  C. Robinson,et al.  Super-complexes of adhesion GPCRs and neural guidance receptors , 2016, Nature Communications.

[7]  T. Kajander,et al.  Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding. , 2016, Biochemistry.

[8]  Seung-Hee Lee,et al.  LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding. , 2016, Cell reports.

[9]  A. Craig,et al.  Neurotrophin-3 Enhances the Synaptic Organizing Function of TrkC–Protein Tyrosine Phosphatase σ in Rat Hippocampal Neurons , 2015, The Journal of Neuroscience.

[10]  T. Südhof,et al.  Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. , 2015, Structure.

[11]  Y. Bae,et al.  Splicing-Dependent Trans-synaptic SALM3–LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion , 2015, Cell reports.

[12]  R. Nicoll,et al.  The cellular and molecular landscape of neuroligins , 2015, Trends in Neurosciences.

[13]  Y. Fujiyoshi,et al.  An intracellular domain with a novel sequence regulates cell surface expression and synaptic clustering of leucine‐rich repeat transmembrane proteins in hippocampal neurons , 2015, Journal of neurochemistry.

[14]  E. Castrén,et al.  Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling. , 2015, Developmental cell.

[15]  S. Fukai,et al.  Structure of Slitrk2–PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion , 2015, Scientific Reports.

[16]  D. Schreiner,et al.  Quantitative isoform-profiling of highly diversified recognition molecules , 2015, eLife.

[17]  R. Klein,et al.  Structural Basis of Latrophilin-FLRT Interaction , 2015, Structure.

[18]  K. Tabuchi,et al.  PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission , 2015, Proceedings of the National Academy of Sciences.

[19]  Jie-Oh Lee,et al.  Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion , 2014, Nature Communications.

[20]  Weixian Lu,et al.  Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis , 2014, Nature Communications.

[21]  R. Klein,et al.  FLRT Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development , 2014, Neuron.

[22]  N. Koch-Henriksen,et al.  Prediction of response to interferon therapy in multiple sclerosis , 2014, Acta neurologica Scandinavica.

[23]  Anirvan Ghosh,et al.  Control of neural circuit formation by leucine-rich repeat proteins , 2014, Trends in Neurosciences.

[24]  C. Francks,et al.  Hypomethylation of the paternally inherited LRRTM1 promoter linked to schizophrenia , 2014, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[25]  P. Limprasert,et al.  Mutation screening of the neurexin 1 gene in thai patients with intellectual disability and autism spectrum disorder. , 2014, Genetic testing and molecular biomarkers.

[26]  J. Imitola,et al.  Fraternal twins with autism, severe cognitive deficit, and epilepsy: diagnostic role of chromosomal microarray analysis. , 2014, Seminars in pediatric neurology.

[27]  Gratien G. Prefontaine,et al.  The imprinted gene LRRTM1 mediates schizotypy and handedness in a nonclinical population , 2014, Journal of Human Genetics.

[28]  T. Südhof,et al.  Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. , 2014, Cell reports.

[29]  T. Kajander,et al.  Origin and Loss of Nested LRRTM/α-Catenin Genes during Vertebrate Evolution , 2014, PloS one.

[30]  Robert C. Green,et al.  Genome-wide association study of the rate of cognitive decline in Alzheimer's disease , 2014, Alzheimer's & Dementia.

[31]  S. Itohara,et al.  Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses , 2013, Journal of Cell Science.

[32]  Steven A. Connor,et al.  The Specific α-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development , 2013, Neuron.

[33]  Ann Marie Craig,et al.  Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization , 2013, Trends in Neurosciences.

[34]  J. Yates,et al.  Unbiased Discovery of Glypican as a Receptor for LRRTM4 in Regulating Excitatory Synapse Development , 2013, Neuron.

[35]  Steven A. Connor,et al.  An LRRTM4-HSPG Complex Mediates Excitatory Synapse Development on Dentate Gyrus Granule Cells , 2013, Neuron.

[36]  T. Südhof,et al.  Leucine-Rich Repeat Transmembrane Proteins Are Essential for Maintenance of Long-Term Potentiation , 2013, Neuron.

[37]  Thomas C. Südhof,et al.  Presynaptic Neurexin-3 Alternative Splicing trans-Synaptically Controls Postsynaptic AMPA Receptor Trafficking , 2013, Cell.

[38]  V. Pankratz,et al.  LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer’s Disease (LOAD) , 2013, PloS one.

[39]  Hongyan Zhang,et al.  Association study of NRXN3 polymorphisms with schizophrenia and risperidone-induced bodyweight gain in Chinese Han population , 2013, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[40]  S. Strittmatter,et al.  LRRTM1-deficient mice show a rare phenotype of avoiding small enclosures—A tentative mouse model for claustrophobia-like behaviour , 2013, Behavioural Brain Research.

[41]  Eunjoon Kim,et al.  Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases , 2013, Proceedings of the National Academy of Sciences.

[42]  Lilia M. Iakoucheva,et al.  Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation , 2012, Cell.

[43]  G. Rappold,et al.  5q31 Microdeletions: Definition of a Critical Region and Analysis of LRRTM2, a Candidate Gene for Intellectual Disability , 2012, Molecular Syndromology.

[44]  J. Ko.  The leucine-rich repeat superfamily of synaptic adhesion molecules: LRRTMs and Slitrks , 2012, Molecules and cells.

[45]  R. Mayeux,et al.  Effect of genetic variation in LRRTM3 on risk of Alzheimer disease. , 2012, Archives of neurology.

[46]  Uwe Schulte,et al.  High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor Complexes , 2012, Neuron.

[47]  A. Ingason,et al.  Mutations in NRXN1 in a family multiply affected with brain disorders: NRXN1 mutations and brain disorders , 2012, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[48]  J. Yates,et al.  FLRT Proteins Are Endogenous Latrophilin Ligands and Regulate Excitatory Synapse Development , 2012, Neuron.

[49]  T. Tsumoto,et al.  Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction , 2012, Nature Neuroscience.

[50]  S. South,et al.  Chromosomal loss of 3q26.3‐3q26.32, involving a partial neuroligin 1 deletion, identified by genomic microarray in a child with microcephaly, seizure disorder, and severe intellectual disability , 2012, American journal of medical genetics. Part A.

[51]  Pamela B. Mahon,et al.  A genome-wide association study of attempted suicide , 2011, Molecular Psychiatry.

[52]  J. Sebat,et al.  High Frequencies of De Novo CNVs in Bipolar Disorder and Schizophrenia , 2011, Neuron.

[53]  L. Luo,et al.  Role of leucine-rich repeat proteins in the development and function of neural circuits. , 2011, Annual review of cell and developmental biology.

[54]  T. Südhof,et al.  The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo , 2011, Proceedings of the National Academy of Sciences.

[55]  Robert W. Williams,et al.  Genetic regulation of Nrnx1 expression: an integrative cross-species analysis of schizophrenia candidate genes , 2011, Translational Psychiatry.

[56]  T. Hashikawa,et al.  Impaired Cognitive Function and Altered Hippocampal Synapse Morphology in Mice Lacking Lrrtm1, a Gene Associated with Schizophrenia , 2011, PloS one.

[57]  T. Südhof,et al.  Jcb: Article , 2022 .

[58]  V. Tarabykin,et al.  FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons , 2011, Neuroscience Research.

[59]  Eunjoon Kim,et al.  The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules. , 2011, Seminars in cell & developmental biology.

[60]  Joris Vermeesch,et al.  A 10.46 Mb 12p11.1–12.1 interstitial deletion coincident with a 0.19 Mb NRXN1 deletion detected by array CGH in a girl with scoliosis and autism , 2011, American journal of medical genetics. Part A.

[61]  X. Chen,et al.  Genetic regulation of Nrnx1 expression: an integrative cross-species analysis of schizophrenia candidate genes , 2011, Translational Psychiatry.

[62]  Laurent Mottron,et al.  Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia , 2011, Human Genetics.

[63]  A. Craig,et al.  Synaptic organizing complexes , 2011, Current Opinion in Neurobiology.

[64]  T. Murphy,et al.  Postsynaptic TrkC and Presynaptic PTPσ Function as a Bidirectional Excitatory Synaptic Organizing Complex , 2011, Neuron.

[65]  S. Hauser,et al.  Aggregation of multiple sclerosis genetic risk variants in multiple and single case families , 2011, Annals of neurology.

[66]  A. Reymond,et al.  A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo , 2011, PLoS biology.

[67]  Dai Zhang,et al.  A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population , 2011, Behavioral and Brain Functions.

[68]  QingYun Mai,et al.  Dynamic expression patterns of imprinted genes in human embryonic stem cells following prolonged passaging and differentiation , 2011, Journal of Assisted Reproduction and Genetics.

[69]  A. Minelli,et al.  New Copy Number Variations in Schizophrenia , 2010, PloS one.

[70]  T. Karlsen,et al.  Association to the Glypican-5 gene in multiple sclerosis , 2010, Journal of Neuroimmunology.

[71]  Gary D Bader,et al.  Functional impact of global rare copy number variation in autism spectrum disorders , 2010, Nature.

[72]  Michael R. Johnson,et al.  A Genome-Wide Association Study of Neuroticism in a Population-Based Sample , 2010, PloS one.

[73]  P. Stankiewicz,et al.  Intragenic rearrangements in NRXN1 in three families with autism spectrum disorder, developmental delay, and speech delay , 2010, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[74]  Raika Pancaroglu,et al.  LRRTMs and Neuroligins Bind Neurexins with a Differential Code to Cooperate in Glutamate Synapse Development , 2010, The Journal of Neuroscience.

[75]  Eunjoon Kim,et al.  Selected SALM (Synaptic Adhesion-Like Molecule) Family Proteins Regulate Synapse Formation , 2010, The Journal of Neuroscience.

[76]  Yiping Shen,et al.  Deletions of NRXN1 (Neurexin-1) Predispose to a Wide Spectrum of Developmental Disorders , 2010, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[77]  A. Pagnamenta,et al.  Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry , 2010, Molecular autism.

[78]  Tomas Drgon,et al.  Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit Success Genotype Score Uncorrected Proof Materials and Methods Study Design Uncorrected Proof , 2022 .

[79]  Eunjoon Kim,et al.  Trans-synaptic Adhesions between Netrin-G Ligand-3 (NGL-3) and Receptor Tyrosine Phosphatases LAR, Protein-tyrosine Phosphatase δ (PTPδ), and PTPσ via Specific Domains Regulate Excitatory Synapse Formation* , 2010, The Journal of Biological Chemistry.

[80]  Thomas C. Südhof,et al.  LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation , 2009, Neuron.

[81]  J. Yates,et al.  LRRTM2 Interacts with Neurexin1 and Regulates Excitatory Synapse Formation , 2009, Neuron.

[82]  F. Calahorro,et al.  Osmotic avoidance in Caenorhabditis elegans: synaptic function of two genes, orthologues of human NRXN1 and NLGN1, as candidates for autism. , 2009, Journal of visualized experiments : JoVE.

[83]  T. Südhof,et al.  Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments , 2009, Proceedings of the National Academy of Sciences.

[84]  Eunjoon Kim,et al.  The NGL family of leucine-rich repeat-containing synaptic adhesion molecules , 2009, Molecular and Cellular Neuroscience.

[85]  S. Cichon,et al.  Supporting evidence for LRRTM1 imprinting effects in schizophrenia , 2009, Molecular Psychiatry.

[86]  M. Sheng,et al.  Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses , 2009, Nature Neuroscience.

[87]  M. Verbeek,et al.  Amyloid β induces cellular relocalization and production of agrin and glypican-1 , 2009, Brain Research.

[88]  S. Strittmatter,et al.  An Unbiased Expression Screen for Synaptogenic Proteins Identifies the LRRTM Protein Family as Synaptic Organizers , 2009, Neuron.

[89]  Elvira Bramon,et al.  Disruption of the neurexin 1 gene is associated with schizophrenia. , 2009, Human molecular genetics.

[90]  Michael R. Johnson,et al.  Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. , 2009, Human molecular genetics.

[91]  J. Kennedy,et al.  Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: A preliminary study , 2009, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[92]  C. Francks.  Understanding the genetics of behavioural and psychiatric traits will only be achieved through a realistic assessment of their complexity , 2009, Laterality.

[93]  Daniel Mathalon,et al.  A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. , 2009, Schizophrenia bulletin.

[94]  T. Südhof.  Neuroligins and neurexins link synaptic function to cognitive disease , 2008, Nature.

[95]  Susanne Walitza,et al.  Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies , 2008, Journal of Neural Transmission.

[96]  R. Wenthold,et al.  Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth , 2008, Molecular and Cellular Neuroscience.

[97]  Caryn Lerman,et al.  Molecular genetics of successful smoking cessation: convergent genome-wide association study results. , 2008, Archives of general psychiatry.

[98]  Ming D. Li,et al.  Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers. , 2008, Human molecular genetics.

[99]  Eden R Martin,et al.  Confronting complexity in late‐onset Alzheimer disease: application of two‐stage analysis approach addressing heterogeneity and epistasis , 2008, Genetic epidemiology.

[100]  R. Petralia,et al.  The SALM Family of Adhesion-like Molecules Forms Heteromeric and Homomeric Complexes* , 2008, Journal of Biological Chemistry.

[101]  G. Uhl,et al.  Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms. , 2007, Human molecular genetics.

[102]  Jacqueline Blundell,et al.  A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice , 2007, Science.

[103]  Eunjoon Kim,et al.  Leucine‐rich repeat proteins of synapses , 2007, Journal of neuroscience research.

[104]  D. Geschwind,et al.  LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia , 2007, Molecular Psychiatry.

[105]  Robert D. Finn,et al.  New developments in the InterPro database , 2007, Nucleic Acids Res..

[106]  P. Rigby,et al.  Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis. , 2007, Gene expression patterns : GEP.

[107]  P. Scheiffele,et al.  Mixed-culture assays for analyzing neuronal synapse formation , 2007, Nature Protocols.

[108]  Scott F. Saccone,et al.  Novel genes identified in a high-density genome wide association study for nicotine dependence. , 2007, Human molecular genetics.

[109]  James Wilhelm,et al.  The Structure of the Lingo-1 Ectodomain, a Module Implicated in Central Nervous System Repair Inhibition* , 2006, Journal of Biological Chemistry.

[110]  Shane D. Marine,et al.  LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease , 2006, Proceedings of the National Academy of Sciences.

[111]  T. Révész,et al.  Molecular chaperons, amyloid and preamyloid lesions in the BRI2 gene‐related dementias: a morphological study , 2006, Neuropathology and applied neurobiology.

[112]  R. Weinberg,et al.  NGL family PSD-95–interacting adhesion molecules regulate excitatory synapse formation , 2006, Nature Neuroscience.

[113]  B. Kaang,et al.  SALM Synaptic Cell Adhesion-like Molecules Regulate the Differentiation of Excitatory Synapses , 2006, Neuron.

[114]  A. Craig,et al.  Structure Function and Splice Site Analysis of the Synaptogenic Activity of the Neurexin-1β LNS Domain , 2006, The Journal of Neuroscience.

[115]  A. Craig,et al.  How to build a central synapse: clues from cell culture , 2006, Trends in Neurosciences.

[116]  A. Craig,et al.  Structure function and splice site analysis of the synaptogenic activity of the neurexin-1 beta LNS domain. , 2006, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[117]  Mariza de Andrade,et al.  High-resolution whole-genome association study of Parkinson disease. , 2005, American journal of human genetics.

[118]  Thomas C. Südhof,et al.  A Splice Code for trans-Synaptic Cell Adhesion Mediated by Binding of Neuroligin 1 to α- and β-Neurexins , 2005, Neuron.

[119]  T. Südhof,et al.  A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. , 2005, Neuron.

[120]  Ann Marie Craig,et al.  Neurexins Induce Differentiation of GABA and Glutamate Postsynaptic Specializations via Neuroligins , 2004, Cell.

[121]  T. Yamashita,et al.  FLRT3, a cell surface molecule containing LRR repeats and a FNIII domain, promotes neurite outgrowth. , 2004, Biochemical and Biophysical Research Communications - BBRC.

[122]  Masakatsu Kamiya,et al.  Structural principles of leucine‐rich repeat (LRR) proteins , 2003, Proteins.

[123]  W. Birchmeier,et al.  Role of β-Catenin in Synaptic Vesicle Localization and Presynaptic Assembly , 2003, Neuron.

[124]  K. Mikoshiba,et al.  Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth , 2003, Molecular and Cellular Neuroscience.

[125]  A. Fournier,et al.  Structure and axon outgrowth inhibitor binding of the Nogo‐66 receptor and related proteins , 2003, The EMBO journal.

[126]  M. Saarma,et al.  A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. , 2003, Genomics.

[127]  M. Sheng,et al.  PDZ Domains: Structural Modules for Protein Complex Assembly* , 2002, The Journal of Biological Chemistry.

[128]  M. Momoi,et al.  Association of autism in two patients with hereditary multiple exostoses caused by novel deletion mutations of EXT1 , 2002, Journal of Human Genetics.

[129]  B. Kobe,et al.  The leucine-rich repeat as a protein recognition motif. , 2001, Current opinion in structural biology.

[130]  R. Fetter,et al.  Neuroligin Expressed in Nonneuronal Cells Triggers Presynaptic Development in Contacting Axons , 2000, Cell.

[131]  L. Kunkel,et al.  Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. , 1999, Genomics.

[132]  T. Südhof,et al.  The Making of Neurexins , 1998, Journal of neurochemistry.

[133]  T. Südhof,et al.  Neurexins: three genes and 1001 products. , 1998, Trends in genetics : TIG.

[134]  J. S. Nelson,et al.  Fishes of the world. , 1978 .