Wearable Electrochemical Alcohol Biosensors.

The rapid development of wearable sensing platforms in recent years has led to an array of viable monitoring applications for various target analytes. As a significant biomarker with high impact in diverse areas, the reliable on-body detection and continuous monitoring of alcohol has become a focus of many such systems. Currently, several commercial sensing platforms are available that are capable of transdermal monitoring of alcohol consumption using insensible sweat. Drawbacks of existing alcohol sensing platforms that apply this sensing strategy have led to efforts in developing wearable biosensors capable of real-time alcohol detection in sampled biofluids such as sensible sweat and skin interstitial fluid. This review discusses the current trends in wearable electrochemical alcohol biosensing and highlights recent advances in such systems toward continuous, real-time monitoring of alcohol consumption. Our perspective on this important field is given with an outlook on the future of wearable electrochemical alcohol biosensors.

[1]  Sarah Kerrigan,et al.  Quantitative determination of caffeine and alcohol in energy drinks and the potential to produce positive transdermal alcohol concentrations in human subjects. , 2009, Journal of analytical toxicology.

[2]  G Simpson Accuracy and precision of breath-alcohol measurements for a random subject in the postabsorptive state. , 1987, Clinical chemistry.

[3]  J. Windmiller,et al.  Electrochemical tattoo biosensors for real-time noninvasive lactate monitoring in human perspiration. , 2013, Analytical chemistry.

[4]  Shalini Prasad,et al.  A wearable biochemical sensor for monitoring alcohol consumption lifestyle through Ethyl glucuronide (EtG) detection in human sweat , 2016, Scientific Reports.

[5]  Yuehe Lin,et al.  Low-potential stable NADH detection at carbon-nanotube-modified glassy carbon electrodes , 2002 .

[6]  Alan S Campbell,et al.  Wearable non-invasive epidermal glucose sensors: A review. , 2018, Talanta.

[7]  M. Buono,et al.  Sweat Ethanol Concentrations are Highly Correlated with Co‐Existing Blood Values in Humans , 1999, Experimental physiology.

[8]  D. Dougherty,et al.  Comparing the detection of transdermal and breath alcohol concentrations during periods of alcohol consumption ranging from moderate drinking to binge drinking. , 2012, Experimental and clinical psychopharmacology.

[9]  G A Marlatt,et al.  Verbal report methods in clinical research on alcoholism: response bias and its minimization. , 1987, Journal of studies on alcohol.

[10]  E. Nyman,et al.  The Elimination of Ethyl Alcohol in Sweat1 , 1936 .

[11]  Robert D. Brewer,et al.  Contribution of Excessive Alcohol Consumption to Deaths and Years of Potential Life Lost in the United States , 2014, Preventing chronic disease.

[12]  G D Christian,et al.  Voltammetric measurement of reduced nicotinamide-adenine nucleotides and application to amperometric measurement of enzyme reactions. , 1975, Analytica chimica acta.

[13]  Yuanyuan Liang,et al.  Time Delays in Transdermal Alcohol Concentrations Relative to Breath Alcohol Concentrations , 2017, Alcohol and alcoholism.

[14]  R. J. Long,et al.  Validity of transdermal alcohol monitoring: fixed and self-regulated dosing. , 2006, Alcoholism, clinical and experimental research.

[15]  Paul R Marques,et al.  Field and laboratory alcohol detection with 2 types of transdermal devices. , 2009, Alcoholism, clinical and experimental research.

[16]  Chwee Teck Lim,et al.  Emerging flexible and wearable physical sensing platforms for healthcare and biomedical applications , 2016, Microsystems & Nanoengineering.

[17]  Nancy P Barnett,et al.  A preliminary randomized controlled trial of contingency management for alcohol use reduction using a transdermal alcohol sensor , 2017, Addiction.

[18]  Nancy P Barnett,et al.  Experiences with SCRAMx alcohol monitoring technology in 100 alcohol treatment outpatients. , 2017, Drug and alcohol dependence.

[19]  Nancy P Barnett,et al.  Continuous objective monitoring of alcohol use: twenty-first century measurement using transdermal sensors. , 2013, Alcoholism, clinical and experimental research.

[20]  M. Bates,et al.  Immediate, quantitative estimation of blood alcohol concentration from saliva. , 1997, Journal of studies on alcohol.

[21]  Jack Darkes,et al.  The validity of self-reports of alcohol consumption: state of the science and challenges for research. , 2003, Addiction.

[22]  Jeesun Jung,et al.  Prevalence of 12-Month Alcohol Use, High-Risk Drinking, and DSM-IV Alcohol Use Disorder in the United States, 2001-2002 to 2012-2013: Results From the National Epidemiologic Survey on Alcohol and Related Conditions , 2017, JAMA psychiatry.

[23]  Robert D. Brewer,et al.  Prevalence of Alcohol Dependence Among US Adult Drinkers, 2009–2011 , 2014, Preventing chronic disease.

[24]  Pranab Goswami,et al.  Advances in developing rapid, reliable and portable detection systems for alcohol. , 2017, Biosensors & bioelectronics.

[25]  Joseph Wang,et al.  Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System , 2016 .

[26]  D. Cole,et al.  Use of a new sample-collection device (Macroduct) in anion analysis of human sweat. , 1986, Clinical chemistry.

[27]  Sam Emaminejad,et al.  Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform , 2017, Proceedings of the National Academy of Sciences.

[28]  J M Pingarrón,et al.  A novel non-invasive electrochemical biosensing device for in situ determination of the alcohol content in blood by monitoring ethanol in sweat. , 2014, Analytica chimica acta.

[29]  R. Pidva,et al.  Clinical Evaluation of a Novel Interstitial Fluid Sensor System for Remote Continuous Alcohol Monitoring , 2008, IEEE Sensors Journal.

[30]  R. Swift,et al.  Direct measurement of alcohol and its metabolites. , 2003, Addiction.

[31]  A. Laconti,et al.  Studies on a wearable, electronic, transdermal alcohol sensor. , 1992, Alcoholism, clinical and experimental research.

[32]  Rasa Pauliukaite,et al.  An improved biosensor for acetaldehyde determination using a bienzymatic strategy at poly(neutral red) modified carbon film electrodes. , 2007, Analytica chimica acta.

[33]  Peter Witucki,et al.  Common hand sanitizer may distort readings of breathalyzer tests in the absence of acute intoxication. , 2013, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[34]  J Heikenfeld,et al.  The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications. , 2015, Biomicrofluidics.

[35]  John P. Allen,et al.  Measuring Alcohol Consumption: Psychosocial and Biochemical Methods , 1992 .

[36]  H. Jägfeldt,et al.  Adsorption and electrochemical oxidation behaviour of NADH at a clean platinum electrode , 1980 .

[37]  Karl Cammann,et al.  Screen-printed biosensors using different alcohol oxidases , 2001 .

[38]  Joshua Ray Windmiller,et al.  Continuous minimally-invasive alcohol monitoring using microneedle sensor arrays. , 2017, Biosensors & bioelectronics.

[39]  C. Wang,et al.  Deconvolving an estimate of breath measured blood alcohol concentration from biosensor collected transdermal ethanol data , 2008, Appl. Math. Comput..

[40]  Joseph Wang,et al.  Wearable Electrochemical Sensors and Biosensors: A Review , 2013 .

[41]  C. B. Clark,et al.  The impact of non-concordant self-report of substance use in clinical trials research. , 2016, Addictive behaviors.

[42]  T M Worner,et al.  The accuracy of breath alcohol analysis using the breathalyzer. , 1985, Alcohol and alcoholism.

[43]  Alan S. Campbell,et al.  Epidermal Microfluidic Electrochemical Detection System: Enhanced Sweat Sampling and Metabolite Detection. , 2017, ACS sensors.

[44]  R E COOKE,et al.  A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis. , 1959, Pediatrics.

[45]  T von Woedtke,et al.  Clinical usefulness of the glucose concentration in the subcutaneous tissue--properties and pitfalls of electrochemical biosensors. , 1994, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[46]  R. Swift,et al.  Transdermal alcohol measurement for estimation of blood alcohol concentration. , 2000, Alcoholism, clinical and experimental research.

[47]  G G Guilbault,et al.  Amperometric determination of alcohols, aldehydes and carboxylic acids with an immobilized alcohol oxidase enzyme electrode. , 1975, Analytica chimica acta.

[48]  Amay J. Bandodkar,et al.  Wearable Chemical Sensors: Present Challenges and Future Prospects , 2016 .

[49]  Sam Emaminejad,et al.  Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis , 2016, Nature.

[50]  Brown Dj,et al.  The pharmacokinetics of alcohol excretion in human perspiration. , 1985 .

[51]  Ana M Azevedo,et al.  Ethanol biosensors based on alcohol oxidase. , 2005, Biosensors & bioelectronics.

[52]  L Tian,et al.  Wearable sensors: modalities, challenges, and prospects. , 2018, Lab on a chip.

[53]  Ali Javey,et al.  Wearable sweat sensors , 2018 .