Retention and relearning of spatial delayed alternation in rats after ablation of the prefrontal or total non-prefrontal isocortex

In the present study we addressed the question whether, within the isocortex, the prefrontal area of the rat is uniquely involved in mediation of delayed alternation. In one group of rats the dorsolateral isocortex, from the dorsomedial shoulder to the dorsal lip of the rhinal sulcus was removed bilaterally in a single surgical session. In these rats delayed alternation in a T-maze was significantly less impaired than in rats with one stage bilateral removal of the medial prefrontal cortex. The prefrontal cortex seems not to depend crucially on isocortical input for its medication of delayed alternation.

[1]  B. Kolb,et al.  Behavioural and anatomical studies of the posterior parietal cortex in the rat , 1987, Behavioural Brain Research.

[2]  J. Kessler,et al.  Delayed-alternation performance after kainic acid lesions of the thalamic mediodorsal nucleus and the ventral tegmental area in the rat , 1981, Behavioural Brain Research.

[3]  C. Jacobsen.  FUNCTIONS OF FRONTAL ASSOCIATION AREA IN PRIMATES , 1935 .

[4]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[5]  D. Pandya,et al.  Architecture and Connections of the Frontal Lobe , 2019, The Frontal Lobes Revisited.

[6]  D. Pandya,et al.  Association areas of the cerebral cortex , 1982, Trends in Neurosciences.

[7]  P. Goldman-Rakic,et al.  Posterior parietal cortex in rhesus monkey: II. Evidence for segregated corticocortical networks linking sensory and limbic areas with the frontal lobe , 1989, The Journal of comparative neurology.

[8]  S. Siegel,et al.  Nonparametric Statistics for the Behavioral Sciences , 2022, The SAGE Encyclopedia of Research Design.

[9]  I. Divac,et al.  Sequential behavior after modified prefrontallesions in the rat , 1984 .

[10]  I. Divac,et al.  Synaptic proteins in frontal and control brain regions of rats after exposure to spatial problems , 1982, Behavioural Brain Research.

[11]  I. Divac,et al.  Retention and relearning of spatial delayed alternation in rats after combined or sequential lesions of the prefrontal and parietal cortex. , 1993, Acta neurobiologiae experimentalis.

[12]  I. Whishaw,et al.  Tongue protrusion mediated by spared anterior ventrolateral neocortex in neonatally decorticate rats: behavioral support for the neurogenetic hypothesis , 1989, Behavioural Brain Research.