Cationic carriers of genetic material and cell death: a mitochondrial tale.

[1]  G. López-Castejón,et al.  Nanoparticles can cause DNA damage across a cellular barrier. , 2009, Nature nanotechnology.

[2]  L. Naldini A Comeback for Gene Therapy , 2009, Science.

[3]  N. Copeland,et al.  Self-inactivating retroviral vector-mediated gene transfer induces oncogene activation and immortalization of primary murine bone marrow cells. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

[4]  H. Myung,et al.  Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction. , 2009, Toxicology letters.

[5]  R. Sharma,et al.  Missing pieces in understanding the intracellular trafficking of polycation/DNA complexes. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[6]  B. Zhivotovsky,et al.  DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis , 2009, Oncogene.

[7]  M. Tabrizian,et al.  Control of DNA incorporation into nanoparticles with poly(L-lysine) multilayers , 2008 .

[8]  G. Salvesen,et al.  Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues* , 2008, Journal of Biological Chemistry.

[9]  E. Wagner,et al.  Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity. , 2008, Bioconjugate chemistry.

[10]  R. Zhuo,et al.  Synthesis of (Dex-HMDI)-g-PEIs as effective and low cytotoxic nonviral gene vectors. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[11]  Yun-Jaie Choi,et al.  Highly efficient gene transfer with degradable poly(ester amine) based on poly(ethylene glycol) diacrylate and polyethylenimine in vitro and in vivo , 2008, The journal of gene medicine.

[12]  Leaf Huang,et al.  Non-viral is superior to viral gene delivery. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[13]  H. Uludaǧ,et al.  A comparative evaluation of poly-L-lysine-palmitic acid and Lipofectamine 2000 for plasmid delivery to bone marrow stromal cells. , 2007, Biomaterials.

[14]  Jianzhu Chen,et al.  Identification of Novel Superior Polycationic Vectors for Gene Delivery by High-throughput Synthesis and Screening of a Combinatorial Library , 2007, Pharmaceutical Research.

[15]  A. C. Hunter Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity. , 2006, Advanced drug delivery reviews.

[16]  S. McKenna,et al.  Evaluation of cellular uptake and gene transfer efficiency of pegylated poly-L-lysine compacted DNA: implications for cancer gene therapy. , 2006, Molecular pharmaceutics.

[17]  G. Salvesen,et al.  The apoptosome activates caspase-9 by dimerization. , 2006, Molecular cell.

[18]  Tomoko Nakamura,et al.  Cationic liposomes induce apoptosis through p38 MAP kinase–caspase‐8–Bid pathway in macrophage‐like RAW264.7 cells , 2006, Journal of leukocyte biology.

[19]  S Moein Moghimi,et al.  Low and high molecular weight poly(l‐lysine)s/poly(l‐lysine)–DNA complexes initiate mitochondrial‐mediated apoptosis differently , 2005, FEBS letters.

[20]  M. Monsigny,et al.  Potocytosis and cellular exit of complexes as cellular pathways for gene delivery by polycations , 2005, The journal of gene medicine.

[21]  P. van der Smissen,et al.  Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria. , 2005, Toxicology and applied pharmacology.

[22]  D. Fischer,et al.  Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives , 2005, The journal of gene medicine.

[23]  S Moein Moghimi,et al.  A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[24]  J. Martinou,et al.  Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer. , 2005, The Biochemical journal.

[25]  C. von Kalle,et al.  Clonal evidence for the transduction of CD34+ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial. , 2005, Blood.

[26]  J. Castro,et al.  Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[27]  B. Zhivotovsky,et al.  Caspase-2 Permeabilizes the Outer Mitochondrial Membrane and Disrupts the Binding of Cytochrome c to Anionic Phospholipids* , 2004, Journal of Biological Chemistry.

[28]  C. Giardina,et al.  Silica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[29]  S. Moghimi,et al.  Causative factors behind poloxamer 188 (Pluronic F68, Flocor)-induced complement activation in human sera. A protective role against poloxamer-mediated complement activation by elevated serum lipoprotein levels. , 2004, Biochimica et biophysica acta.

[30]  Mark H Ellisman,et al.  Disruption of Mitochondrial Function during Apoptosis Is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport Chain , 2004, Cell.

[31]  B. Zhivotovsky,et al.  Processed caspase‐2 can induce mitochondria‐mediated apoptosis independently of its enzymatic activity , 2004, EMBO reports.

[32]  A. Kichler Gene transfer with modified polyethylenimines , 2004, The journal of gene medicine.

[33]  S. Moghimi,et al.  Cellular Distribution of Nonionic Micelles , 2004, Science.

[34]  F. Szoka,et al.  Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes* , 2003, Journal of Biological Chemistry.

[35]  G. Krishnamoorthy,et al.  Intracellular dynamics of the gene delivery vehicle polyethylenimine during transfection: investigation by two-photon fluorescence correlation spectroscopy. , 2003, Biochimica et biophysica acta.

[36]  Cameron S. Osborne,et al.  LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1 , 2003, Science.

[37]  B. Antonsson,et al.  3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. , 2003, Journal of medicinal chemistry.

[38]  Hongzhe Sun,et al.  Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway , 2002, Pharmacological Reviews.

[39]  T. Niidome,et al.  Gene Therapy Progress and Prospects: Nonviral vectors , 2002, Gene Therapy.

[40]  S. Moghimi,et al.  Therapeutic synthetic polymers: a game of Russian roulette? , 2002, Drug discovery today.

[41]  Jindrich Kopecek,et al.  Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. , 2002, Advanced drug delivery reviews.

[42]  Gerrit Borchard,et al.  Transfection efficiency and toxicity of polyethylenimine in differentiated Calu-3 and nondifferentiated COS-1 cell cultures , 2002, AAPS PharmSci.

[43]  S. Korsmeyer,et al.  Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. , 2002, Cancer cell.

[44]  D. Fischer,et al.  Copolymers of ethylene imine and N-(2-hydroxyethyl)-ethylene imine as tools to study effects of polymer structure on physicochemical and biological properties of DNA complexes. , 2002, Bioconjugate chemistry.

[45]  D. W. Pack,et al.  On the kinetics of polyplex endocytic trafficking: implications for gene delivery vector design. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

[46]  G. Kroemer,et al.  Organelle-specific initiation of cell death pathways , 2001, Nature Cell Biology.

[47]  I. Enyedy,et al.  Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. , 2001, Journal of medicinal chemistry.

[48]  S M Moghimi,et al.  Long-circulating and target-specific nanoparticles: theory to practice. , 2001, Pharmacological reviews.

[49]  B. Zhivotovsky,et al.  Cytochrome c Release Occurs via Ca2+-dependent and Ca2+-independent Mechanisms That Are Regulated by Bax* , 2001, The Journal of Biological Chemistry.

[50]  Martin L Read,et al.  Systemic circulation of poly(L-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene therapy. , 2001, Blood.

[51]  D W Pack,et al.  Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[52]  G. Boivin,et al.  Adeno-associated virus mediates long-term gene transfer and delivery of chondroprotective IL-4 to murine synovium. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

[53]  Jay X. Tang,et al.  Hierarchical self-assembly of F-actin and cationic lipid complexes: stacked three-layer tubule networks. , 2000, Science.

[54]  F. Deist,et al.  Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. , 2000, Science.

[55]  Wei Li,et al.  Induction of cell death by the lysosomotropic detergent MSDH , 2000, FEBS letters.

[56]  D. Fischer,et al.  A Novel Non-Viral Vector for DNA Delivery Based on Low Molecular Weight, Branched Polyethylenimine: Effect of Molecular Weight on Transfection Efficiency and Cytotoxicity , 1999, Pharmaceutical Research.

[57]  G. Cohen,et al.  Redistribution of cytochrome c precedes the caspase-dependent formation of ultracondensed mitochondria, with a reduced inner membrane potential, in apoptotic monocytes. , 1999, The American journal of pathology.

[58]  C. Bortner,et al.  Caspase Independent/Dependent Regulation of K+, Cell Shrinkage, and Mitochondrial Membrane Potential during Lymphocyte Apoptosis* , 1999, The Journal of Biological Chemistry.

[59]  A. Mikos,et al.  Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[60]  A. R. Klemm,et al.  Effects of polyethyleneimine on endocytosis and lysosome stability. , 1998, Biochemical pharmacology.

[61]  K. Leong,et al.  DNA-polycation nanospheres as non-viral gene delivery vehicles. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[62]  M. Murphy,et al.  Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transition , 1997, FEBS letters.

[63]  I. Verma,et al.  Gene therapy - promises, problems and prospects , 1997, Nature.

[64]  V. Natarajan,et al.  Activation of endothelial cell phospholipase D by polycations. , 1997, The American journal of physiology.

[65]  Seamus J. Martin,et al.  Phosphatidylserine Externalization during CD95-induced Apoptosis of Cells and Cytoplasts Requires ICE/CED-3 Protease Activity* , 1996, The Journal of Biological Chemistry.

[66]  K. Mislick,et al.  Evidence for the role of proteoglycans in cation-mediated gene transfer. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[67]  F. Gage,et al.  In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector , 1996, Science.

[68]  D. Green,et al.  Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl , 1995, The Journal of experimental medicine.

[69]  D. Scherman,et al.  A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[70]  T. Hawley,et al.  Versatile retroviral vectors for potential use in gene therapy. , 1994, Gene therapy.

[71]  Xiao Xiao,et al.  Adeno-associated virus (AAV) vectors for gene transfer , 1993 .

[72]  R. Mulligan,et al.  The basic science of gene therapy. , 1993, Science.

[73]  K. Zatloukal,et al.  Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[74]  A. Miller,et al.  Human gene therapy comes of age , 1992, Nature.

[75]  D Needham,et al.  Elastic deformation and failure of lipid bilayer membranes containing cholesterol. , 1990, Biophysical journal.

[76]  C H Wu,et al.  Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. , 1987, The Journal of biological chemistry.

[77]  W. Shier,et al.  Polycations as prostaglandin synthesis inducers. Stimulation of arachidonic acid release and prostaglandin synthesis in cultured fibroblasts by poly(L-lysine) and other synthetic polycations. , 1984, Biochimica et biophysica acta.