Reduction, elimination, and levels: The case of the LTP-learning link

We argue in this paper that so-called new wave reductionism fails to capture the nature of the interlevel relations between psychology and neuroscience. Bickle (1995, Psychoneural reduction of the genuinely cognitive: some accomplished facts, Philosophical Psychology, 8, 265-285; 1998, Psychoneural reduction: the new wave, Cambridge, MA: MIT Press) has claimed that a (bottom-up) reduction of the psychological concepts of learning and memory to the concepts of neuroscience has in fact already been accomplished. An investigation of current research on the phenomenon of long-term potentiation reveals that this claim overstates the facts. Both the psychological and the neural concepts involved have not yet stabilized and face further correction under the influence of both bottom-up and top-down selection pressures. In addition, psychological concepts often refer to functions, and functions are indispensable and irreducible. Function ascriptions pick out objective patterns involving historical factors and dist...

[1]  T. Bliss,et al.  A synaptic model of memory: long-term potentiation in the hippocampus , 1993, Nature.

[2]  G. Lynch,et al.  Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5 , 1986, Nature.

[3]  Kenneth F. Schaffner,et al.  Approaches to Reduction , 1967, Philosophy of Science.

[4]  A. J. Silva,et al.  Gene targeting and the biology of learning and memory. , 1997, Annual review of genetics.

[5]  P. Milner,et al.  Preconceptions and prerequisites: Understanding the function of synaptic plasticity will also depend on a better systems-level understanding of the multiple types of memory , 1997, Behavioral and Brain Sciences.

[6]  Some Problems Concerning a Relational Concept of Mind , 1997 .

[7]  D. Cain LTP, NMDA, genes and learning , 1997, Current Opinion in Neurobiology.

[8]  R. Vance,et al.  Heroic Antireductionism and Genetics: A Tale of One Science , 1996, Philosophy of Science.

[9]  Karen Neander,et al.  The teleological notion of ‘function’ , 1991 .

[10]  Frank Jackson,et al.  Functionalism and broad content , 1988 .

[11]  Joseph E LeDoux The Emotional Brain: The Mysterious Underpinnings of Emotional Life , 1996 .

[12]  Robert A. Wilson Causal Depth, Theoretical Appropriateness, and Individualism in Psychology , 1994, Philosophy of Science.

[13]  F. Adams,et al.  Functions and Goal Directedness , 1992, Philosophy of Science.

[14]  M.K.D. Schouten,et al.  Defusing eliminativism: reference and revision , 1998 .

[15]  W. Wimsatt Reductionism, Levels of Organization, and the Mind-Body Problem , 1976 .

[16]  R. Nicoll,et al.  Contrasting properties of two forms of long-term potentiation in the hippocampus , 1995, Nature.

[17]  Philip Gasper,et al.  Reduction and Instrumentalism in Genetics , 1992, Philosophy of Science.

[18]  C. Barnes,et al.  Involvement of LTP in memory: Are we “searching under the street light”? , 1995, Neuron.

[19]  P. Churchland A Neurocomputational Perspective: The Nature of Mind and the Structure of Science , 1989 .

[20]  D. Cain Testing the NMDA, Long-term Potentiation, and Cholinergic Hypotheses of Spatial Learning , 1998, Neuroscience & Biobehavioral Reviews.

[21]  C. H. Vanderwolf,et al.  The behavioral neurobiology of learning and memory: A conceptual reorientation , 1994, Brain Research Reviews.

[22]  Cliff Hooker,et al.  Towards a General Theory of Reduction. Part I: Historical and Scientific Setting , 1981, Dialogue.

[23]  Robert N. McCauley Intertheoretic Relations and the Future of Psychology , 1986, Philosophy of Science.

[24]  T. Teyler,et al.  Long-term potentiation. , 1987, Annual review of neuroscience.

[25]  D. Cain,et al.  Spatial learning without NMDA receptor-dependent long-term potentiation , 1995, Nature.

[26]  Joseph E LeDoux,et al.  Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[27]  E. W. Kairiss,et al.  Long‐Term synaptic potentiation in the amygdala , 1990, Synapse.

[28]  Herbert Weingartner,et al.  Perspectives on Cognitive Neuroscience , 1991 .

[29]  P. Churchland Neurophilosophy: Toward a unified science of the mind , 1989 .

[30]  J. Bickle Psychoneural reduction of the genuinely cognitive: Some accomplished facts , 1995 .

[31]  R. Millikan In Defense of Proper Functions , 1989, Philosophy of Science.

[32]  R. Morris,et al.  Distinct components of spatial learning revealed by prior training and NMDA receptor blockade , 1995, Nature.

[33]  Christopher A. Shaw,et al.  An alternative to the LTP orthodoxy: a plasticity-pathology continuum model , 1996, Brain Research Reviews.

[34]  P. Pettit,et al.  Causation in the Philosophy of Mind , 1990 .

[35]  P Kitcher,et al.  1953 and all that: a tale of two sciences. , 1984, The Philosophical review.

[36]  Parallel Properties of Long-Term Potentiation and Memory , 1995 .

[37]  E. Kandel,et al.  Is there a cell-biological alphabet for simple forms of learning? , 1984 .

[38]  John Bickle,et al.  Psychoneural Reduction: The New Wave , 1998 .

[39]  Ronald Endicott Collapse of the New Wave , 1998 .

[40]  Valerie Gray Hardcastle How To Build A Theory In Cognitive Science , 1996 .

[41]  E. Kandel,et al.  Cognitive Neuroscience and the Study of Memory , 1998, Neuron.

[42]  Michael Davis,et al.  Beyond attention: The role of amygdala NMDA receptors in fear conditioning , 1997, Behavioral and Brain Sciences.

[43]  Huib Looren de Jong,et al.  Some Remarks on a Relational Concept of Mind , 1997 .

[44]  M. Alexander,et al.  Principles of Neural Science , 1981 .

[45]  Zenon W. Pylyshyn,et al.  Computation and Cognition: Toward a Foundation for Cognitive Science , 1984 .

[46]  E. Kandel,et al.  Essentials of Neural Science and Behavior , 1996 .

[47]  L. Nadel,et al.  The Hippocampus as a Cognitive Map , 1978 .

[48]  C. R. Gallistel Is Long-Term Potentiation a Plausible Basis for Memory? , 1995 .

[49]  S. L. Star,et al.  Regions of the Mind: Brain Research and the Quest for Scientific Certainty , 1989 .

[50]  Terrence J. Sejnowski,et al.  The Computational Brain , 1996, Artif. Intell..

[51]  Michael Davis,et al.  Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala , 1990, Nature.