Successful utilization of $$\upbeta $$β-ketonitrile in Biginelli reaction: synthesis of 5-cyanodihydropyrimidine

[1]  Arindam Mukhopadhyay,et al.  Biginelli reaction: an overview , 2016 .

[2]  H. Slimi,et al.  Synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via Biginelli reaction promoted by bismuth(III)nitrate or PPh3 without solvent , 2016 .

[3]  M. Kolosov,et al.  An effective Biginelli-type synthesis of 1-methoxy-3,4-dihydropyrimidin-2(1H)-ones , 2015 .

[4]  T. Shinada,et al.  Efficient total synthesis of manzacidin B , 2012 .

[5]  P. Souchay,et al.  Etude Spectroscopique De Quelques β‐Cyano‐Enamines Et Enamines N‐Substituees , 2010 .

[6]  R. Livingston,et al.  Development of a scaleable process for the synthesis of a next-generation statin , 2010 .

[7]  Yuta Suzuki,et al.  Direct catalytic asymmetric aldol reactions of thioamides: toward a stereocontrolled synthesis of 1,3-polyols. , 2009, Journal of the American Chemical Society.

[8]  J. Pandey,et al.  L-Proline catalyzed multicomponent reaction of 3,4-dihydro-(2H)-pyran, urea/thiourea, and aldehydes: diastereoselective synthesis of hexahydropyrano pyrimidinones (thiones) , 2009 .

[9]  M. Montazerozohori,et al.  An efficient and clean one‐pot synthesis of 3,4‐dihydropyrimidine‐2(1H)‐ones catalyzed by tungstate sulfuric acid in solvent‐free conditions , 2008 .

[10]  David K. Williams,et al.  One-pot two step synthesis of 5-cyano-dihydropyrimidinones using polyphosphate ester , 2008 .

[11]  J. Barrish,et al.  (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential. , 2008, Journal of medicinal chemistry.

[12]  C. Kappe,et al.  Multicomponent Cyclocondensations of b-Ketosulfones with Aldehydes and Aminoazole Building Blocks , 2007 .

[13]  A. Tolmachev,et al.  N-Substituted Ureas and Thioureas in Biginelli Reaction Promoted by Chlorotrimethylsilane: Convenient Synthesis of N1-Alkyl-, N1-Aryl-, and N1,N3-Dialkyl-3,4-Dihydropyrimidin-2(1H)-(thi)ones , 2007 .

[14]  James V. Vowles,et al.  A high-yielding preparation of beta-ketonitriles. , 2006, Organic letters.

[15]  Yijun Huang,et al.  Highly enantioselective Biginelli reaction using a new chiral ytterbium catalyst: asymmetric synthesis of dihydropyrimidines. , 2006, Journal of the American Chemical Society.

[16]  F. Buono,et al.  Oxidative dehydrogenation of dihydropyrimidinones and dihydropyrimidines. , 2005, Organic letters.

[17]  M. Lovrić,et al.  Ferric chloride/tetraethyl orthosilicate as an efficient system for synthesis of dihydropyrimidinones by Biginelli reaction , 2005 .

[18]  B. Karimi,et al.  N-Bromosuccinimide as an Almost Neutral Catalyst for Efficient Synthesis of Dihydropyrimidinones under Microwave Irradiation. , 2004 .

[19]  D. S. Bose,et al.  A Remarkable Rate Acceleration of the One-Pot Three-Component Cyclo­condensation Reaction at Room Temperature: An Expedient Synthesis of ­Mitotic Kinesin Eg5 Inhibitor Monastrol , 2004 .

[20]  C. Kappe,et al.  Solid- and solution-phase synthesis of bioactive dihydropyrimidines , 2004 .

[21]  D. Shi,et al.  One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using boric acid as catalyst , 2003 .

[22]  P. Kundu,et al.  One-pot synthesis of dihydropyrimidinones catalysed by lithium bromide: an improved procedure for the Biginelli reaction , 2003 .

[23]  C. Kappe,et al.  The Biginelli dihydropyrimidone synthesis using polyphosphate ester as a mild and efficient cyclocondensation/dehydration reagent , 2001 .

[24]  C. Kappe.  Biologically active dihydropyrimidones of the Biginelli-type--a literature survey. , 2000, European journal of medicinal chemistry.

[25]  C. Kappe.  Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog. , 2000, Accounts of chemical research.

[26]  McDonnell,et al.  A new substrate for the Biginelli cyclocondensation: direct preparation of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones from a beta-keto carboxylic acid , 2000, The Journal of organic chemistry.

[27]  C. Kappe,et al.  Synthesis and Reactions of Biginelli Compounds. Part 12. Polyphosphate Ester Mediated Synthesis of Dihydropyrimidines. Improved Conditions for the Biginelli Reaction. , 1998 .

[28]  C. Kappe,et al.  Polyphosphate Ester-Mediated Synthesis of Dihydropyrimidines. Improved Conditions for the Biginelli Reaction , 1998 .

[29]  E. Hu,et al.  Unprecedented Catalytic Three Component One-Pot Condensation Reaction: An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones , 1998 .

[30]  C. Kappe.  4-Aryldihydropyrimidines via the Biginelli Condensation: Aza-Analogs of Nifedipine-Type Calcium Channel Modulators , 1998 .

[31]  C. Kappe.  A Reexamination of the Mechanism of the Biginelli Dihydropyrimidine Synthesis. Support for an N-Acyliminium Ion Intermediate(1). , 1997, The Journal of organic chemistry.

[32]  G. Remennikov,et al.  Synthesis and some conversions of 6-methyl- and 1,6-dimethyl-5-nitro-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidines , 1993 .

[33]  C. Kappe,et al.  Synthesis and reactions of “biginelli‐compounds”. Part I , 1989 .

[34]  U. Krull,et al.  Studies on the keto-enol equilibria of methyl 2-oxocycloalkanoates with 5-8 carbons in the ring by IR, carbon-13 NMR, and mass spectrometry , 1988 .

[35]  G. Cerichelli,et al.  Substituent effects in keto-enol tautomerism. Part 3.1 influence of substitution on the equilibrium composition of of β-dicarbonyl compounds , 1988 .

[36]  J. Fissekis,et al.  Synthesis of 3,4-dihydro-2(1H)-pyrimidinones and the mechanism of the Biginelli reaction , 1973 .

[37]  M. T. Rogers,et al.  Keto—Enol Tautomerism in β-Dicarbonyls Studied by Nuclear Magnetic Resonance Spectroscopy. III. Studies of Proton Chemical Shifts and Equilibrium Constants at Different Temperatures1 , 1966 .