A computer-aided three-dimensional reconstruction of brain structures using high level computer graphics.

This paper describes how line drawings and continuous tone shaded images of a three-dimensional solid model of a brain structure are generated using a powerful general purpose computer graphics package. The model is built from a series of serial sections. We developed a software interface to convert the data entered by a section oriented way into a brain structure oriented file. We point out particularly the modular approach which consists of separating the tasks on small microcomputers or on bigger machines according to their computing cost. An example of a thalamic structure in a stereotaxic referential is presented.

[1]  Gary S. Watkins,et al.  A real time visible surface algorithm , 1970 .

[2]  R. Ranney Mize,et al.  A simple microcomputer-based three-dimensional serial section reconstruction system (MICROS) , 1983, Journal of Neuroscience Methods.

[3]  F. Bloom,et al.  Accurate three-dimensional reconstruction of neuronal distributions in brain: Reconstruction of the rat nucleus locus coeruleus , 1980, Journal of Neuroscience Methods.

[4]  C. Levinthal,et al.  Three-dimensional computer reconstruction of neurons and neuronal assemblies. , 1979, Annual review of biophysics and bioengineering.

[5]  J. Capowski,et al.  A system for the three-dimensional reconstruction of biological structures. , 1983, Computers and biomedical research, an international journal.

[6]  J. R. Augustine.  A lucite plate method for 3-dimensional reconstruction of neuronal populations , 1981, Journal of Neuroscience Methods.

[7]  P Suetens,et al.  Reconstruction of an arbitrary cross section from the serial drawings of a stereotaxic brain atlas. , 1980, Computer programs in biomedicine.

[8]  F. Afshar,et al.  A three-dimensional reconstruction of the human brain stem. , 1982, Journal of neurosurgery.

[9]  J C Mazziotta,et al.  Three-dimensional computer reconstruction and display of neuronal structure. , 1977, Computers in biology and medicine.

[10]  H. N. Christiansen,et al.  Movie.byu - 1981 , 1981, Eurographics.

[11]  Thomas W. Sederberg,et al.  Conversion of complex contour line definitions into polygonal element mosaics , 1978, SIGGRAPH.

[12]  C Levinthal,et al.  Special techniques for the automatic computer reconstruction of neuronal structures. , 1980, Annual Review of Biophysics and Bioengineering.

[13]  HENRI GOURAUD,et al.  Continuous Shading of Curved Surfaces , 1971, IEEE Transactions on Computers.

[14]  Edward P. Sayre,et al.  Computer-aided three-dimensional reconstruction and quantitative analysis of cells from serial electron microscopic montages of foetal monkey brain , 1974, Nature.

[15]  Randle W. Ware.  Three-dimensional reconstruction from serial sections. , 1975, International review of cytology.

[16]  R. L. Holmes.  Growth of the Nervous System , 1969 .

[17]  J J Capowski,et al.  Accurate computer reconstruction and graphics display of complex neurons utilizing state-of-the-art interactive techniques. , 1981, Computers and biomedical research, an international journal.

[18]  J. J. Capowski.  An automatic neuron reconstruction system , 1983, Journal of Neuroscience Methods.

[19]  Gribnau Aa,et al.  The preparation of graphical and three-dimensional reconstructions of the developing central nervous system. , 1976 .

[20]  Arthur H. Veen,et al.  TROTS: A computer graphics system for three-dimensional reconstruction from serial sections , 1977, Comput. Graph..

[21]  Edmund M. Glaser,et al.  The image-combining computer microscope — an interactive instrument for morphometry of the nervous system , 1983, Journal of Neuroscience Methods.

[22]  J Prothero,et al.  Three-dimensional reconstruction from serial sections. I. A portable microcomputer-based software package in fortran. , 1982, Computers and biomedical research, an international journal.

[23]  J R Augustine,et al.  Computer‐aided reconstructive morphology of the baboon abducens nucleus , 1985, The Anatomical record.

[24]  L D Cahan,et al.  Computer graphics--three dimensional reconstruction of thalamic anatomy from serial sections. , 1975, Computer programs in biomedicine.