Lösliche und virusgebundene Adenovirus Hämagglutinine

Prototype adenoviruses and their hemagglutinins of ROSEN'S 1 group II were studied by adsorption to rat and human red blood cells and by straight and cesium chloride density gradient ultracentrifugation. Density gradient experiments showed the presence of a hemagglutinin separable from the infectious virus particles which agglutinates both rat and human cells for virus types 9, 10, 13, 19, 26, and 27. In addition, types 10, 19, and 27 have a second hemagglutinin associated with the infective particles which agglutinates rat blood cells only. Type 9 (and possibly type 8) virus has a virusbound hemagglutinin which agglutinates both kinds of blood cells. The viruses types 15, 17, 22, and 24 with hemagglutinins for rat blood cells only have two hemagglutinins, one of them associated with the virus particles. The results with type 23 were variable. Straight ultracentrifugation experiments showed a surprisingly incomplete sedimentation of the infective particles for most of the virus types studied. Differences in the resistance of various hemagglutinins to trypsin and/or heating are demonstrated.