THE CLINICAL EVALUATION OF OVARIAN RESPONSES TO GONADOTROPIC THERAPY

OUR PRESENT concepts of endocrinopathic gynecology delineate the need for t erapeutic agents possessing an ability to alter qualitatively and quantitatively abnormalovarian functions. During the past decade there has been an increasing use of gonadotropic extracts in the treatment of various, presumably functional, aberrations of the endocrine system. For the most part these extracts have been prepared from pregnancy urine or placentae. These have been used, in most instances, for their supposed luteinizing effects. The last few years, however, have seen other sources explored in the quest for more effective gonadotropes; these have included the pituitaries of animals, the serum of pregnant mares and the urine of castrated and of postmenopausal women. These gonadotropes apparently possess more ability to induce follicle stimulation than those of the first group. Many conflicting reports dealing with the results of therapy with these various gonadotropes have appeared in the literature of recent years.