Assessment of Polymer-Polymer Interactions in Blends of HPMC and Film Forming Polymers by Modulated Temperature Differential Scanning Calorimetry

AbstractPurpose. To assess the miscibility and phase behavior of binary blendsof hydroxypropylmethyl cellulose (HPMC) with hydroxypropylcellulose (HPC), methylcellulose (MC), and polyvinylpyrrolidone (PVP). Methods. Polymer-polymer miscibility was assessed by measurementof the glass transition temperature (Tg) and the width of the glasstransition temperature (W-Tg), using modulated temperaturedifferential scanning calorimetry (MTDSC). Results. HPMC K4M/PVP and HPMC E5/MC blends were miscibleas evidenced by a single, composition dependent, Tg throughout theentire composition range. HPMC/HPC blends were immiscible at allcompositions. For the miscible blends, the variation in Tg with blendcomposition was compared to the values predicted by the Fox andCouchman-Karasz equations. At intermediate blend compositions,HPMC K4M/PVP blends exhibited negative deviations from idealbehavior. The Tg of the HPMC E5/MC blends was found to followthe Fox equation. The W-Tg measurements of the miscible blends gaveevidence of phase separation at certain compositions. Conclusions. MTDSC was shown to be a useful technique incharacterizing the interactions between some commonly used pharmaceuticalpolymers.

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