Calcium, contractions, and tropomyosin Focus on "divergent abnormal muscle relaxation by hypertrophic cardiomyopathy and nemaline myopathy mutant tropomyosins".

in skeletal and cardiac muscle, tropomyosin in association with troponin plays an essential role in Ca2+ regulation of the thin filament interaction with myosin that is responsible for contraction. Tropomyosin is an elongated coiled-coil α-helical dimer with 284 amino acids per peptide chain ([9][1

[1]  J. Metzger,et al.  Divergent abnormal muscle relaxation by hypertrophic cardiomyopathy and nemaline myopathy mutant tropomyosins. , 2002, Physiological genomics.

[2]  J. Tardiff,et al.  Cardiac troponin T mutations: correlation between the type of mutation and the nature of myofilament dysfunction in transgenic mice , 2001, The Journal of physiology.

[3]  F. Whitby,et al.  Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy. , 2001, Journal of molecular and cellular cardiology.

[4]  J. Seidman,et al.  The Genetic Basis for Cardiomyopathy from Mutation Identification to Mechanistic Paradigms , 2001, Cell.

[5]  Y. Maéda,et al.  Amino-acid replacements in an internal region of tropomyosin alter the properties of the entire molecule. , 2000, European journal of biochemistry.

[6]  J. Metzger,et al.  Direct, convergent hypersensitivity of calcium-activated force generation produced by hypertrophic cardiomyopathy mutant α-tropomyosins in adult cardiac myocytes , 1999, Nature Medicine.

[7]  J. Metzger,et al.  A nemaline myopathy mutation in alpha-tropomyosin causes defective regulation of striated muscle force production. , 1999, The Journal of clinical investigation.

[8]  T. Hewett,et al.  Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. , 1999, The Journal of clinical investigation.

[9]  J. Seidman,et al.  Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy. , 1998, The Journal of clinical investigation.

[10]  B. Maron,et al.  A mutant tropomyosin that causes hypertrophic cardiomyopathy is expressed in vivo and associated with an increased calcium sensitivity. , 1998, Circulation research.

[11]  Steven B Marston,et al.  Cardiac and skeletal myopathies: can genotype explain phenotype? , 2004, Journal of Muscle Research & Cell Motility.

[12]  S. Perry.  Vertebrate tropomyosin: distribution, properties and function , 2004, Journal of Muscle Research & Cell Motility.

[13]  N. Laing,et al.  A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy. , 1995, Nature genetics.