Hemokinin-1 and substance P stimulate production of inflammatory cytokines and chemokines in human colonic mucosa via both NK1 and NK2 tachykinin receptors

[1]  B. Gaszner,et al.  Hemokinin-1 is an important mediator of pain in mouse models of neuropathic and inflammatory mechanisms , 2019, Brain Research Bulletin.

[2]  Xinzhong Dong,et al.  A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain , 2019, Neuron.

[3]  E. Navratilova,et al.  Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously , 2019, Neuron.

[4]  Z. Helyes,et al.  Role of hemokinin-1 in health and disease , 2017, Neuropeptides.

[5]  Q. Guan,et al.  Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease , 2017, Mediators of inflammation.

[6]  F. Cominelli,et al.  Cytokines and intestinal inflammation , 2016, Current opinion in gastroenterology.

[7]  R. Dana,et al.  Neuropeptide substance P and the immune response , 2016, Cellular and Molecular Life Sciences.

[8]  P. Gascón,et al.  Biological and Pharmacological Aspects of the NK1-Receptor , 2015, BioMed research international.

[9]  E. Burcher,et al.  Inverse Expression of Prostaglandin E2-Related Enzymes Highlights Differences Between Diverticulitis and Inflammatory Bowel Disease , 2015, Digestive Diseases and Sciences.

[10]  J. Weinstock.  Substance P and the regulation of inflammation in infections and inflammatory bowel disease , 2015, Acta physiologica.

[11]  Markus F. Neurath,et al.  Cytokines in inflammatory bowel disease , 2014, Nature Reviews Immunology.

[12]  Shigeru Kobayashi,et al.  Hemokinin-1 competitively inhibits substance P-induced stimulation of osteoclast formation and function , 2013, Neuropeptides.

[13]  J. Stewart,et al.  Role of Tachykinin 1 and 4 Gene-Derived Neuropeptides and the Neurokinin 1 Receptor in Adjuvant-Induced Chronic Arthritis of the Mouse , 2013, PloS one.

[14]  T. Nishimori,et al.  New tachykinin peptides and nociception , 2013 .

[15]  T. Albert,et al.  Substance P Stimulates Production of Inflammatory Cytokines in Human Disc Cells , 2012, Spine.

[16]  Li Lin,et al.  Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor. , 2012, The international journal of biochemistry & cell biology.

[17]  R. Giannella,et al.  Th17 cells: interactions with predisposing factors in the immunopathogenesis of inflammatory bowel disease , 2012, Expert review of clinical immunology.

[18]  B. Southwell,et al.  Hemokinin-1 Stimulates Prostaglandin E2 Production in Human Colon through Activation of Cyclooxygenase-2 and Inhibition of 15-Hydroxyprostaglandin Dehydrogenase , 2012, Journal of Pharmacology and Experimental Therapeutics.

[19]  M. Neurath,et al.  Functional relevance of T helper 17 (Th17) cells and the IL‐17 cytokine family in inflammatory bowel disease , 2012, Inflammatory bowel diseases.

[20]  Kenji Nakamura,et al.  Quantification of chemokine and chemokine receptor gene expression in duodenal mucosa of dogs with inflammatory bowel disease. , 2011, Veterinary immunology and immunopathology.

[21]  Y. Daaka,et al.  PGE2 promotes angiogenesis through EP4 and PKA Cγ pathway. , 2011, Blood.

[22]  E. Burcher,et al.  Distinct differences in tachykinin gene expression in ulcerative colitis, Crohn’s disease and diverticular disease: a role for hemokinin‐1? , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[23]  Y. Delneste,et al.  The Tachykinins Substance P and Hemokinin-1 Favor the Generation of Human Memory Th17 Cells by Inducing IL-1β, IL-23, and TNF-Like 1A Expression by Monocytes , 2011, The Journal of Immunology.

[24]  A. Caraffa,et al.  Stimulation of CCL2 (MCP-1) and CCL2 mRNA by substance P in LAD2 human mast cells. , 2009, Translational research : the journal of laboratory and clinical medicine.

[25]  T. Klassert,et al.  Differential expression of neurokinin B and hemokinin-1 in human immune cells , 2008, Journal of Neuroimmunology.

[26]  R. Panettieri,et al.  Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[27]  T. Nishimori,et al.  Pharmacological characterization of desensitization in scratching behavior induced by intrathecal administration of hemokinin-1 in the rat , 2008, Neuropeptides.

[28]  M. Bhatia,et al.  Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils. , 2007, American journal of physiology. Cell physiology.

[29]  A. Mazar,et al.  Differential angiogenic regulation of experimental colitis. , 2006, The American journal of pathology.

[30]  C. Pothoulakis,et al.  Immunomodulatory Properties of Substance P , 2006, Annals of the New York Academy of Sciences.

[31]  G. Souza,et al.  CCL3/Macrophage inflammatory protein-1α induces fever and increases prostaglandin E2 in cerebrospinal fluid of rats: Effect of antipyretic drugs , 2006, Brain Research.

[32]  D. Binion,et al.  The Intestinal Microvasculature as a Therapeutic Target in Inflammatory Bowel Disease , 2006, Annals of the New York Academy of Sciences.

[33]  C. Pothoulakis,et al.  Substance P-Stimulated Interleukin-8 Expression in Human Colonic Epithelial Cells Involves Protein Kinase Cδ Activation , 2005, Journal of Pharmacology and Experimental Therapeutics.

[34]  A. Berger,et al.  Hemokinin-1 has Substance P-like function in U-251 MG astrocytoma cells: A pharmacological and functional study , 2005, Journal of Neuroimmunology.

[35]  M. Neurath,et al.  Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer , 2005, Clinical reviews in allergy & immunology.

[36]  D. Elliott,et al.  Cutting Edge: Hemokinin Has Substance P-Like Function and Expression in Inflammation1 , 2004, The Journal of Immunology.

[37]  K. Jeong,et al.  Regulation of Leukocyte Function-Associated Antigen 1-Mediated Adhesion by Somatostatin and Substance P in Mouse Spleen Cells , 2004, Neuroimmunomodulation.

[38]  C. Paige,et al.  T-cell developmental blockage by tachykinin antagonists and the role of hemokinin 1 in T lymphopoiesis. , 2003, Blood.

[39]  J. Steinke,et al.  2. Cytokines and chemokines. , 2003, The Journal of allergy and clinical immunology.

[40]  Penny A. Johnson,et al.  Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease , 2003, The Journal of pathology.

[41]  C. Pothoulakis,et al.  Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases. , 2002, The Biochemical journal.

[42]  B. Iizuka,et al.  Cytokine profile in colonic mucosa of ulcerative colitis correlates with disease activity and response to granulocytapheresis , 2002, American Journal of Gastroenterology.

[43]  W. Ho,et al.  Substance P up-regulates macrophage inflammatory protein-1β expression in human T lymphocytes , 2002, Journal of Neuroimmunology.

[44]  C. Austin,et al.  Identification, localization and receptor characterization of novel mammalian substance P-like peptides. , 2002, Gene.

[45]  E. Burcher,et al.  Roles of Substance P Receptors in Human Colon Circular Muscle: Alterations in Diverticular Disease , 2002, Journal of Pharmacology and Experimental Therapeutics.

[46]  U. Holzer‐Petsche,et al.  Tachykinin receptors in the gut: physiological and pathological implications. , 2001, Current opinion in pharmacology.

[47]  M. Leach,et al.  IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. , 2001, Immunity.

[48]  A. Koch,et al.  Chemokines and angiogenesis , 2001, Current opinion in rheumatology.

[49]  M. Leach,et al.  IL-4 Exacerbates Disease in a Th1 Cell Transfer Model of Colitis1 , 2001, The Journal of Immunology.

[50]  B. Fiebich,et al.  The Neuropeptide Substance P Activates p38 Mitogen-Activated Protein Kinase Resulting in IL-6 Expression Independently from NF-κB1 , 2000, The Journal of Immunology.

[51]  Gillian E. Wu,et al.  Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis , 2000, Nature Immunology.

[52]  F. Tonelli,et al.  Substance P (neurokinin-1) and neurokinin A (neurokinin-2) receptor gene and protein expression in the healthy and inflamed human intestine. , 2000, The American journal of pathology.

[53]  J. Ward,et al.  Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. , 2000, Blood.

[54]  K. Kataoka,et al.  Serial circulating concentrations of c‐reactive protein, interleukin (il)‐4, and il‐6 in patients with acute left heart decompensation , 1999, Clinical cardiology.

[55]  R. Macdermott.  Chemokines in the Inflammatory Bowel Diseases , 1999, Journal of Clinical Immunology.

[56]  M. Baggiolini,et al.  Short Communication Increased Expression of IP-10, IL-8, MCP-1, and MCP-3 in Ulcerative Colitis , 1999 .

[57]  G. Szegedi,et al.  [Angiotensin and its mediators. Their pathogenic and clinical significance in "angiogenic diseases"]. , 1998, Orvosi Hetilap.

[58]  W. Ho,et al.  Substance P augments interleukin-10 and tumor necrosis factor-α release by human cord blood monocytes and macrophages , 1996, Journal of Neuroimmunology.

[59]  P. Beart,et al.  Fishing for drugs from the sea: status and strategies. , 1995, Trends in pharmacological sciences.

[60]  J. Fauchère,et al.  Receptors and antagonists for substance P and related peptides. , 1994, Pharmacological reviews.

[61]  S. Guard,et al.  Stimulation of angiogenesis by substance P and interleukin‐1 in the rat and its inhibition by NK1 or interleukin‐1 receptor antagonists , 1993, British journal of pharmacology.