Full-field swept-source optical coherence tomography with phase-shifting techniques for skin cancer detection

The EU-funded project VIAMOS1 proposes an optical coherence tomography system (OCT) for skin cancer detection, which combines full-field and full-range swept-source OCT in a multi-channel sensor for parallel detection. One of the project objectives is the development of new fabrication technologies for micro-optics, which makes it compatible to Micro-Opto-Electromechanical System technology (MOEMS). The basic system concept is a wafer-based Mirau interferometer array with an actuated reference mirror, which enables phase shifted interferogram detection and therefore reconstruction of the complex phase information, resulting in a higher measurement range with reduced image artifacts. This paper presents an experimental one-channel on-bench OCT system with bulk optics, which serves as a proof-of-concept setup for the final VIAMOS micro-system. It is based on a Linnik interferometer with a wavelength tuning light source and a camera for parallel A-Scan detection. Phase shifting interferometry techniques (PSI) are used for the suppression of the complex conjugate artifact, whose suppression reaches 36 dB. The sensitivity of the system is constant over the full-field with a mean value of 97 dB. OCT images are presented of a thin membrane microlens and a biological tissue (onion) as a preliminary demonstration.

[1]  Peter Koch,et al.  In vivo Fourier-domain full-field OCT of the human retina with 1.5 million A-lines/s. , 2010, Optics letters.

[2]  J. Schuman,et al.  Optical coherence tomography. , 2000, Science.

[3]  A. Fercher,et al.  Phase-shifting algorithm to achieve high-speed long-depth-range probing by frequency-domain optical coherence tomography. , 2003, Optics letters.

[4]  A. Fercher,et al.  Full range complex spectral optical coherence tomography technique in eye imaging. , 2002, Optics letters.

[5]  A. Seifert,et al.  Wave-optical design of a combined refractive-diffractive varifocal lens. , 2014, Optics express.

[6]  A. Fercher,et al.  Measurement of intraocular distances by backscattering spectral interferometry , 1995 .

[7]  Sylwester Bargiel,et al.  Multi-wafer bonding technology for the integration of a micromachined Mirau interferometer , 2015, Photonics West - Optoelectronic Materials and Devices.

[8]  Angelika Unterhuber,et al.  Full-field time-encoded frequency-domain optical coherence tomography. , 2006, Optics express.

[9]  W. Drexler,et al.  Line-field parallel swept source MHz OCT for structural and functional retinal imaging. , 2015, Biomedical optics express.

[10]  D. Malacara,et al.  Interferogram Analysis for Optical Testing , 2018 .

[11]  Sylwester Bargiel,et al.  Monolithic integration of a glass membrane on silicon micro-actuator for micro-interferometry , 2014, 2014 International Conference on Optical MEMS and Nanophotonics.

[12]  A. Boccara,et al.  High-resolution full-field optical coherence tomography with a Linnik microscope. , 2002, Applied optics.

[13]  D S Mamedov,et al.  LASERS AND AMPLIFIERS: Tunable semiconductor laser with an acousto-optic filter in an external fibre cavity , 2006 .

[14]  N. Passilly,et al.  Arrays of millimeter-sized glass lenses for miniature inspection systems , 2014, Photonics Europe.

[15]  Daniel Malacara,et al.  Interferogram Analysis For Optical Testing, Second Edition , 2005 .

[16]  A. Fercher,et al.  In vivo human retinal imaging by Fourier domain optical coherence tomography. , 2002, Journal of biomedical optics.

[17]  Wolfgang Osten,et al.  itom: an open source metrology, automation, and data evaluation software. , 2014, Applied optics.

[18]  Thilo Gambichler,et al.  Applications of optical coherence tomography in dermatology. , 2005, Journal of dermatological science.

[19]  W. Osten,et al.  Optical design of a vertically integrated array-type Mirau-based OCT system , 2014, Photonics Europe.

[20]  Hrebesh M. Subhash,et al.  Full-Field and Single-Shot Full-Field Optical Coherence Tomography: A Novel Technique for Biomedical Imaging Applications , 2012 .

[21]  Peter Koch,et al.  Off-axis full-field swept-source optical coherence tomography using holographic refocusing , 2013, Photonics West - Biomedical Optics.

[22]  Changhuei Yang,et al.  Sensitivity advantage of swept source and Fourier domain optical coherence tomography. , 2003, Optics express.

[23]  J. Fujimoto,et al.  Optical coherence tomography using a frequency-tunable optical source. , 1997, Optics letters.