The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX.
暂无分享,去创建一个
S. Thibodeau | J. Cunningham | C. Moser | D. Nagorney | L. Roberts | L. Burgart | I. Aderca | Teresa A. Mettler | J. Lai | Manivannan Veerasamy | D. P. Montoya | A. Shire | S. Cazanave | A. Bani-Hani | Ruben Bonilla-Guerrero | Kadra H. Ahmed | Ileana Aderca
[1] Tara L. Kieffer,et al. Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis , 2009 .
[2] C. M. Aldaz,et al. Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias. , 2008, Oral oncology.
[3] P. Edwards,et al. Homozygous deletions may be markers of nearby heterozygous mutations: The complex deletion at FRA16D in the HCT116 colon cancer cell line removes exons of WWOX , 2008, Genes, chromosomes & cancer.
[4] S. Thorgeirsson,et al. Sulfatase 2 up‐regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma , 2008, Hepatology.
[5] O. Bruland,et al. Microarray analysis reveals down-regulation of the tumour suppressor gene WWOX and up-regulation of the oncogene TYMS in intracranial sporadic meningiomas , 2008, Journal of Neuro-Oncology.
[6] Thomas D. Schmittgen,et al. Association of MicroRNA Expression in Hepatocellular Carcinomas with Hepatitis Infection, Cirrhosis, and Patient Survival , 2008, Clinical Cancer Research.
[7] Xu Yongjian,et al. Deletion and mutation of WWOX exons 6–8 in human non-small cell lung cancer , 2008, Journal of Huazhong University of Science and Technology [Medical Sciences].
[8] R. Gomez,et al. Association between decreased WWOX protein expression and thyroid cancer development. , 2007, Thyroid : official journal of the American Thyroid Association.
[9] J. Llovet,et al. Sorafenib Improves Survival in Hepatocellular Carcinoma: Results of a Phase 3 Randomized, Placebo-Controlled Trial , 2007 .
[10] G. Stein,et al. Targeted deletion of Wwox reveals a tumor suppressor function , 2007, Proceedings of the National Academy of Sciences.
[11] C. Croce,et al. WWOX Expression in Different Histologic Types and Subtypes of Non–Small Cell Lung Cancer , 2007, Clinical Cancer Research.
[12] D. Iliopoulos,et al. Inhibition of Breast Cancer Cell Growth In vitro and In vivo: Effect of Restoration of Wwox Expression , 2007, Clinical Cancer Research.
[13] Thiru V. Lakshman,et al. Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity , 2007, International journal of cancer.
[14] R. Flavell,et al. Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure , 2006, Gut.
[15] J. Ludes-Meyers,et al. WWOX protein expression in normal human tissues , 2006, Journal of Molecular Histology.
[16] N. Kaplowitz,et al. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. , 2006, Gastroenterology.
[17] D. Iliopoulos,et al. A role for the WWOX gene in prostate cancer. , 2006, Cancer research.
[18] D. A. Gomes,et al. Characterization of the tumor suppressor gene WWOX in primary human oral squamous cell carcinomas , 2006, International journal of cancer.
[19] R. Richards,et al. Common chromosomal fragile sites and cancer: focus on FRA16D. , 2006, Cancer letters.
[20] R. Richards,et al. FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila , 2006, Oncogene.
[21] L. Hsu,et al. Light-induced retinal damage involves tyrosine 33 phosphorylation, mitochondrial and nuclear translocation of WW domain-containing oxidoreductase in vivo , 2005, Neuroscience.
[22] Q. Hong,et al. WOX1 Is Essential for Tumor Necrosis Factor-, UV Light-, Staurosporine-, and p53-mediated Cell Death, and Its Tyrosine 33-phosphorylated Form Binds and Stabilizes Serine 46-phosphorylated p53* , 2005, Journal of Biological Chemistry.
[23] T. Kuroki,et al. Common Fragile Genes and Digestive Tract Cancers , 2005, Surgery Today.
[24] James L Mohler,et al. Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. , 2005, Cancer research.
[25] M. Macleod,et al. Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR , 2005, Molecular carcinogenesis.
[26] A. Cleton-Jansen,et al. Expression analysis of candidate breast tumour suppressor genes on chromosome 16q , 2005, Breast Cancer Research.
[27] D. Amadori,et al. WWOX gene restoration prevents lung cancer growth in vitro and in vivo , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[28] L. Hsu,et al. WOX1 Is Essential for UVB Irradiation–Induced Apoptosis and Down-Regulated via Translational Blockade in UVB-Induced Cutaneous Squamous Cell Carcinoma In vivo , 2005, Clinical Cancer Research.
[29] D. Iliopoulos,et al. Concordant loss of fragile gene expression early in breast cancer development , 2005, Pathology international.
[30] G. Mills,et al. WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome , 2005, BMC Cancer.
[31] A. Paige,et al. WWOX mRNA expression profile in epithelial ovarian cancer supports the role of WWOX variant 1 as a tumour suppressor, although the role of variant 4 remains unclear. , 2005, International journal of oncology.
[32] K. Mimori,et al. Components of DNA Damage Checkpoint Pathway Regulate UV Exposure–Dependent Alterations of Gene Expression of FHIT and WWOX at Chromosome Fragile Sites , 2005, Molecular Cancer Research.
[33] J. Ferlay,et al. Global Cancer Statistics, 2002 , 2005, CA: a cancer journal for clinicians.
[34] Dimitrios Iliopoulos,et al. Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer , 2005, Oncogene.
[35] L. Hsu,et al. 17β-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo , 2005, Oncogene.
[36] J. Ludes-Meyers,et al. Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma , 2004, British Journal of Cancer.
[37] Fang Wang,et al. Parkin gene alterations in hepatocellular carcinoma , 2004, Genes, chromosomes & cancer.
[38] R. Ashfaq,et al. FHIT mRNA and protein expression in hepatocellular carcinoma , 2004, Modern Pathology.
[39] Y. Pekarsky,et al. Loss of WWOX Expression in Gastric Carcinoma , 2004, Clinical Cancer Research.
[40] A. Chinnaiyan,et al. Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23–qter and identifies underlying candidate tumor suppressor genes in prostate cancer , 2004, Oncogene.
[41] D. Iliopoulos,et al. The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma , 2004, Cancer.
[42] C. Croce,et al. The Tumor Suppressor Gene WWOX at FRA16D Is Involved in Pancreatic Carcinogenesis , 2004, Clinical Cancer Research.
[43] M. Fiorentino,et al. Predictive Value of Biological Markers for Hepatocellular Carcinoma Patients Treated with Orthotopic Liver Transplantation , 2004, Clinical Cancer Research.
[44] David I. Smith,et al. hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling. , 2004, Gastroenterology.
[45] H. Aburatani,et al. An opposing view on WWOX protein function as a tumor suppressor. , 2003, Cancer research.
[46] C. Croce,et al. Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. , 2003, Molecular cancer research : MCR.
[47] J. Ludes-Meyers,et al. WWOX, the common chromosomal fragile site, FRA16D, cancer gene , 2003, Cytogenetic and Genome Research.
[48] David I. Smith,et al. Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer , 2003, Genes, chromosomes & cancer.
[49] David I. Smith,et al. Loss of HSulf-1 Up-regulates Heparin-binding Growth Factor Signaling in Cancer* , 2003, Journal of Biological Chemistry.
[50] M. Czaja. The future of GI and liver research: editorial perspectives. III. JNK/AP-1 regulation of hepatocyte death. , 2003, American journal of physiology. Gastrointestinal and liver physiology.
[51] R. Schwabe,et al. c‐Jun‐N‐terminal kinase drives cyclin D1 expression and proliferation during liver regeneration , 2003, Hepatology.
[52] N. Chang,et al. JNK1 Physically Interacts with WW Domain-containing Oxidoreductase (WOX1) and Inhibits WOX1-mediated Apoptosis* , 2003, The Journal of Biological Chemistry.
[53] C. Croce,et al. WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer. , 2003, Cancer research.
[54] B. Song,et al. Critical role of c-Jun N-terminal protein kinase activation in troglitazone-induced apoptosis of human HepG2 hepatoma cells. , 2003, Molecular pharmacology.
[55] E. Calhoun,et al. The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1 , 2002, Genes, chromosomes & cancer.
[56] Tomoyuki Masuda,et al. M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan , 2002, Hepatology.
[57] C. Croce,et al. Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma. , 2002, Cancer research.
[58] H. Prydz,et al. Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors , 2002, Oncogene.
[59] N. Nishida,et al. Prognostic Impact of Multiple Allelic Losses on Metastatic Recurrence in Hepatocellular Carcinoma after Curative Resection , 2002, Oncology.
[60] N. Chang. A potential role of p53 and WOX1 in mitochondrial apoptosis (review). , 2002, International journal of molecular medicine.
[61] David W. Anderson,et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[62] A. Brenner,et al. WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. , 2001, Cancer research.
[63] D J Porteous,et al. WWOX: A candidate tumor suppressor gene involved in multiple tumor types , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[64] J. Zucman‐Rossi,et al. Identification of homozygous deletions at chromosome 16q23 in Aflatoxin B1 exposed hepatocellular carcinoma , 2001, Oncogene.
[65] C. Croce,et al. The tumor spectrum in FHIT-deficient mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[66] H. Kawasaki,et al. Loss of heterozygosity of the mannose 6-phosphate/insulin-like growth factor II receptor and p53 genes in human hepatocellular carcinoma. , 2001, Hepatology research : the official journal of the Japan Society of Hepatology.
[67] C J Kemp,et al. p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. , 2001, Experimental cell research.
[68] K. Buetow,et al. Human hepatocellular carcinoma is characterized by a highly consistent pattern of genomic imbalances, including frequent loss of 16q23.1–24.1 , 2001, Genes, chromosomes & cancer.
[69] J. Heath,et al. Hyaluronidase Induction of a WW Domain-containing Oxidoreductase That Enhances Tumor Necrosis Factor Cytotoxicity* , 2001, The Journal of Biological Chemistry.
[70] L. Roberts,et al. The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations. , 2000, Genomics.
[71] R. Richards,et al. Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells. , 2000, Human molecular genetics.
[72] A. Bednarek,et al. WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. , 2000, Cancer research.
[73] J. Sgouros,et al. A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D. , 2000, Cancer research.
[74] S. Thorgeirsson,et al. Alterations of the FHIT gene in human hepatocellular carcinoma. , 2000, Cancer research.
[75] S. Finkelstein,et al. Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[76] N. Nishida,et al. Accumulation of allelic loss on arms of chromosomes 13q, 16q and 17p in the advanced stages of human hepatocellular carcinoma , 1992, International journal of cancer.
[77] Michiie Sakamoto,et al. Characterization of High‐Molecular‐Mass Forms of Basic Fibroblast Growth Factor Produced by Hepatocellular Carcinoma Cells: Possible Involvement of Basic Fibroblast Growth Factor in Hepatocarcinogenesis , 1991, Japanese journal of cancer research : Gann.
[78] S. Hirohashi,et al. Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma. , 1991, Cancer letters.
[79] W. Birchmeier,et al. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells , 1991, The Journal of cell biology.