The development of eye movements in the zebrafish (Danio rerio).

We investigated the development of oculomotor activity in zebrafish embryos and larvae of ages 48-96 hrs postfertilization (hpf). The optokinetic response (OKR: smooth tracking movements evoked by a rotating striped drum) improved steadily after its onset at 73 hpf, and by 96 hpf had a achieved a gain (eye velocity/drum velocity) of 0.9, comparable to adult performance. Reset movements (the fast phase of optokinetic nystagmus) developed over 75-81 hpf. The vestibuloocular reflex (VOR: compensatory eye movements evoked by passive rotation of the head) developed over 74-81 hpf, and the associated reset movements, over 76-81 hpf. The VOR was qualitatively normal in dark-reared fish, which excludes an essential role for visual experience in its early development. Spontaneous saccadic movements (the fast shift of eye position) appeared between 81 and 96 hpf, and at 96 hpf had maximum velocities that were comparable to adults. These results are compared to, and found to be incompatible with, two earlier ideas of motor development: behavioral "differentiation" and "encephalization."

[1]  R. Baker,et al.  Characterization and adaptive modification of the goldfish vestibuloocular reflex by sinusoidal and velocity step vestibular stimulation. , 1992, Journal of neurophysiology.

[2]  T. Branchek.  The development of photoreceptors in the zebrafish, Brachydanio rerio. II. Function , 1984, The Journal of comparative neurology.

[3]  M. Bennett,et al.  Changes in gain of the vestibulo-ocular reflex induced by combined visual and vestibular stimulation in goldfish , 1986, Brain Research.

[4]  J. Lewis,et al.  Early ear development in the embryo of the Zebrafish, Danio rerio , 1996, The Journal of comparative neurology.

[5]  C A Stuermer,et al.  Retinotopic organization of the developing retinotectal projection in the zebrafish embryo , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[6]  G. L. Walls,et al.  The Vertebrate Eye and Its Adaptive Radiation , 1943 .

[7]  A. Harris.  Eye movements of the dogfish Squalus acanthias L. , 1965, The Journal of experimental biology.

[8]  H. C. Tracy,et al.  The development of motility and behavior reactions in the toadfish (Opsanus tau) , 1926 .

[9]  D. C. Higgins,et al.  Behavioral encephalization in the bullhead embryo and its neuroanatomical correlates , 1971, The Journal of comparative neurology.

[10]  K. Berridge,et al.  Causal Mechanisms of Behavioural Development: The development of action patterns , 1994 .

[11]  S. Easter,et al.  Development of the retinofugal projections in the embryonic and larval zebrafish (Brachydanio rerio) , 1994, The Journal of comparative neurology.

[12]  S. Easter,et al.  The development of vision in the zebrafish (Danio rerio). , 1996, Developmental biology.

[13]  H. E. Roaf.  The Vertebrate Eye and its Adaptive Radiation , 1943, Nature.

[14]  S. Easter,et al.  Pursuit eye movements in goldfish (Carassius auratus). , 1972, Vision research.

[15]  W. K. Metcalfe,et al.  Primary neurons that express the L2/HNK-1 carbohydrate during early development in the zebrafish. , 1990, Development.

[16]  R. Baker,et al.  Eye position and eye velocity integrators reside in separate brainstem nuclei. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[17]  J. Miller.  AUTORADIOGRAPHIC OBSERVATIONS ON THE LOCATION OF DNA-- AND RNA-- SYNTHESIZING CELLS IN RAT POPLITEAL LYMPH NODES. , 1965, The Australian journal of experimental biology and medical science.

[18]  S. Easter,et al.  Axonogenesis and morphogenesis in the embryonic zebrafish brain , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[19]  M. Westerfield,et al.  Development and axonal outgrowth of identified motoneurons in the zebrafish , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[20]  T. Branchek,et al.  The development of photoreceptors in the zebrafish, Brachydanio rerio. I. Structure , 1984, The Journal of comparative neurology.

[21]  R. Baker,et al.  Cerebellar role in adaptation of the goldfish vestibuloocular reflex. , 1994, Journal of neurophysiology.

[22]  Stephen W. Wilson,et al.  The development of a simple scaffold of axon tracts in the brain of the embryonic zebrafish, Brachydanio rerio. , 1990, Development.

[23]  D. Robinson.  The mechanics of human saccadic eye movement , 1964, The Journal of physiology.

[24]  M. Westerfield,et al.  A neural degeneration mutation that spares primary neurons in the zebrafish. , 1988, Developmental biology.

[25]  C. Kimmel,et al.  The development and behavioral characteristics of the startle response in the zebra fish. , 1974, Developmental psychobiology.

[26]  M Ito,et al.  Neurophysiological aspects of the cerebellar motor control system. , 1970, International journal of neurology.

[27]  D. Robinson.  Eye Movement Control in Primates , 1968 .

[28]  M. Bennett,et al.  Changes in gain of the vestibulo-ocular reflex induced by sinusoidal visual stimulation in goldfish , 1986, Brain Research.