An Investigation on Colon Drug Delivery System for Satranidazole Tablet

The colon targeted matrix tablet of satranidazole which is composed of polysaccharides which are susceptible to enzymatic degradation i.e. Guar gum, Xanthan gum, Guar : Xanthan gum in combination at 2 ratios (1:1) and (2:1) and Pectin coated with enteric polymer Eudragit L, Eudragit S and Eudragit RS. The SF7 formulation was found to be able, to release up to 92% of drug into colon. PVP K 30 was used as binder to fabricate a tablet having desired release characteristics. MCC was used as diluent in formulation. Coating materials used were Eudragit L, Eudragit S and Eudragit RS. As the requirement of formulation to bypass the release in stomach and small intestine Eudragit L, Eudragit S and Eudragit RS was suitable polymer in combination. Tablets coated with Eudragit L, Eudragit S and Eudragit RS in ratio of 4:16:5 with less quantity of plasticizer PEG 400 showed excellent film properties and were able to release most of the drug into colon. 10% of coating was found to be optimum. Formulation SF7 was considered as optimum batch as it delivered 96 % of drug into colon. The formulation SF7 can be employed as a promising colon specific drug delivery system of satranidazole.