Lactate quantitation in a gerbil brain stroke model by GSLIM of multiple‐quantum‐filtered signals

Quantitative magnetic resonance imaging of lactate using a zero‐quantum/double‐quantum filter and generalized spectral localization by imaging (GSLIM) was applied to a model of unilateral stroke in gerbil brain. GSLIM lactate images at 4T clearly reveal elevated concentrations of lactate in the ischemic compared with the normal hemisphere 100–175 minutes after unilateral carotid ligation. These results indicate that the technique is capable of studies of brain infarcts, and that application to human ischemic pathology in brain and other tissues may be possible.J. Magn. Reson. Imaging 1999;9:539–543. © 1999 Wiley‐Liss, Inc.

[1]  A Haase,et al.  Localized spectroscopy from anatomically matched compartments: improved sensitivity and localization for cardiac 31P MRS in humans. , 1998, Journal of magnetic resonance.

[2]  W Dreher,et al.  Temporal and regional changes during focal ischemia in rat brain studied by proton spectroscopic imaging and quantitative diffusion NMR imaging , 1998, Magnetic resonance in medicine.

[3]  Diffusion measurement in phantoms and tissues using SLIM localization. , 1997, Journal of magnetic resonance.

[4]  P. Lauterbur,et al.  Quantitative lactate‐specific MR imaging and 1H spectroscopy of skeletal muscle at macroscopic and microscopic resolutions using a zero‐quantum/double‐quantum coherence filter and SLIM/GSLIM localization , 1997, Magnetic resonance in medicine.

[5]  Zhi-Pei Liang,et al.  Biochemical heterogeneity in hysterectomized uterus measured by 31P NMR using SLIM localization , 1997, Magnetic resonance in medicine.

[6]  P. V. van Zijl,et al.  Proton MR spectroscopy in acute middle cerebral artery stroke. , 1996, AJNR. American journal of neuroradiology.

[7]  A fast method for in vivo lactate imaging , 1995, NMR in biomedicine.

[8]  Bruno Alfano,et al.  1H MR Spectroscopy in Patients with Metastatic Brain Tumors: A Multicenter Study , 1995, Magnetic resonance in medicine.

[9]  S. Rose,et al.  Image directed proton spectroscopy of gerbil brain at 7 Tesla , 1995, NMR in biomedicine.

[10]  A. Blamire,et al.  Clinical correlates of proton magnetic resonance spectroscopy findings after acute cerebral infarction. , 1995, Stroke.

[11]  J R Griffiths,et al.  Tumor metabolism: the lessons of magnetic resonance spectroscopy. , 1995, Advances in enzyme regulation.

[12]  D G Norris,et al.  Incidence of apparent restricted diffusion in three different models of cerebral infarction. , 1994, Magnetic resonance imaging.

[13]  N. C. Yue.  Advances in brain tumor imaging , 1993, Current opinion in neurology.

[14]  Zhi-Pei Liang,et al.  A theoretical analysis of the SLIM technique , 1993 .

[15]  R G Shulman,et al.  Nuclear magnetic resonance imaging and spectroscopy of human brain function. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Z P Liang,et al.  A generalized series approach to MR spectroscopic imaging. , 1991, IEEE transactions on medical imaging.

[17]  R. Ladebeck,et al.  Quantitative in vivo1H-spectroscopy of healthy and tumorous human brain tissue at 4 tesla , 1990 .

[18]  A. Wilman,et al.  Lactate editing by means of selective-pulse filtering of both zero-and double-quantum coherence signals , 1990 .

[19]  Jullie W Pan,et al.  A fully localized 1H homonuclear editing sequence to observe lactate in human skeletal muscle after exercise , 1989 .

[20]  P C Lauterbur,et al.  SLIM: Spectral localization by imaging , 1988, Magnetic resonance in medicine.

[21]  G. Radda,et al.  A 31P Nuclear Magnetic Resonance in vivo Study of Cerebral Ischaemia in the Gerbil , 1982, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  J. Passonneau,et al.  POST‐ISCHEMIC CHANGES IN CERTAIN METABOLITES FOLLOWING PROLONGED ISCHEMIA IN THE GERBIL CEREBRAL CORTEX , 1976 .